KNEE OSTEOARTHRITIS

This pilot study is testing a new surgical instrument designed to improve ligament balancing during total knee replacement surgery. The goal is to see if this tool can make the process of adjusting knee ligaments more consistent and predictable for surgeons. The study will involv…

This study is testing a specialized knee replacement system designed for patients whose first knee replacement has failed or who have severe knee damage. Researchers will follow about 380 patients for up to 10 years to see if the new implant improves knee function, reduces pain, …

This study compares two different cell injection treatments for knee osteoarthritis. Researchers want to see whether cells taken from a patient's bone marrow or cells taken from their fat tissue work better at reducing pain and possibly slowing the arthritis. About 200 people wit…

This is an early-stage study to test the safety and initial effectiveness of a new gene therapy called BBM-A101 for knee osteoarthritis. The therapy involves a single injection into the knee, designed to deliver a therapeutic gene to help control the disease. The study will enrol…

This study aims to use artificial intelligence to predict how well patients will recover after knee replacement surgery. Researchers will collect detailed information from 197 people with severe knee arthritis before their surgery, including genetic data, movement patterns, and p…

This study is comparing different types of knee realignment surgery (osteotomy) to see which works best long-term for treating arthritis in patients whose legs are bowed or knock-kneed. It aims to control the disease and delay or avoid the need for a full knee replacement. Resear…

This study is testing whether a single injection of processed human placental tissue into the knee joint can safely reduce pain and improve function for people with mild-to-moderate knee osteoarthritis. About 260 participants will be randomly assigned to receive either the experi…

This study is testing whether hyaluronic acid injections into the knee can reduce specific inflammation markers and provide pain relief for people with knee osteoarthritis. Researchers will compare results from 50 participants receiving the injection to those receiving a placebo.…

This study is testing whether a special treadmill training program before knee replacement surgery can help prevent falls during recovery. About 200 people scheduled for knee replacement will be split into two groups: one gets standard fall-prevention advice, and the other gets t…

This study is testing if adding a special low-level laser treatment to a standard home exercise program can better help people with knee osteoarthritis. It will involve 62 adults over 50 who have moderate knee arthritis. Researchers will compare pain, mobility, muscle thickness, …

This study compares two different nerve block techniques for managing pain after total knee replacement surgery. Researchers want to see which combination of nerve blocks provides better pain relief while allowing patients to move their leg muscles sooner after surgery. The study…

This study is testing a minimally invasive procedure called genicular artery embolization (GAE) to see if it can reduce knee pain and inflammation in adults with osteoarthritis. Researchers will measure changes in pain scores, knee fluid, and MRI scans before and after the proced…

This study aims to see if a newer anesthesia drug called remimazolam causes less post-surgery confusion (delirium) than the commonly used drug propofol in older adults having hip or knee surgery. Researchers will compare how often delirium occurs in the first three days after sur…

This study is testing a non-drug method to see if it can help people with knee arthritis and chronic low back pain move better and feel better. Researchers will temporarily restrict blood flow to a participant's thigh for short periods over two weeks. The goal is to see if this i…

This small, early-stage study is testing whether a non-invasive brain stimulation technique called rTMS can boost the benefits of Tai Chi for people with knee osteoarthritis and depression. Researchers want to see if stimulating two different brain areas is safe, feasible, and mo…

This study is testing if a minimally invasive procedure can relieve knee pain caused by osteoarthritis. The procedure, called genicular artery embolization (GAE), uses tiny particles to block abnormal blood flow thought to cause inflammation and pain. Researchers will compare pai…

This study is testing whether adding a protein called fibrinogen to a standard knee injection (hyaluronic acid) can better relieve pain and improve movement in people with knee osteoarthritis. All 31 participants will receive the combined injection, and researchers will track the…

This study compares two common injection treatments for painful knee arthritis. Researchers want to see if platelet-rich plasma (PRP) injections work better than hyaluronic acid (HA) gel injections at reducing pain and improving knee function. The study will follow 150 adults wit…

