KNEE OSTEOARTHRITIS

This study tested a single injection of a drug called lorecivivint in the knee joint of 501 people with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function over 56 weeks compared to a placebo. Participants were adults aged 40-80 wi…

This study looked at the long-term safety and benefits of using a patient's own fat-derived cells (stromal vascular fraction) to treat knee osteoarthritis. Sixteen people with moderate knee arthritis received a single injection into the knee and were followed for 10 years. The go…

This study tested a therapy called Cognitive Muscular Therapy (CMT) for people with knee osteoarthritis who are waiting for a knee replacement. The goal was to see if CMT could reduce pain and improve function. 36 adults over 40 took part. The therapy focuses on changing how you …

This study tested whether using a smartphone app (TRAK) to guide and monitor exercises at home could improve pain and function in people with knee osteoarthritis, compared to doing the same exercises without the app. Fifty adults over 45 with knee pain took part. The goal was to …

This study tested whether using a stationary bike with biofeedback (real-time cues about movement) can improve deep sensation and physical function in older adults with knee osteoarthritis. Forty participants with mild to moderate knee OA completed the trial. The goal was to see …

This study looked at whether adding two specific hands-on therapies (Muscle Energy Technique and Mulligan Mobilization) to standard physical therapy can improve hamstring flexibility and reduce daily limitations in people with knee osteoarthritis. Twenty-four adults aged 40 and o…

This study looked at whether adding platelet-rich plasma (PRP) injections to an exercise program helps people with knee osteoarthritis more than exercise alone. 84 adults aged 40-70 with moderate knee arthritis took part. Researchers measured pain, stiffness, and physical functio…

This study tested a robot device that helps people with knee osteoarthritis do rehab exercises at home after knee replacement surgery. Ten adults used the device for one month to see if it improved leg strength and knee function. The goal was to make recovery easier and faster, r…

This study tested two different ways of preparing platelet-rich plasma (PRP) injections for people with knee osteoarthritis. The goal was to see which method better reduces pain, improves daily function, and enhances quality of life. 96 adults with mild-to-moderate knee arthritis…

This study looked at whether a nasal spray containing oxytocin, a natural hormone, can help reduce pain and improve daily function in older adults with knee osteoarthritis. Over 4 weeks, 83 participants used either the oxytocin spray or a placebo. The main goal was to measure cha…

This study tested a special nerve block called a para-sartorial compartment block to control pain after knee surgery. 60 adults having knee surgery under spinal anesthesia received the block to see if it reduces pain and the need for extra painkillers like tramadol. The block aim…

This study tested whether adding a special ultrasound treatment to vibration massage helps loosen tight calf muscles in people with knee osteoarthritis. Sixty adults aged 40 to 60 with moderate knee OA took part. They were split into three groups: one got standard care, another a…

This study tested whether a very low dose of radiation therapy can safely reduce pain and improve knee function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis took part. The main goal was to see if more participants reported significant pai…

This study tested whether resveratrol, a natural compound found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took resveratrol or a placebo daily for three months. The main goal was to see if pain scores improve…

This study tested whether an injection called CCoat can reduce pain in people with mild to moderate knee osteoarthritis. 125 adults received either CCoat or a placebo shot, and their pain was tracked for up to six months. The goal was to see if CCoat provides better pain relief t…

This study tested a procedure called geniculate artery embolization to treat knee pain from moderate to severe osteoarthritis. Doctors injected tiny permanent beads into blood vessels around the knee to block blood flow and reduce pain. Nine adults aged 40-80 who had not gotten r…

This study tested two types of balance exercises—whole-body vibration therapy and balance board training—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which method worked better. The goal was to…

This study tested a procedure called Subchondroplasty (SCP) done with arthroscopy versus arthroscopy alone for people with knee pain from bone marrow lesions. About 131 adults aged 30-75 with mild to moderate knee osteoarthritis took part. The goal was to see if SCP plus arthrosc…

This study tested two different ultrasound methods combined with standard physical therapy for people with knee osteoarthritis. 46 adults with knee pain and stiffness took part. The goal was to see which technique better reduces pain and improves function. Results may help doctor…

This study tested different non-surgical treatments to reduce pain and improve daily function in 1,937 people with knee osteoarthritis. The goal was to find effective alternatives to opioids for long-term pain management. Results help doctors choose the best treatment for each pa…

This study looked at whether using different amounts of numbing medicine in a nerve block (called an adductor canal block) can better control pain after total knee replacement surgery. 90 adults having knee replacement took part. The main goal was to see how much pain medicine th…

