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New scan technique could pinpoint exactly where knee pain starts

NCT ID NCT07625150

Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to develop a better way to locate painful inflammation in the knee joint for people with patellofemoral osteoarthritis. Researchers will use a special PET/MRI scan to see how inflammation changes when the knee is under pressure. About 50 adults, including both patients with knee pain and healthy volunteers, will take part. The goal is to improve understanding of what causes pain, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population includes outpatient individuals with patellofemoral joint osteoarthritis (PFJ OA) and healthy asymptomatic volunteers recruited from the University of California, San Francisco (UCSF) and the surrounding community

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult with the capacity to give informed consent * Ability to perform 25 single-leg squats * No traumatic knee injuries/surgeries since last visit for the parent study (IRB #21-34763) * No investigational drugs since last visit for the parent study (IRB #21-34763) * No contraindications to MRI or PET tracer since last visit for the parent study (IRB #21-34763) * Not taking steroid injections * Not pregnant * Additional inclusion criteria for healthy volunteers: Minimal pain (VAS=0-1) during a series of 25 single-leg squats on one or both legs Exclusion Criteria: * Inability to consent for themselves * Inability to perform 25 single-leg squats with the study leg * New traumatic knee injuries/surgeries since last visit for the parent study (IRB #21-34763) * Taking investigational drugs since last visit for the parent study (IRB #21-34763) * New contraindications to MRI or PET tracer since last visit for the parent study (IRB #21-34763) * Taking steroid injections * Pregnant * Diabetic * Additional exclusion criteria for healthy volunteers: VAS of 2 or greater during a series of 25 single-leg squats on both legs

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Conditions

The condition(s) this trial relates to.

inflammatory disease osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inflamation Knee osteoarthritis Knee pain Patellofemoral osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UCSF Radiology China Basin

    RECRUITING

    San Francisco, California, 94107, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.