This study is testing a non-invasive, high-intensity pulsed electromagnetic field (PEMF) device to see if it can reduce pain and improve strength and mobility in older adults with knee osteoarthritis. Researchers will compare applying the therapy just to the knee versus applying …

This study is testing whether a single injection of a collagen solution into the knee joint works better than a placebo (saltwater) injection to ease pain and improve function in people with knee osteoarthritis. It will involve 204 participants whose symptoms haven't improved wit…

This study is testing if a special exercise program before hip or knee replacement surgery helps people recover faster and feel better. Researchers will enroll 44 adults with severe osteoarthritis who are scheduled for surgery. They will measure if the pre-surgery exercises impro…

This study compares two different approaches to knee replacement surgery for people with severe knee arthritis. One method positions the new joint in a neutral position, while the other tries to match the knee's natural alignment. Researchers want to see which technique leads to …

This study is testing whether adding foot massage to standard cold therapy helps people feel better after knee replacement surgery. Researchers will compare pain levels, satisfaction, and painkiller use between patients who get both treatments and those who only get cold therapy.…

This study is testing two different additives mixed with a standard numbing medicine to see which one works better at reducing pain after knee replacement surgery. Researchers will compare how much opioid pain medication patients need in the first day after surgery when using the…

This study is testing whether a combination of two gentle physical treatments can help people with knee osteoarthritis. Researchers want to see if the Bowen technique (a light touch therapy) combined with walking backwards can improve hamstring flexibility, reduce pain, and make …

This study is testing whether a medication called duloxetine, taken before and after knee replacement surgery, can help patients use fewer opioid painkillers during recovery. Researchers will compare 150 patients with knee osteoarthritis who receive either duloxetine or a placebo…

This study is testing if a program of exercise and education before knee replacement surgery helps people recover better. It will compare 110 patients who do supervised workouts twice a week before surgery to those who receive standard care. The main goal is to see if this 'preha…

This study is testing whether a 20-day thermal spa treatment in Enghien-les-Bains, France, can meaningfully reduce pain and improve daily function for people with knee osteoarthritis. It will enroll 76 participants aged 50-80 and compare their results at 6 months to a group of si…

This study is testing if a new, more concentrated version of a patient's own blood platelets (called SRF) works better than the standard version (PRP) for treating knee osteoarthritis. About 90 adults with knee pain and stiffness will receive a series of injections and be followe…

This study is testing whether adding shock wave therapy to standard knee strengthening exercises helps reduce pain and improve movement better than exercises alone in people with knee osteoarthritis. It will involve 40 patients who are already in the hospital for recovery. Partic…

This study is comparing two different approaches for a nerve block (proximal and distal adductor canal block) to see which one better controls pain and improves mobility after total knee replacement surgery. The research involves 78 adults with knee osteoarthritis who are having …

This study is testing whether using video games during physical therapy exercises helps people with knee arthritis more than standard exercises. 60 participants with knee osteoarthritis will do 10 weeks of leg-strengthening exercises, with one group using special sensors and game…

This study aims to find the best way to manage pain after knee replacement surgery. Researchers are comparing two different nerve block techniques (iPACK and BiFeS) when used with a standard pain control method. The goal is to see which combination provides better pain relief, im…

This study is testing if a mobile phone app can help older adults recover better after hip, knee, or spine surgery. The app reminds patients to do safe, in-bed exercises and adjusts the difficulty based on how they feel. Researchers will see if using the app helps patients do bet…

This study is testing whether a specific hands-on physical therapy technique can reduce pain and inflammation in people with knee osteoarthritis. Researchers will compare the real therapy to a fake version that looks similar but lacks the specific movements. Forty adults with mod…

This study compares two common anesthesia methods—spinal (numbing from waist down) versus general (fully asleep)—for patients getting hip or knee replacements. Researchers want to see which approach leads to better recovery, including less pain and nausea, shorter hospital stays,…

