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Knee pain relief without surgery? PRP injections tested against standard care

NCT ID NCT07016672

Symptom relief Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study tests whether injections of platelet-rich plasma (PRP) work better than hyaluronic acid (HA) for people with advanced knee osteoarthritis (grades III or IV). 150 participants will receive three injections of either PRP or HA and be followed for a year. The goal is to see which treatment reduces pain and improves knee function more.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) and hyaluronic acid (HA)
What this could lead to
If PRP works better than HA, it could offer a longer-lasting, non-surgical option for people with advanced knee osteoarthritis who cannot have surgery.
What could go wrong
This is a small, early-stage study with no blinding, so results may be biased. PRP is not yet proven for advanced osteoarthritis, and benefits may be modest or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years ; 2. MRI confirmed grade III or IV unilateral gonarthrosis ; 3. Pain ≥ 3/10 on the visual analogue scale (VAS); 4. Patient with a BMI \< 35 5. Patient capable of giving consent prior to participation in the study; 6. Affiliated or entitled under a social security scheme. Exclusion Criteria: 1. Non-steroidal anti-inflammatory drugs\* or corticosteroids\*\* taken in the 7 days prior to inclusion; 2. Local injection of hyaluronic acid in the 2 months prior to inclusion; 3. Local injection of PRP within 1 year prior to inclusion; 4. Local injection of corticosteroids within 5 months prior to inclusion; 5. Current anticoagulant treatment that cannot be stopped during the hyaluronic acid or PRP injection protocol period; 6. Patient diagnosed with any type of cancer in the last 3 years; 7. Pregnant women, women in labour or breast-feeding women; 8. Patients under judicial protection (guardianship, curatorship, etc.) or safeguard of justice; 9. Any other reason which, in the opinion of the investigator, could interfere with the evaluation of the study objectives. * Acetylsalicylic acid is allowed when it is prescribed as an antiplatelet agent at doses lower than or equal to 160 mg per day. It has, indeed, no anti-inflammatory effect at these doses. * Corticosteroids can be administered when they have a local action different from the one applied to the treated knee (cutaneous, instiled or inhaled routes).

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre Hospitalier Intercommunal de Toulon- La Seyne sur Mer - Hôpital Sainte Musse

    RECRUITING

    Toulon, Var, 83100, France

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