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New heat treatment may offer better knee pain relief for arthritis sufferers

NCT ID NCT06863181

Symptom relief Sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two types of radiofrequency ablation—a procedure that uses heat to calm pain-signaling nerves—in 26 people with advanced knee osteoarthritis whose pain didn't improve with standard treatments. The goal was to see which method, conventional or cooled, better reduces pain and disability. Results could help doctors choose the best option for long-lasting relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radiofrequency ablation (heat-based nerve treatment)
What this could lead to
If successful, this could point toward a more effective, longer-lasting pain relief option for people with severe knee osteoarthritis who haven't responded to other treatments.
What could go wrong
This is a small, completed study with only 26 participants, so results may not apply to everyone. Radiofrequency ablation carries risks like temporary numbness or pain, and the effect may wear off over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

26 people

The number who actually took part.

Started

Feb 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Knee pain lasting more than 6 months * Age between 50 and 80 * Diagnosis of radiographically proven grade III or IV knee osteoarthritis according to the Kellgren-Lawrence Grading Scale, marked narrowing of the medial compartment of the tibiofemoral joint space * Presence of pain resistant to conservative treatment * Exercise * Physical therapy agents * Use of oral anti-inflammatory agents Exclusion Criteria: * History of trauma to the knee area * History of knee surgery * Presence of systemic inflammatory disease affecting the knee joint * Presence of peripheral neuropathy or radiculopathy * Pregnancy * Hemodynamic instability * Presence of skin or soft tissue infection at the injection site * Refusal to participate in the study * Presence of acute knee pain with accompanying inflammatory findings * Presence of a serious psychiatric disorder or neurological disease Having received an intra-articular injection within the last 3 months

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • Gaziler Physical Medicine and Rehabilitation Training and Research Hospital

    Ankara, Çankaya, 06800, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.