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Knee gel injection eases arthritis pain in 387-Patient study

NCT ID NCT07193368

Symptom relief Sponsor: Feza Korkusuz MD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a single injection of polyacrylamide hydrogel (Arthrosamid®) into the knee joint of 387 people with knee osteoarthritis. Researchers measured pain and physical function over 12 months. The goal was to see if the gel could reduce pain and improve everyday movement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
polyacrylamide hydrogel (Arthrosamid®)
What this could lead to
If confirmed, this injection could offer a non-surgical option to ease knee pain and improve daily function for people with osteoarthritis.
What could go wrong
This was a retrospective study without a placebo group, so results may be less reliable. Long-term safety and effectiveness beyond 12 months are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

387 people

The number who actually took part.

Started

Feb 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients aged 40 years and older diagnosed with knee osteoarthritis (KL grade 2-4) who were treated with a single intra-articular polyacrylamide hydrogel injection at three medical centers in Türkiye and followed retrospectively for 12 months.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 40 years * Radiographic diagnosis of knee osteoarthritis (Kellgren-Lawrence grade 2-4) * Received intra-articular 2.5% polyacrylamide hydrogel injection Exclusion Criteria: * Prior knee surgery before PAAG injection * Malignancy, local infection, or septic arthritis * Inflammatory joint disease (e.g., rheumatoid arthritis) * Pregnancy * Avascular necrosis * Advanced varus or valgus knee deformity

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Degenerative joint disease of the knee Knee osteoarthritis Osteoarthritis Osteoarthritis of the knee

Contacts and locations

Locations

  • Hacettepe University, Faculty of Medicine, Department of Sports Medicine

    Ankara, Turkey (Türkiye)

More trials for these conditions

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