Knee osteoarthritis

This trial aims to see if there is a difference in how well two cementless total knee replacement implants hold up over time. About 50 people with knee osteoarthritis will be randomly assigned to receive either the Triathlon Tritanium or the GMK Sphere implant. Using CT scans, re…

This study follows people with knee osteoarthritis who receive one of two total knee replacement designs: a cruciate-retaining (CR) or a posterior-stabilized (PS) implant. The goal is to compare how well each design relieves pain, restores function, and holds up over time. Resear…

This study tests whether a home exercise program using a blood pressure cuff to partially restrict blood flow can help people regain leg muscle strength and walking ability after a total knee replacement. Participants will do light exercises three times a week for ten weeks. The …

This study tests a combination of a patient's own stem cells and platelet-rich plasma to help heal broken bones that won't mend on their own and to treat knee arthritis. For people needing a knee replacement, doctors use custom 3D-printed guides made from the patient's scans to i…

This early-phase trial tests the safety of Allocetra-OTS, a cell therapy made from donor immune cells, injected into the knee joint of 18 people with end-stage osteoarthritis who are candidates for surgery. Researchers will monitor side effects and measure pain relief using a sta…

This study tests whether robot-assisted knee replacement surgery leads to better results than traditional manual surgery for people with knee osteoarthritis. About 95 participants will receive the robot-assisted procedure and use a special knee brace to track motion. Researchers …

This study tests whether stem cells taken from a person's own belly fat can help regenerate knee cartilage and reduce pain from osteoarthritis. Sixty adults with moderate to severe knee arthritis will receive either a stem cell injection or a standard hyaluronic acid shot. Resear…

This study looks at how stable a new type of knee replacement part (the tibial baseplate) is over time. It involves 31 people with knee osteoarthritis who are getting a total knee replacement. Researchers will use special X-rays to measure any movement of the implant between 6 mo…

This Phase 3 trial tests whether a single injection of ELIXCYTE, made from donor stem cells, can reduce knee pain better than a placebo (saline). About 165 adults aged 40-80 with moderate knee osteoarthritis who haven't gotten relief from standard treatments are participating. Th…

This early-stage trial tests whether injecting a patient's own stem cells into the knee can safely treat osteoarthritis and cartilage defects. Sixteen adults with knee pain will receive one injection of stem cells grown from their own bone marrow. Researchers will track side effe…

This study looks at how well a partial knee replacement device called MOTO Medial® works for people with knee osteoarthritis. About 269 adults will be followed for several years to see if their pain, knee function, and quality of life improve after surgery. The goal is to help pe…

Researchers are comparing two ways to perform total knee replacement in patients with obesity and knee arthritis. One method uses custom-made guides based on each patient's knee scans, while the other uses standard surgical tools. The trial measures how well the knee aligns, how …

This study tests whether a 10-week telehealth program that combines gentle exercise with mindfulness can help people with knee osteoarthritis feel less pain and move better. Researchers will compare the mindful exercise group to an exercise-only group. All sessions happen remotel…

Researchers are observing people with knee osteoarthritis who receive an injection of Arthrosamid, a hydrogel, into the affected knee. The study follows about 200 adults over the long term to track side effects and changes in pain, stiffness, and physical function. Because it is …

This study looks at whether a 6-month thermal spa treatment program can meaningfully reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare results from 76 participants aged 50-80 who receive the spa therapy against an external group r…

This study tests whether adding shock wave therapy to a knee strengthening exercise program reduces pain and improves function more than exercise alone in people with knee osteoarthritis. Forty patients with moderate knee pain will be randomly assigned to either exercise only or …

This study tests whether taking probiotic supplements for 6 months can reduce pain, improve knee function, and boost quality of life in women aged 45-70 with knee osteoarthritis. Researchers will compare the probiotic group to a placebo group to see if the gut bacteria help lower…

This study tests a goal-setting program for adults with knee problems like arthritis or injuries. Participants work with their surgeon to create specific, measurable goals and track progress. The aim is to see if this approach helps patients achieve their treatment goals and impr…

This study tests different types and doses of vitamin K in 55 adults aged 60 and older with knee osteoarthritis. Researchers want to see if vitamin K can improve knee health by measuring changes in blood markers. The goal is to find the best form and dose for future larger studie…

This study tests whether a digital therapeutic called MORA Cure can reduce knee pain in adults over 50 with knee osteoarthritis and anterior knee pain. Participants use a mobile app for 8 weeks that provides personalized exercises and cognitive behavioral therapy content. The app…

This study tests a single injection called 4P004 for people with knee osteoarthritis and synovitis (inflammation). About 129 adults aged 40-80 will receive either the injection or a placebo. The goal is to see if it reduces daily knee pain and improves function over 12 weeks.

