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Sugar water shots guided by MRI may ease knee pain better

NCT ID NCT06755697

Symptom relief Sponsor: Shin Kong Wu Ho-Su Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether injecting dextrose (a sugar solution) into specific spots seen on MRI works better than injecting it into the knee joint for osteoarthritis. Sixty adults aged 45-80 with moderate knee OA will receive either MRI-guided extra-articular or ultrasound-guided intra-articular injections, plus physical therapy. The goal is to see which approach improves pain, stiffness, and function more over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dextrose (sugar water) injection
What this could lead to
If it works, this could offer a cheaper, more effective injection method for knee osteoarthritis pain and function.
What could go wrong
This is a small, early-stage trial with only 60 people. The benefit over standard injections may be small or none, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. . age between 45 to 80 years old; 2. . meet at least three of the six American College of Rheumatology (ACR) criteria, including age over 50 years, morning stiffness less than 30 minutes, crepitus in passive knee movements, bony tenderness, bony enlargement, and no palpable warmth; 3. . radiologic grading of 2 or 3 according to Kellgren-Lawrence criteria; 4. showing willingness to receive prolotherapy. Exclusion Criteria: 1. . severe systemic disorders including cancer, uncontrolled diabetes mellitus, sepsis, or cardiopulmonary diseases; 2. . history of anticoagulation therapy, knee injection over the past three months; 3. . history of knee surgery or candidates for knee arthroplasty; 4. . history of drug abuse; 5. . a history of intolerance to prolotherapy; 6. . pregnancy; 7. . infectious arthritis, inflammatory joint diseases, joint dysplasia; 8. Body Mass Index (BMI) greater than 35 kg/m2; 9. . not suitable or no willing to received MRI examination of the knee.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glucose Knee osteoarthritis MRI Physical therapy Prolotherapy Rehabilitation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shin Kong Wu Ho-Su Memorial Hospital

    RECRUITING

    Taipei, Taiwan

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