KNEE OSTEOARTHRITIS

This study tests a single injection of stem cells (ELIXCYTE) into the knee joint to see if it reduces pain and improves function in people with knee osteoarthritis. About 165 adults aged 40 to 80 with moderate knee arthritis will receive either the stem cells or a placebo (salt w…

This study looks at how well a knee replacement device called MOTO Medial® works for people with knee osteoarthritis. About 269 adults who need partial knee replacement will be followed for several years. Researchers will measure pain, movement, and how long the implant lasts usi…

This early-stage study tests whether a single injection of a person's own stem cells into the knee is safe and might help with osteoarthritis or cartilage injuries. Sixteen adults aged 18-60 with knee pain will receive the injection and be followed for two years. The main goal is…

This study looks at how well a new knee replacement part (the tibial baseplate) stays in place over time. It involves 31 adults with knee osteoarthritis who need a total knee replacement. Researchers will use special X-rays to measure any movement of the implant at 6 months, 1 ye…

This study looks at whether combining two types of exercises—Feldenkrais and active release—can help people with knee osteoarthritis feel less pain and move better. The study includes 40 adults aged 40-60 with mild to moderate knee pain. Researchers will measure pain levels and h…

This study tests whether a new model where physiotherapists lead primary care for hip and knee pain can improve patients' daily function and quality of life. About 728 adults in Canada with hip or knee pain will take part. The goal is to see if this approach helps people feel bet…

This study tests whether a single injection of a mix of platelet-rich plasma (from your own blood) and a gel-like substance can reduce pain and stiffness in people with moderate to severe knee osteoarthritis. About 280 adults with knee arthritis grade 3 or 4 will receive either t…

This study aimed to see if a short course of steroids (methylprednisolone) after knee replacement surgery could improve pain, movement, and sleep while reducing the need for strong painkillers. It was designed for adults having their first knee replacement, but the study was with…

This study looks at whether adding a special laser treatment (CO2 infrared laser moxibustion) to a standard exercise program can reduce knee pain and improve function in people with knee osteoarthritis. About 68 adults aged 55 to 65 with knee arthritis will be randomly assigned t…

This study compares two exercise programs—core stability exercises versus ankle and foot strengthening—to see which better reduces pain and improves daily function in people with knee osteoarthritis. About 100 adults aged 40 and older with moderate knee osteoarthritis will partic…

This study tests whether a patient-navigation-based exercise program before knee replacement surgery helps people recover better. 84 adults with knee osteoarthritis scheduled for a total knee replacement will be enrolled. The program focuses on exercises done before surgery to im…

This study looks at whether starting to walk soon after a type of knee surgery (open wedge high tibial osteotomy) helps reduce pain, improve function, and get people back to normal activities faster. About 72 people with knee arthritis will be followed. The goal is to see if earl…

This study looks at whether platelet-rich plasma (PRP) injections, made from a patient's own blood, can reduce pain and improve leg function in people with knee osteoarthritis. About 110 adults over 35 with knee arthritis are taking part. The goal is to see which method of prepar…

This study tests a treatment called cryoneurolysis, which freezes nerves around the knee before total knee replacement surgery. The goal is to reduce pain and the need for strong painkillers (opioids) after surgery. About 100 adults with knee osteoarthritis will be randomly assig…

This study looks at whether adding mental exercises—like imagining movements or watching exercise videos—to standard physical therapy can help people recover better after knee replacement surgery. About 36 adults who had a knee replaced will be split into three groups: standard t…

This study tests a nerve stimulation device (DRG-S) to treat chronic knee pain from osteoarthritis in 30 adults. Participants have had pain for at least a year and either want to avoid knee replacement or are not candidates for it. The main goal is to see if at least half of pati…

This study looks at whether placing cabbage leaves on the knee can help reduce pain and improve movement and quality of life in people with knee osteoarthritis. About 90 adults with knee pain will be split into three groups: two groups will use cabbage leaves (one at room tempera…

This study tests a procedure called genicular artery embolization (GAE) against standard steroid injections for people with knee osteoarthritis. 264 adults with mild to severe knee pain that hasn't improved with other treatments will be randomly assigned to one of the two options…

This study tests if a non-invasive brain stimulation technique called tDCS can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with persistent knee pain will receive either real or sham tDCS for 15 sessions over three weeks. Researchers will …

This early-stage study tests the safety of a new treatment called Allocetra-OTS for people with severe knee osteoarthritis who are already considering surgery. 18 adults will receive an injection into the knee and be monitored for side effects and pain relief. The goal is to see …

This study looks at whether robot-assisted knee replacement surgery leads to better pain relief and recovery than traditional surgery. About 95 adults with knee osteoarthritis will have one type of surgery and track their pain and opioid use for weeks after. The goal is to see wh…