This early-stage trial tests an experimental drug called RAB001, given as an injection into the knee joint, for people with knee osteoarthritis. The study includes 60 participants aged 40 to 75 who have persistent knee pain despite conservative treatments. Researchers are primari…

This study tests whether a supervised exercise program before hip or knee replacement surgery can improve recovery, function, and quality of life. 44 adults with advanced osteoarthritis will do 3 weekly physiotherapy sessions plus daily home exercises for several weeks before the…

This Phase 2 trial tests whether a paste made with ejiao (a traditional Chinese ingredient) can reduce knee pain in people with osteoarthritis. Sixty adults with knee pain will use either the ejiao paste, a similar paste without ejiao, or a synthetic control. The study aims to se…

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study compares two exercise programs—closed kinetic chain exercises and isometric exercises—to see which better reduces pain and improves function in women aged 35-60 with patellofemoral pain syndrome and knee osteoarthritis. Seventy participants will be randomly assigned to…

This study looks at whether starting to walk earlier after a type of knee surgery (open wedge high tibial osteotomy) helps reduce pain and improve function in people with knee osteoarthritis. About 72 participants will either start partial weight bearing at 2 weeks or wait until …

This study compares two types of blood flow restriction therapy (using a cuff to limit blood flow during exercise) against standard moderate strength training in 75 people with knee osteoarthritis. Participants will do supervised exercises twice a week for 8 weeks. The goal is to…

This study was designed to see if an artificial intelligence app could help people with knee osteoarthritis do their exercises correctly at home. It planned to compare the app group to a group using a paper exercise booklet. The study was withdrawn before any participants were en…

This study looks at whether a 12-week group exercise program called Les Mills Thrive can change how muscles work and improve strength, balance, and symptoms in 42 older adults with knee osteoarthritis. Participants will attend weekly classes that include flexibility, strength, an…

This study tests a procedure called genicular artery embolization (GAE) for knee osteoarthritis pain. It involves injecting microscopic spheres into a knee artery to reduce blood flow and inflammation. About 100 people with moderate to severe knee pain will be randomly assigned t…

This study looks at whether combining two types of exercises—Feldenkrais and active release—with standard physical therapy can help people with knee osteoarthritis feel less pain and move better. Forty adults aged 40 to 60 with mild to moderate knee OA will do these exercises thr…

This study tests whether adding blood flow restriction (a technique that gently limits blood flow to the legs) to walking on an anti-gravity treadmill can better reduce pain and improve function in people with knee osteoarthritis. About 70 adults aged 45-80 with knee arthritis wi…

This study tests whether adding a special laser treatment (CO2 infrared laser moxibustion) to standard exercise can reduce knee pain and improve movement in people with knee osteoarthritis. About 68 adults aged 55-65 with knee arthritis will receive either exercise alone or exerc…

This study tests whether a single injection of a mix of platelet-rich plasma (from your own blood) and hyaluronic acid can safely reduce pain and improve function in people with moderate to severe knee osteoarthritis. About 280 adults with grade 3-4 knee arthritis will receive ei…

This study compares a mind-body approach called Basic Body Awareness Therapy (BBAT) to standard physiotherapy and home exercise for people with knee osteoarthritis. BBAT focuses on gentle, mindful movements to improve posture, balance, and pain management. Researchers will measur…

This study planned to test whether a 6-day course of oral methylprednisolone after total knee replacement could improve pain, sleep, and knee movement. Participants would also receive a steroid injection during surgery. The study was withdrawn before enrolling anyone, so no concl…

This study tests whether applying cabbage leaves to the knee can reduce pain, improve physical function, and boost quality of life in people with knee osteoarthritis. Researchers will compare two different cabbage leaf preparations against standard care in 90 adults over four wee…

This study looks at two different methods to reduce pain in people who have had knee replacement surgery due to arthritis. One method uses radiofrequency (heat) to calm the nerve, and the other uses a chemical called phenol. The goal is to see which works better and is safer. Abo…

