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New study tests Longer-Lasting nerve block for knee arthritis pain

NCT ID NCT07267039

Symptom relief Sponsor: Salim Sencar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 2 times

Summary

This study looks at two types of ultrasound-guided injections for people with knee osteoarthritis who haven't gotten relief from standard treatments like pills or physical therapy. One injection uses a chemical called phenol to block pain signals for a longer time, while the other uses a numbing medicine and steroid to reduce pain and swelling. The goal is to see which works better for pain and daily function, and how safe each is. The study includes 42 adults aged 40 and older with moderate to severe knee pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

42 people

The number who actually took part.

Started

May 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients (≥40 years) diagnosed with moderate to severe knee osteoarthritis (Kellgren-Lawrence grade 3-4) who did not benefit from conservative treatments such as medications and physical therapy. A total of 42 patients are enrolled and treated at the Physical Medicine and Rehabilitation Department, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 40 years * Diagnosis of knee osteoarthritis (Kellgren-Lawrence grade 3-4) confirmed by radiographic evaluation * Moderate to severe knee pain for at least 3 months (VAS ≥ 4) * Inadequate response to conservative treatments (e.g., medications, physical therapy, exercise) * Ability to provide informed consent Exclusion Criteria: * History of knee surgery (e.g., total knee arthroplasty) on the affected side * Intra-articular injection (hyaluronic acid, corticosteroid, PRP, etc.) within the last 6 months * Secondary arthritis (e.g., rheumatoid arthritis, gout, septic arthritis, trauma-related arthritis) * Severe coagulopathy or current use of anticoagulant therapy contraindicating injection * Local skin infection at the injection site * Known allergy or contraindication to phenol, bupivacaine, or triamcinolone acetonide * Severe uncontrolled systemic disease (e.g., advanced cardiac, hepatic, or renal failure) * Pregnancy or breastfeeding

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Genicular nerve block Knee osteoarthritis

Contacts and locations

Locations

  • Ondokuz Mayis University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation

    Samsun, 55139, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.