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New nerve block could ease pain after knee replacement

NCT ID NCT06920186

Symptom relief Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a new nerve block (quadri-block) helps people recover better after total knee replacement compared to the usual method (adductor canal block plus surgical infiltration). One hundred adults with knee arthritis scheduled for knee replacement will be randomly assigned to one of the two pain-block approaches. The main goal is to see which group reports better recovery 24 hours after surgery, measured by a questionnaire that covers pain, comfort, independence, and emotional state.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nerve block procedure (quadri-block or adductor canal block plus surgical infiltration)
What this could lead to
If it works, this could point toward a better way to manage pain after knee replacement, helping patients recover faster and more comfortably.
What could go wrong
This is a small, early-stage trial with only 100 participants, so results may not apply to everyone. The new block may not be better than the current standard, and any nerve block carries risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult male or female * Patient with signed consent to participate in the study, * Patient with uni or bilateral primary gonarthrosis * Indication for total knee arthroplasty. Exclusion Criteria: * History of knee fracture, arthroplasty or osteotomy * Known or unknown contraindication to ALR or locoregional anesthesia products * Neurological disease, stroke sequelae * Mental deficiency or any other reason that may hinder understanding or strict application of the protocol * Patient not affiliated to the French social security system * Patient under court protection, guardianship or curatorship * Pregnant or potentially pregnant women (women of childbearing age without effective contraception) * Patient already included in another therapeutic study protocol

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gonarthrosis Total knee arthroplasty

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clinique des Côtes du Rhône

    NOT_YET_RECRUITING

    Roussillon, 38150, France

  • Hôpital Privé Claude Galien

    RECRUITING

    Quincy-sous-Sénart, 91480, France

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