This study tested whether adding a treatment called radial extracorporeal shock wave therapy (a type of sound wave therapy) to a standard exercise program helps people with knee osteoarthritis feel less pain and walk better. 72 adults aged 50-85 with knee osteoarthritis took part…

This study tested whether an injection made from donated amniotic tissue (the sac around a baby) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with knee arthritis received either the amniotic injection or a placebo (fake injection). The …

This study tested whether adding dexamethasone or dexmedetomidine to a nerve block could extend pain relief after total knee replacement. 90 adults undergoing knee surgery received one of the two additives. The main goal was to see how long it took before they needed opioid pain …

This study tested two types of nerve blocks to control pain after total knee replacement. 62 patients received either a newer para-sartorial block or a standard femoral-sciatic block. Researchers measured how much extra pain medicine was needed and how well patients could move th…

This study looked at whether a hands-on movement therapy called Mulligan mobilization can help people with knee osteoarthritis. 36 adults aged 50-70 with moderate knee pain participated. Researchers measured pain, muscle activity, and sensory changes to see if this approach impro…

This study tested whether a smartphone app (ARTHE-e) helps people with knee osteoarthritis follow their exercise plan better than standard care. About 120 adults aged 40-85 with knee osteoarthritis participated. The app provides guidance and reminders to support exercise adherenc…

This small pilot study tested whether adding group-based pain neuroscience education (PNE) to a community exercise program could help older women with knee osteoarthritis. Nineteen women aged 60+ took part in either exercise alone or exercise plus five PNE sessions over 10 weeks.…

This study compared two physical therapy techniques—Mulligan's Pain Release Phenomenon and Kaltenborn Mobilizations—for people with early knee osteoarthritis. 44 adults aged 40-65 received one of the two treatments plus standard exercises for six weeks. The goal was to see which …

This study tested whether a standardized education and exercise program before total knee replacement surgery helps patients recover function faster. 262 adults aged 50-85 with knee osteoarthritis took part. The program aimed to improve the ability to walk, transfer, and climb st…

This study tested two manual therapy techniques—myofascial release and strain counter strain—in 44 adults aged 40 to 65 with knee osteoarthritis. The goal was to see which approach better reduces pain, improves movement, and boosts quality of life. Participants had grade 2 osteoa…

This study looked at whether taking an oral supplement containing hyaluronic acid along with getting a hyaluronic acid injection in the knee provides more relief for knee osteoarthritis than the injection alone. 44 people aged 60-75 with knee arthritis took the supplement or a pl…

This study tested a special tai chi program that uses real-time feedback to help people with knee osteoarthritis move in ways that reduce stress on their knees. Fifteen adults aged 40 and older with knee pain completed the 4-week program. Researchers measured changes in knee join…

This study looked at two different nerve blocks—adductor canal block and pericapsular nerve group block—to see which one provides better pain relief after total knee replacement. Sixty adults having knee surgery under spinal anesthesia took part. The goal was to find which block …

This study tested whether injecting a gel called polyacrylamide hydrogel into the knee can reduce pain and improve daily function in people with knee osteoarthritis. A total of 387 patients (593 knees) were treated across three medical centers. Pain and function were measured bef…

This early study tested whether a special injection made from a patient's own blood (called A2MRP) is safe and can help with knee osteoarthritis pain. Twenty adults with moderate knee arthritis received the injection. The main goal was to check for side effects, and researchers a…

This study tested whether using a Fitbit activity tracker, a smartphone app, and brief coaching from a physical therapist could help people with knee osteoarthritis become more active and sit less. Fifty-one participants were split into two groups to compare the program against s…

This study tested whether doing leg exercises with a blood-flow restriction cuff before knee replacement surgery is safe and helpful. Sixteen older adults awaiting total knee replacement took part. The goal was to see if this training could improve muscle strength and function be…

This study tested two different nerve block techniques to manage pain after total knee replacement. Sixty adults aged 65 to 100 took part. The goal was to see which method reduced the need for strong painkillers (opioids) and improved pain scores in the first 48 hours after surge…

This study looked at whether changing the angle of a leg exercise machine (N-K Table) from 0° to 50° helps people with knee osteoarthritis activate their thigh muscles more effectively. 43 women aged 50-65 with knee OA did leg exercises at both angles, and their muscle activity w…

This study tested two types of thigh exercises—eccentric (lengthening) and concentric (shortening)—in 24 women aged 40-59 with knee osteoarthritis. Participants did exercises three times a week for six weeks. The goal was to see which type better improves knee strength, movement,…

This study looked at two home treatments for early-stage knee osteoarthritis: a structured exercise program and a topical diclofenac gel. 83 adults aged 40-70 took part. The goal was to see which approach better reduces pain and improves daily function. Results help doctors recom…

This study tested a new drug called CNTX-6970 in 55 adults aged 40-90 with moderate to severe knee osteoarthritis pain. The goal was to see if the drug safely reduces pain better than a placebo over 24 weeks. Participants used a mobile app to report their pain levels.

