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Knee pain relief: which PRP injection works best?

NCT ID NCT04807270

Symptom relief Sponsor: Istanbul University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two different ways of preparing Platelet-Rich Plasma (PRP) injections for people with knee osteoarthritis. 96 participants received three injections over six weeks and were followed for six months. The goal was to see which method better reduces pain, improves function, and enhances quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-Rich Plasma (PRP) injection
What this could lead to
If successful, this could show which PRP preparation method works better for easing knee pain and improving mobility in osteoarthritis.
What could go wrong
This is a small, completed trial with no phase designation, so results may not apply widely. PRP is a common treatment but its effectiveness is still debated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

96 people

The number who actually took part.

Started

May 2021

Finished

Jan 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with chronic symptomatic knee pain between the ages of 30 and 75 years * Presence of Kellgren-Lawrence stage 2-3 osteoarthritis on current anterior-posterior knee radiographs * The ability to walk independently Exclusion Criteria: * Previous treatment with an autologous blood product or stem cell preparation * Severe knee effusion * Concomitant severe meniscus or ligament injury * Recent cancer or other tumors * History of knee surgery * Previous diagnosis of a neuromuscular, infectious, or inflammatory disease * Bleeding disorders and/or use of warfarin * Body mass index above 40 kg/m² * Cardiac or systemic diseases that could affect participation in the exercise program

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation

    Istanbul, Fatıh, 34034, Turkey (Türkiye)

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