KNEE OSTEOARTHRITIS

This study tests whether injecting stem cells from umbilical cords can help people with knee osteoarthritis. The goal is to reduce pain and improve knee function, not to cure the disease. About 100 adults aged 40 to 70 will receive either the stem cells or a placebo, and research…

This early-stage study tests a new gene therapy called BBM-A101 for people with moderate knee osteoarthritis. The goal is to see if it is safe and can help reduce pain or improve joint function. About 81 adults with knee arthritis will receive the treatment and be monitored for s…

This study is testing a new knee replacement system called Persona Revision in 380 adults who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. Participants will be followed for 2 years after surgery.

This study tests if a special treadmill training program before total knee replacement surgery can help prevent falls afterward. People planning knee surgery will either get fall-prevention tips alone or tips plus two weeks of treadmill training that mimics tripping. Researchers …

This study compares two knee braces for people with knee osteoarthritis that affects the inner part of the knee. Researchers want to see if the braces reduce pain during walking and improve how the knee moves. About 30 adults aged 40-85 with moderate knee pain will wear a brace f…

This study compares two types of knee replacement implants designed to better match each patient's natural knee anatomy and movement. The goal is to see which implant helps people feel more like their knee is their own after surgery. About 120 adults needing a first knee replacem…

This study tests a procedure called genicular artery embolization (GAE) to see if it can reduce knee pain and inflammation in adults with knee osteoarthritis. Researchers will compare knee fluid samples and MRI scans before and after the procedure to see if changes in inflammatio…

This study tests which imaging method—fluoroscopy (X-ray) or ultrasound—works better for a procedure called cooled radiofrequency ablation that targets nerves around the knee to reduce pain. The goal is to improve pain relief and function in people with knee osteoarthritis who ha…

This study tests whether doing supervised exercise and learning about your knee before total knee replacement surgery leads to better recovery, less joint awareness, and higher satisfaction one year later. About 110 adults with knee osteoarthritis awaiting surgery will be randoml…

This study tests a new way to treat nerve pain in people with advanced knee osteoarthritis. Instead of taking pills that can cause side effects, the medicine is delivered through the skin using ultrasound, combined with calf muscle stretches. The goal is to reduce burning or ting…

This study tests whether a new knee injection, combining hyaluronic acid with fibrinogen, can safely reduce pain and improve movement in people with knee osteoarthritis. About 31 adults aged 45 to 75 with knee arthritis will receive the injection and be followed for several month…

This study tests a new knee injection called ALLOHEAL for people with knee osteoarthritis. The injection contains natural substances to reduce friction in the joint and ease pain. About 286 adults aged 40 to 79 will receive either ALLOHEAL or a similar treatment to see if it work…

This study tests two different ways to numb the knee after total knee replacement surgery. Both methods use a standard block for the front of the thigh, then add either a block near the tailbone or a block behind the knee. The goal is to find which combination provides longer pai…

This study tests whether an artificial intelligence (AI)-assisted exercise app can reduce pain and improve knee function better than a standard paper exercise program. About 84 adults with knee osteoarthritis will use either the AI app or a paper handout for 6 weeks. The AI app a…

This study tests whether a single injection of hydrolyzed collagen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 204 adults with knee cartilage damage who have not improved with other treatments will receive either the collagen injec…

This study looks at whether a 3-week thermal spa treatment at Enghien-les-Bains can reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare results from 76 participants aged 50-80 to a similar group that received standard care. The goal…

This study tests whether a gentle massage technique (Bowen technique) combined with backward walking can improve hamstring flexibility, reduce pain, and boost mobility in people with knee osteoarthritis. Researchers will enroll 36 adults aged 40-60 with mild to moderate knee arth…

This study tests whether platelet-rich plasma (PRP) injections work better than hyaluronic acid (HA) injections for people with advanced knee osteoarthritis (grades III or IV). The goal is to reduce pain and improve knee function, especially for those who cannot have surgery. Abo…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can help reduce both knee arthritis pain and depression in older adults. Thirty volunteers aged 50 and older with chronic knee pain and moderate-to-severe depression will receive rTMS whil…