This study tested whether L-carnitine, a natural supplement, can reduce pain, stiffness, and improve physical function in people with mild to moderate knee osteoarthritis. 66 adults with knee pain and X-ray evidence of arthritis took either L-carnitine or a placebo. Researchers m…

This study tested whether a treatment called CKD-981 can safely and temporarily reduce knee pain in people with knee osteoarthritis. About 100 adults aged 40 to 80 with moderate to severe knee pain took part. The treatment was compared to a sham (fake) procedure to see if it trul…

This study tested whether a single injection of Hyruan-One into the knee can reduce pain and improve function in people with knee osteoarthritis. 276 adults with knee pain that hadn't improved with other treatments took part. The study compared Hyruan-One to another gel (Hylan G-…

This study looked at how different combinations of exercise affect pain, movement, and joint awareness in people with knee osteoarthritis. 45 adults aged 45-74 with mild to moderate knee arthritis were split into three groups, each doing a mix of strengthening, stretching, and cy…

This study tested a single injection of TTAX03 in the knee for people with severe osteoarthritis (grades 3-4). 90 adults received either the study drug or a placebo (saline). The goal was to see if more people reported significant pain relief or better function after 12 weeks. Th…

This study looked at whether Reiki (a hands-on energy therapy) or mindfulness meditation can help reduce pain and stiffness in people with knee osteoarthritis. 164 adults were randomly assigned to receive Reiki, a fake Reiki treatment, meditation, or no treatment at all. The goal…

This study looked at whether a single-dose gel called CR500™ can keep helping people with knee osteoarthritis over the long term. Researchers followed up with 35 patients who had already been in an earlier study. They measured pain and function using a knee score and asked about …

This study tested a new medicine called LEVI-04 to see if it can reduce pain in people with knee osteoarthritis. About 518 adults with knee pain took either the drug or a placebo. The main goal was to measure pain changes using standard pain scales. The trial is complete, and res…

This study looked at whether motivational interviewing, a counseling style that helps people set and reach their own goals, can increase satisfaction in patients who had knee replacement surgery. About 149 people took part. The goal was to see if this extra support could help the…

This study tested a special injection made from donated amniotic tissue (the sac that surrounds a baby during pregnancy) to see if it could reduce pain and improve function in people with knee osteoarthritis. About 594 adults with moderate to severe knee arthritis who had not got…

This study tested a single injection of lorecivivint in the knee joint of 496 adults with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo over 28 weeks. Participants reported their pain levels weekly using…

This study looked at whether adding the drug duloxetine to a supervised aerobic exercise program could help older adults with both knee osteoarthritis and depression. All 43 participants received the combined treatment to see if it was feasible and if it improved pain and mood. T…

This study tested a new gel called Pandora, made with hyaluronic acid and tranexamic acid, for people with knee osteoarthritis. It compared one injection or three weekly injections of Pandora to a single injection of a standard treatment. The goal was to see if Pandora reduces wa…

This study looked at 377 people with knee osteoarthritis who needed a total knee replacement. It compared what happens when surgeons keep the infrapatellar fat pad (a small pad of fat in the knee) versus removing it. The goal was to see which approach leads to better pain relief,…

This study tested whether a single injection of ACP Max PRP (a concentrated platelet solution from your own blood) can safely ease knee osteoarthritis symptoms. 45 adults with knee arthritis received either the PRP injection or a standard steroid shot. Researchers tracked side ef…

This study tested two different treatments for knee osteoarthritis in 44 adults aged 40-60. One group received a special hands-on therapy called the Fascial Distortion Model, while the other did standard hamstring stretches. Researchers measured pain, stiffness, and physical func…

This study tested an experimental drug called SM04690, given as two injections into the knee about six months apart, in 101 people with moderate to severe knee osteoarthritis. The main goal was to check safety and measure changes in bone density in the treated knee compared to a …

This study tested two types of radiofrequency ablation (a heat-based treatment) to see which works better for people with advanced knee osteoarthritis whose pain didn't improve with other treatments. 26 patients aged 50-80 took part. The goal was to reduce pain and improve daily …

This study tested whether doing supervised leg exercises at home via video calls works as well as doing them in person for people with knee osteoarthritis. Forty-eight adults with knee pain and stiffness took part in a 12-week program. The goal was to see if remote supervision co…