This study aims to find out which treatment works better for people with knee osteoarthritis: a targeted injection that blocks pain signals (genicular nerve block) or a standard course of physical therapy. Researchers will measure changes in pain, knee function, walking ability, …

This study is testing if adding a simple sugar solution (dextrose) to a standard numbing injection can better relieve chronic pain from knee osteoarthritis. Researchers will compare the sugar-water mix against the numbing medicine alone in 60 adults with persistent knee pain. The…

This study is testing a new knee brace (ROAM OA) against a commonly used one to see which is better at reducing pain and improving walking for people with knee osteoarthritis. Researchers will measure changes in pain, walking ability, and knee stress over 8 weeks. The goal is to …

This study is testing whether an 8-week yoga program can help people with knee osteoarthritis feel better and move more easily. Researchers will compare yoga to a standard therapeutic exercise program in 90 participants. The goal is to see if yoga improves pain, balance, and dail…

This study is comparing two different ways to guide a procedure that uses heat to quiet nerves causing knee osteoarthritis pain. Researchers want to see if using ultrasound imaging is more effective than the standard X-ray (fluoroscopy) method. They will measure changes in pain a…

This study is testing whether a collagen-based injection called CartiPRO can safely provide long-term relief from knee pain caused by osteoarthritis. About 194 adults with knee pain will receive either CartiPRO or a standard injection, with a second dose given six months later. R…

This study is testing whether a single injection into the knee joint can safely reduce pain and improve movement in people with osteoarthritis and inflammation. Researchers will compare the experimental injection called 4P004 against a placebo injection in 129 adults aged 40-80. …

This study is creating a large registry to track and compare different pain management approaches for people with knee osteoarthritis. It will follow 10,000 patients receiving treatments like injections, nerve blocks, medications, or knee replacement surgery. The goal is to colle…

This study aims to understand how remote monitoring devices and neighborhood resources affect recovery after knee replacement surgery. Researchers will track 150 patients using smart knee implants that measure movement and compare their recovery to patients receiving standard car…

This study aims to understand the connection between how the knee is aligned on an X-ray and a patient's experience of pain, daily function, and fear of movement (kinesiophobia). Researchers will observe 100 adults with knee osteoarthritis, using their recent X-rays and questionn…

This study follows golfers who get hip, knee, or shoulder replacement surgery to see how and when they return to playing golf. Researchers will track 432 patients for one year after surgery, checking their progress at 6 weeks, 3 months, 6 months, and 12 months. The goal is to bet…

This study aims to discover biological markers in blood and joint fluid that can predict how knee osteoarthritis will progress and which patients might eventually need joint replacement. Researchers will follow 300 patients with knee arthritis for up to 10 years, collecting sampl…

This study aims to create and test an Italian version of a knee assessment questionnaire. Researchers will translate the questionnaire and then have 200 Italian patients with knee osteoarthritis complete it. The goal is to provide doctors with a reliable tool to measure knee symp…

This study follows 50 patients for over 5 years after knee realignment surgery to understand how the procedure affects the kneecap joint over time. Researchers are observing patients who previously had surgery to correct knee deformity and early arthritis, tracking changes throug…

This study aims to understand what makes a doctor's visit effective for knee arthritis pain. Researchers will observe 220 adults with knee osteoarthritis as they use a standard pain-relief gel for 8 weeks. They will measure things like patient-clinician rapport, body language, an…

This study aims to improve knee replacement surgery for people with severe arthritis and a bow-legged alignment. Researchers will use special standing and lying-down CT scans to compare a patient's bad knee to their good one. The goal is to create better guidelines for surgeons o…

This study aims to see if data from smart shoe insoles and other pre-surgery information can predict how well patients will recover after a total knee replacement. Researchers will observe 200 patients, analyzing their walking patterns before surgery and their reported pain and m…