This study tests two different ways to numb the back of the knee after total knee replacement surgery. Both methods are combined with a standard front-of-thigh block. The goal is to see which approach provides better pain control, helps patients move sooner, and improves overall …

This study tests whether hyaluronic acid injections into the knee can reduce pain and inflammation in people with knee osteoarthritis. Researchers will measure changes in inflammatory markers and ask 50 participants aged 45-75 about their pain and quality of life. The goal is to …

This study compares two treatments for knee osteoarthritis: a nerve block injection and standard physical therapy. Researchers want to see which one better reduces pain, improves mobility, and helps balance. About 66 adults aged 40-70 with knee pain for at least 3 months will tak…

This study tests whether custom-made knee replacements, designed from each patient's CT scans and made with 3D printing, fit better and cause less pain than standard off-the-shelf implants. About 20 adults aged 40-70 with knee osteoarthritis will be randomly assigned to get eithe…

This study tests whether adding dexamethasone or dexmedetomidine to standard numbing medicine can reduce the need for strong painkillers after knee replacement. About 96 older adults will be randomly assigned to one of three groups to compare pain relief and side effects. The goa…

This study looks at whether a structured physical therapy program can improve how people walk and distribute weight on their feet after total knee replacement surgery. Researchers will measure walking patterns and foot pressure before and after the program in 30 women aged 40-70.…

This study compares an 8-week yoga program to standard therapeutic exercise in 90 adults aged 45+ with knee osteoarthritis. Researchers will measure changes in pain, balance, daily function, and quality of life. The goal is to see if yoga offers meaningful benefits for managing k…

This study looks at the best ways to start group physical therapy for veterans with knee osteoarthritis at 20 VA medical centers. About 20 sites will join to see which approach helps more veterans begin and stick with the program. The goal is to make it easier for veterans to get…

This study tests whether giving duloxetine, an antidepressant that also eases pain, before and after knee replacement surgery can lower the need for opioids. About 150 adults with knee osteoarthritis will take duloxetine or a placebo around their surgery. The goal is to improve p…

This study tests whether a newer anesthetic drug, remimazolam, causes less confusion (delirium) after hip or knee surgery in elderly patients compared to the standard drug propofol. Researchers will enroll 82 older adults undergoing these surgeries and check for confusion three d…

This study tests a single injection of a new drug (4P004) for people with knee osteoarthritis and joint swelling (synovitis). About 129 adults aged 40-80 will receive either the drug or a placebo. The main goal is to see if it reduces daily knee pain over 4 weeks.

This study tests whether adding a sugar solution (dextrose) to numbing injections around knee nerves provides better pain relief than numbing medicine alone for people with chronic knee osteoarthritis. Sixty adults with knee arthritis will receive a series of three injections tar…

This study tests a non-drug approach for people with knee osteoarthritis and low back pain. For two weeks, participants will have a cuff on one thigh that briefly stops blood flow for 5 minutes at a time, repeated over 50 minutes every other day. The goal is to see if this improv…

This study looks at whether playing video-game based exercises can improve knee function and keep people with knee osteoarthritis more engaged than standard physical therapy. Sixty adults with knee osteoarthritis will do 10 weeks of exercises, some using a special game with senso…

This study looks at whether adding a sleep improvement program to personalized exercise coaching can reduce knee pain more than exercise alone. About 288 older adults with knee osteoarthritis and insomnia will take part remotely. The goal is to see if treating both pain and sleep…

This study looks at two types of injections for knee osteoarthritis pain: one uses a sugar solution (dextrose) and the other uses a numbing medicine (local anesthetic). About 86 adults with knee pain for at least 3 months will receive one of these injections and be followed for 6…

This study tests whether a hands-on technique called gastrocnemius myofascial release (a type of calf muscle massage) can reduce pain and improve movement in women with knee osteoarthritis. Thirty women aged 45-55 with mild to moderate knee arthritis will receive either the real …

This study tests whether adding foot massage to standard cold therapy can reduce pain, improve satisfaction, and lower painkiller use in 60 adults after knee replacement surgery. Participants are randomly assigned to receive either cold therapy alone or cold therapy plus foot mas…