This study compares Basic Body Awareness Therapy (BBAT) — a gentle, mindful movement approach — to standard physiotherapy and home exercises for people with knee osteoarthritis. Researchers want to see if BBAT can improve pain, muscle strength, balance, and quality of life better…

This study tests whether using a virtual reality system at home can help people with knee osteoarthritis feel less pain. Fifty adults will either play VR games that mimic physiotherapy exercises or follow a standard exercise program for 12 weeks. The main goal is to see if this a…

This study looks at two types of leg exercises to see which one better reduces pain and improves daily function in women aged 35-60 who have knee osteoarthritis and front knee pain. Seventy participants will be randomly assigned to either closed kinetic chain exercises or isometr…

This study tests a robotic knee exoskeleton called Keeogo to see if it helps veterans with knee osteoarthritis walk, climb stairs, and move more easily compared to their regular knee braces. About 32 veterans with moderate to severe knee arthritis will try the device in a lab set…

This study tests whether taking a probiotic supplement for 6 months can reduce pain, improve knee function, and boost quality of life in women aged 45-70 with knee osteoarthritis. Participants are randomly assigned to receive either the probiotic or a placebo, and researchers mea…

This study compares two pain-relief methods—radiofrequency and phenol injection—for people who still have pain after knee replacement surgery. 140 adults will be randomly assigned to one of the two treatments. Researchers will measure pain levels before and up to 6 months after t…

This study tests a procedure called genicular artery embolization (GAE) for knee osteoarthritis pain. It works by injecting tiny beads into blood vessels that feed inflamed parts of the knee, reducing blood flow and inflammation. About 100 people with moderate to severe knee pain…

This study tests whether combining blood flow restriction with anti-gravity treadmill training works better than treadmill training alone for knee osteoarthritis. About 70 adults aged 45-80 with confirmed knee OA will take part. The goal is to reduce pain, stiffness, and improve …

This study was designed to see if an artificial intelligence (AI) mobile app could help people with knee osteoarthritis do their home exercises better. It planned to compare two groups: one using the AI app for real-time feedback and another using a paper booklet. The goal was to…

This study tests a treatment called biofiller PRP for people with knee osteoarthritis. It aims to see if this injection can reduce pain, improve movement, and even thicken knee cartilage. About 60 adults aged 45-65 with moderate knee arthritis will take part. The results will be …

This early-stage study tests a new gel form of ketoprofen, a common pain reliever, applied to the skin for knee osteoarthritis. About 40 adults with knee osteoarthritis will use the gel to see if it reduces pain and improves joint function. The goal is to find a convenient, topic…

This study compares two ultrasound-guided procedures for people with knee osteoarthritis who haven't gotten relief from standard treatments like medication or physical therapy. One method uses a chemical called phenol to block pain signals for a longer time, while the other uses …

This study tests a simple goal-setting tool for people with knee pain or injury who are seeing an orthopedic surgeon. The tool helps patients identify specific, measurable, and time-bound goals for their treatment. The goal is to improve shared decision-making and make sure patie…

This study tests whether using a blood pressure cuff during low-weight leg exercises (blood flow restriction) can reduce pain and improve strength and mobility in people with knee osteoarthritis. 75 adults aged 40-65 with moderate knee arthritis will do 16 supervised sessions ove…

This study looks at how well people with knee osteoarthritis can sense the position of their knee with and without looking. Researchers measured knee joint position sense in 120 adults aged 40-80 using a simple inclinometer. The goal is to understand how vision affects joint awar…

This study looks at whether using a shared decision-making tool helps patients with severe hip or knee osteoarthritis feel more satisfied with their treatment. About 615 patients will be followed for one year after surgery to measure pain, physical function, quality of life, and …

This study looks at two different non-surgical ways to treat knee osteoarthritis in 300 military members and their families. All participants will follow standard guidelines from the VA and Department of Defense. The goal is to see which approach works better for pain and movemen…

This study follows 124 golfers who had hip, knee, or shoulder replacement surgery to see how many return to golf and how long it takes. Researchers will also track changes in handicap, mobility, and joint pain over one year. The goal is to give patients and doctors realistic expe…

This study looks back at 166 knee replacement patients who received a nerve block for pain. Researchers want to see how much pain they feel once the block wears off, and whether a special education session helps reduce that pain. The goal is to better understand and manage pain a…

This study looks at whether it's better to have both knees replaced during the same surgery or to do them separately. It involves 224 people with knee osteoarthritis who are considering bilateral knee replacement. The goal is to help patients and surgeons make a more informed cho…

This study looks at how common nerve-related pain is in people with knee osteoarthritis and whether it's linked to night pain. Researchers will ask 150 participants about their pain and sleep quality. The goal is to better understand these connections, not to test a new treatment…

This study looks at whether using a wrist activity tracker, plus coaching and financial rewards, can help people become more physically active after total knee replacement surgery. About 600 adults aged 40-85 who are scheduled for knee replacement will be randomly assigned to usu…