This study looks at two different non-surgical treatment plans for knee osteoarthritis in 300 military health system patients aged 18-60. The goal is to see which approach better improves physical function and reduces pain over one year. Participants will follow guidelines from t…

This study tests whether a home-based virtual reality system can help people with knee osteoarthritis do their physiotherapy exercises in a more engaging way. Fifty adults aged 45 and older with knee pain will be randomly assigned to either the VR program or standard physiotherap…

This early-stage study tests a new gel containing ketoprofen, applied to the skin, for people with knee osteoarthritis. The goal is to see if it reduces pain and improves knee function. Forty adults with knee osteoarthritis will be randomly assigned to receive the gel or a compar…

This study tests whether freezing specific nerves around the knee before total knee replacement surgery can reduce pain and the need for opioids afterward. One hundred adults scheduled for knee replacement will either receive the nerve-freezing treatment or a sham procedure. The …

This study tests whether phone coaching and financial rewards can help people become more active after total knee replacement. 600 adults aged 40-85 will be split into three groups: usual care, activity tracker only, or activity tracker plus coaching and rewards. The goal is to s…

This study tests a new procedure called genicular artery embolization (GAE) against standard steroid injections for people with knee osteoarthritis. The goal is to see if blocking certain arteries with tiny beads can provide better pain relief than steroid shots. The trial involv…

This study tests whether a treatment called dorsal root ganglion stimulation (DRG-S) can reduce chronic knee pain caused by osteoarthritis. About 30 adults with long-term knee pain who have not had surgery or are not good candidates for it will receive a device that sends mild el…

This study tests whether an AI chatbot can help people with hip or knee osteoarthritis feel less conflicted and anxious about their treatment choices. About 100 adults with osteoarthritis will chat with the AI before seeing their surgeon. Researchers will measure changes in decis…

This study tests whether platelet-rich plasma (PRP) injections into the knee can change certain proteins in the blood of people with knee osteoarthritis. About 60 participants aged 18-70 will receive either PRP or a saltwater placebo, and researchers will compare protein levels t…

This study looks at whether the number of pain sites or the type of pain (constant vs. intermittent) is linked to physical function in people with knee osteoarthritis. Researchers will measure function with a chair stand test and pain with questionnaires and pain drawings. The go…

This study looks at how seeing or not seeing affects knee joint position sense in people with knee osteoarthritis. Researchers will measure how accurately 120 participants can position their knee with and without visual input. The goal is to better understand how the brain senses…

This study looks at how physical, psychological, and movement-related factors work together in adults with chronic knee pain. By tracking these factors over time, researchers hope to understand why pain experiences differ between people. The goal is to develop practical tools tha…

This study aimed to test different regional anesthesia techniques to help people recover faster and go home sooner after total knee replacement. It planned to compare a standard pain injection with an added nerve block or continuous nerve block infusion. However, the study was wi…

This study reviewed records of 166 knee replacement patients who received a nerve block for pain. Researchers compared pain scores 6-24 hours after the block wore off between two groups: one that received extra education about pain management before surgery and one that did not. …

This study looks at whether adding an extra nerve block to the usual pain block can reduce inflammation after total knee replacement. Researchers will measure inflammation markers in the blood of 60 adults. The goal is to see if this approach leads to less pain medicine use and b…

This study looks at whether using a patient decision aid during doctor visits helps people with severe hip or knee osteoarthritis make better choices about surgery. Researchers will track how informed patients feel, their involvement in decisions, and their pain, function, and qu…

This study compares having both knees replaced at the same time versus one after the other in people with knee osteoarthritis. About 224 participants will be randomly assigned to one approach. Researchers will track recovery, joint function, and quality of life to help guide pati…

This study looks at how hot bone gets during total knee replacement surgery when using a burr (robotic) versus a saw (conventional). Twenty patients will have their bone temperature measured with an infrared thermometer during the procedure. The goal is simply to compare the heat…

This study follows 124 golfers who have hip, knee, or shoulder replacement surgery. Researchers track how many return to golf, how long it takes, and how their game and joint function change over a year. The goal is to give patients and doctors clear, realistic expectations about…

This study looks at 150 people with knee osteoarthritis to see how often night pain and nerve pain (neuropathic pain) occur together. Researchers will use questionnaires and physical exams to measure pain and sleep quality. The goal is to better understand these pain types and th…