This study tests whether a magnesium supplement called Magnesium-L-Threonate can help people sleep better and feel less pain after total knee or hip replacement surgery. About 64 adults having surgery at the University of Miami will take the supplement or a placebo. The goal is t…

This study tests whether high-intensity pulsed electromagnetic field therapy can reduce pain and improve strength in older adults with knee osteoarthritis. About 64 people aged 60 and older will receive the therapy on their knee or both knee and thigh, plus a home exercise progra…

This study tests whether a new, more concentrated growth factor injection (SRF) works better than standard PRP for knee osteoarthritis. About 90 adults with mild to moderate knee arthritis will receive one of the two injections. The goal is to see if SRF provides greater pain rel…

This study tests whether a 10-week telehealth program that combines gentle exercise with mindfulness can help people with knee osteoarthritis feel better. About 66 adults with knee pain will be randomly assigned to either the mindful exercise group or an exercise-only group. All …

This study tests if injecting a sugar-water solution (dextrose) into specific spots seen on an MRI works better than injecting it into the joint space for knee osteoarthritis. About 60 adults aged 45-80 with moderate knee arthritis will receive either MRI-guided or standard injec…

This study compares two methods of knee replacement surgery: mechanical alignment (traditional, neutral position) and kinematic alignment (mimics natural knee position). About 95 adults with knee arthritis will be randomly assigned to one method. The goal is to see which approach…

This study looks at whether a hands-on technique called Mobilization with Movement (MWM) can reduce pain and inflammation in people with knee osteoarthritis. Forty adults with moderate to severe knee OA will receive either MWM or a fake version, plus standard care, twice a week f…

This study looks at why some people with knee osteoarthritis get more pain relief from a topical gel (diclofenac) than others. Researchers will track 220 adults aged 50+ over 8 weeks, collecting questionnaires and blood samples. The goal is to see if patient traits, clinic visit …

This study tests whether a pre-surgery exercise program (prehabilitation) helps people waiting for hip or knee replacement. Researchers will measure quality of life, mobility, and mental health in 44 adults with osteoarthritis. The goal is to see if this simple, drug-free approac…

This study looks at whether taking collagen peptide supplements before total knee replacement surgery can improve tissue healing, strength, and recovery. About 44 adults aged 50-75 with knee osteoarthritis will take collagen or a placebo for 8 weeks before surgery. Researchers wi…

This study tests whether a mobile app can help people recovering from hip, knee, or spine surgery do simple exercises while still in bed. About 100 adults will use the app to guide their in-bed conditioning, and researchers will measure how well they perform in physical therapy a…

This study tests whether adding shock wave therapy to knee exercises reduces pain and improves function better than exercises alone in people with knee osteoarthritis. About 40 adults with moderate knee pain will participate during a hospital stay, receiving either exercises plus…

This study looks at whether adding low-level laser therapy to a home exercise program can reduce pain and improve knee function in people over 50 with knee osteoarthritis. It also checks if the laser helps thicken thigh muscle and knee cartilage. About 62 participants will be ran…

This study tests a single injection made from donated human placental tissue (PTP-001) to see if it improves pain and function in people with knee osteoarthritis. About 260 adults aged 40 to 80 with mild to moderate knee OA will receive either the injection or a placebo and be fo…

This study looks at two different ways to align a new knee joint during robotic-assisted knee replacement surgery. About 240 people with knee osteoarthritis will be randomly assigned to one of two alignment methods. The goal is to see which approach helps patients feel more natur…

This study looks at two different ways to give a nerve block (adductor canal block) for pain after total knee replacement surgery. The goal is to see which method provides better pain control and helps patients get up and move sooner. About 78 adults having knee replacement will …

This study tests whether a single injection of cells from bone marrow or from fat tissue can better reduce pain and improve knee function in people with knee osteoarthritis. Researchers will enroll 204 adults aged 40 to 75 who have not gotten relief from standard treatments. The …

This study tests whether CartiPRO, an approved collagen injection, can safely reduce knee pain in people with osteoarthritis or cartilage damage. About 194 adults will receive two injections 24 weeks apart. Researchers will measure pain, knee function, and quality of life over 36…

