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Knee surgery recovery: could a common steroid ease pain and get you moving faster?

NCT ID NCT07442812

Symptom relief Sponsor: Haseki Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 2 times

Summary

This study follows 270 adults having knee replacement surgery to see if the steroid dexamethasone (given as a pill or through a vein) helps with early recovery. Researchers will measure pain, mobility, nausea, and need for extra painkillers. The study does not assign treatments—patients follow their own surgeon's usual practice.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone
What this could lead to
If this study shows benefit, it could support using dexamethasone to improve early recovery after knee replacement, reducing pain and nausea.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by patient choice of surgeon. The findings may not prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 270 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients aged 50 to 80 years with a diagnosis of primary knee osteoarthritis who are scheduled to undergo elective primary total knee arthroplasty at Istanbul Sultangazi Haseki Training and Research Hospital. Eligible participants have an ASA physical status of I or II and are able to ambulate independently prior to surgery. All participants are capable of understanding the study procedures and providing written informed consent. Patients are managed according to the routine perioperative dexamethasone protocols of the surgeon selected by the patient. Group allocation is based on the standard clinical practice of the chosen surgeon and not assigned by the investigators. Participants are followed prospectively to evaluate postoperative pain, inflammatory response, functional mobility, postoperative nausea and vomiting, and analgesic requirements during the early postoperative period.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 50 and 80 years * Diagnosis of primary knee osteoarthritis (primary gonarthrosis) * Scheduled for elective primary total knee arthroplasty * ASA physical status I or II * Ability to ambulate independently (with or without assistive devices) preoperatively * Ability to understand study procedures and complete pain and functional assessments * Provision of written informed consent Exclusion Criteria: * Revision total knee arthroplasty * History of knee joint infection * Inflammatory arthritis (e.g., rheumatoid arthritis) * Chronic systemic corticosteroid use * Uncontrolled diabetes mellitus * Known endocrine disorders affecting glucose metabolism * Active infection at any site * Known hypersensitivity to corticosteroids * Severe hepatic, renal, or cardiac disease * Neurological or musculoskeletal disorders affecting gait or balance * Inability or unwillingness to comply with study procedures

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gonarthrosis; primary Knee osteoarthritis Total knee arthroplasty

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sultangazi Haseki Training and Research Hospital

    RECRUITING

    Istanbul, Istanbul, 34200, Turkey (Türkiye)

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