This study looked at whether adding craniosacral therapy (a gentle, hands-on treatment) to a standard home exercise program helps adults with knee osteoarthritis more than exercise alone. Twenty-one participants were split into two groups: one did only home exercises for six week…

This study tested whether adding morphine (a painkiller) to a standard antibiotic injection into the shin bone during knee replacement surgery helps reduce pain afterward. About 100 adults having their first knee replacement took part. Half got the antibiotic plus morphine, and h…

This study looked at whether a special computer system used during knee replacement surgery can measure bone angles as accurately as a CT scan done beforehand. 50 adults with knee arthritis had both a CT scan and the computer measurements during their surgery. The goal was to see…

This study looked at how much people with rheumatoid arthritis (RA) and knee osteoarthritis (KOA) know about heart disease. 120 adults aged 40 and older answered questions about heart disease risk factors and physical activity. The goal was to see if awareness differs between the…

This study looked at whether removing a surgical drain before or after the first physical therapy session affects recovery after total knee replacement. Researchers followed 207 adults with knee osteoarthritis who had knee replacement surgery. The goal was to see if drain timing …

This study looked at how stable a new type of uncemented knee implant is in people with knee osteoarthritis. 31 patients received the implant and were followed for 2 years using special X-rays to measure any movement. The goal was to see if the implant stays firmly in place over …

This study looked at whether a blood enzyme called tryptase can help predict knee stiffness and pain after total knee replacement. Researchers measured tryptase levels before and after surgery in 219 people with knee arthritis. The goal was to see if changes in this enzyme are li…

This study tested whether special X-ray and MRI scans of the bone beneath the knee joint can predict if osteoarthritis will get worse over 3 years. Researchers followed 167 people with knee arthritis, using imaging and bone texture analysis to track changes. The goal is to better…

This study looked at whether a wearable sensor can detect changes in how the knee moves and handles weight after a temporary fluid injection (simulating a knee injury). Fourteen healthy adults aged 18-35 took part. The goal was to see if this inexpensive device could be a useful …

This study looked at whether using a computer to guide knee replacement surgery leads to better results than the traditional method done by hand. About 192 patients aged 50 to 85 with knee arthritis took part. Researchers tracked how long the new knee lasted, how well it worked, …

This study tested a noninvasive navigation system to measure how the knee moves in people with severe knee osteoarthritis before they get a knee replacement. The goal was to see if measuring natural knee motion could help doctors better match implants to each patient. Forty adult…

This study looked at 40 adults with knee arthritis to compare two types of knee realignment surgery. The goal was to see which method keeps the important blood vessels behind the knee safer. Researchers used CT scans to measure the distance from the surgical cut to these vessels.…

This study tested whether custom-made cutting guides, designed from each patient's CT scan, can improve the accuracy of knee replacement surgery. Researchers compared the positioning of the implants to standard techniques in 20 patients with end-stage knee osteoarthritis. The goa…

This study analyzed data from 62 people with knee osteoarthritis who received radial pressure wave therapy. Researchers looked at factors like age, weight, and pain levels to see which patients had the best improvement after six months. The goal is to help doctors predict who wil…

This study looked at 800 people with hip or knee osteoarthritis to see if different patient questionnaires can be linked together. The goal was to help doctors compare results across studies and find out what score change actually matters to patients. No new treatment was tested;…

This study tested updated features of the ROSA Knee System, a robot used during knee replacement surgery. Forty adults having knee replacement took part. The goal was to check if the new features were safe and easy for surgeons to use, not to cure or treat the disease.

This study looked at two different ways surgeons align a new knee implant during total knee replacement. 52 adults with knee osteoarthritis were randomly assigned to one of two alignment methods. The goal was to see which technique leads to less implant movement over the first tw…

This study looked at whether placing a drain after knee replacement surgery affects how much hemoglobin drops and whether a blood transfusion is needed. 102 adults having knee replacement took part, with half getting a drain and half not. Researchers measured hemoglobin before su…

This study looked at how stable a new knee implant (GMK Sphere) is in people with knee osteoarthritis. Researchers used a special X-ray technique to measure any tiny movements of the implant over 5 years. The goal was to gather information that could help design better, longer-la…

This study tested a new exercise program using visual feedback to help people load their knee properly after ACL surgery. The goal was to see if this could prevent knee arthritis, which often develops within 15 years after an ACL injury. 34 participants were followed for 6 months…

This study followed 41 people who had a scaffold implanted to treat partial meniscus tears in the knee. Researchers collected data from medical records and phone interviews to see how patients' pain, knee function, and quality of life changed over time. The goal was to understand…