This study tests whether focused shockwave therapy can safely reduce knee pain and improve function in people with osteoarthritis who also have bone marrow lesions. Fifteen adults with persistent knee pain will receive four weekly shockwave sessions or standard care (pain relieve…

This study looks at how the angle of your knee bones (seen on X-rays) relates to pain, daily function, quality of life, and fear of moving in people with knee osteoarthritis. Researchers will measure these factors in 100 adults using questionnaires and X-ray readings. The goal is…

This study is creating a registry of up to 100 adults with knee osteoarthritis to track how well a procedure called genicular artery embolization (GAE) reduces pain over 12 months. Participants have had knee pain for over 6 months that hasn't improved with standard treatments lik…

This study is a large registry that will follow 10,000 people with knee osteoarthritis to see how well different pain treatments work. Participants may receive injections, nerve blocks, or other therapies. The goal is to collect real-world data on pain relief, function, and side …

This study looks at how the shape and alignment of the kneecap joint relate to knee pain. Researchers will use special CT scans taken while standing to see the knee in a natural position. The goal is to find links between specific knee features and symptoms, which could help doct…

This study is testing whether an app called Genus can help people with knee osteoarthritis learn more about their condition and feel more confident in making treatment decisions. About 204 adults over 50 who are waiting to see a knee specialist will either use the app for 8 weeks…

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) to treat early knee arthritis. Researchers want to see how the surgery affects the kneecap joint and patellar height over many years. The goal is to better understand long-term outcomes and help…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery. Researchers check in at 6 weeks, 3 months, 6 months, and 12 months after surgery to see if and how they return to golf. The goal is to learn more about the recovery process and what helps golfers …

This study compares two types of anesthesia—general (you are fully asleep) and spinal (you are awake but numb from the waist down)—for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications in about 2…

This study uses special wearable sensors to measure how well people with severe knee osteoarthritis can move their knee before and after getting a total knee replacement. Researchers will track 20 adults over age 60 to find simple movement patterns that could help doctors better …

This study looks at how a person's neighborhood resources affect their recovery after knee replacement surgery. Researchers will use a remote monitoring device to track physical progress and compare it to standard care. The goal is to see if remote monitoring can reduce the numbe…

This study aims to find biological markers in blood and joint fluid that can predict how knee osteoarthritis will progress and whether treatments like steroid injections will work. Researchers will follow 200 people with knee osteoarthritis and 100 with other inflammatory joint c…

This study is testing a smartphone app that tracks movement and symptoms in people before and after knee or hip replacement surgery. The goal is to create a score that helps predict which patients will be satisfied with their surgery. About 1,250 adults in Germany will participat…

This study aims to create and validate an Italian version of the New Knee Society Knee Scoring System, a questionnaire that measures knee function and symptoms in people with knee osteoarthritis. Researchers will translate the English version into Italian and test it with 200 pat…

This study looks at 300 people with severe knee arthritis and a bow-legged (varus) deformity who are getting a total knee replacement. Researchers will use special CT scans to measure the leg's natural alignment and compare it to the healthy side. The goal is to find the best way…

This study aims to see if artificial intelligence (AI) can use information collected before surgery—like genetics, behavior, and physical function—to predict how well people recover after total knee replacement. Researchers will enroll 197 adults with severe knee osteoarthritis a…

This study looks at 180 people with knee osteoarthritis to see if brain scans, knee MRIs, and pain tests can predict who will get good pain relief from duloxetine, celecoxib, or a placebo. Participants take one of these pills for about 20 weeks and report their pain levels. The g…

This study follows 150 adults aged 18–70 who had knee osteotomy surgery to treat osteoarthritis caused by a crooked leg (bow-legged or knock-kneed). The goal is to see how well the knee works and feels over many years, and whether this bone-cutting technique can successfully dela…

This study looks at whether special insoles that measure how you walk, along with other health information, can predict how much your knee will improve after replacement surgery. About 200 adults with knee osteoarthritis scheduled for surgery will participate. The goal is to help…

This pilot study tests a new instrument to help surgeons balance the knee's main ligament (MCL) during total knee replacement. The goal is to see if the tool makes the procedure more consistent and repeatable. About 40 adults with knee osteoarthritis who need a knee replacement w…