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New combo therapy eases stiff calves in knee arthritis patients

NCT ID NCT07256054

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding high-power pain threshold ultrasound and vibration massage to standard treatment could help with calf muscle tightness in people with knee osteoarthritis. Sixty patients with moderate knee OA were split into three groups: standard care alone, standard care plus vibration, or standard care plus both vibration and ultrasound. The researchers measured calf flexibility, pain, and knee function before and after 12 sessions over four weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-power pain threshold ultrasound and vibration massage
What this could lead to
If it works, this could offer a simple, non-drug way to ease calf tightness and improve knee function in people with knee osteoarthritis.
What could go wrong
This is a small, completed trial with only 60 participants, so results may not apply to everyone. The outcomes are short-term and the treatment is an add-on, not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jun 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age from 40 to 60 years' patients of chronic knee OA 2. Patient with unilateral knee OA grade II-III Kellgren and Lawrence (K/L) 3. Patients with BMI \< 30 kg/m² (not being classified as obese). 4. Patients who are able to walk with painful knee OAwithoutassistive devices. 5. Patients with knee pain intensity level at least \>3 cm on a 10 cm. VAS scale in activities such as going up-and downstairs, sitting and squatting. Exclusion Criteria: * Radiated pain from low back pain. * No radiographic evidence of knee OA or with mild OA (grade I according to K/L classification) or with severe OA (grade IV according to K/L classification). * Bilateral knee OA. * Loss of joint play in tibiofemoral and patellofemoral articulations. * Lower extremity fracture and surgery or trauma to the knee joint. * Neurological deficit or movement disorder related to lower limb. * Athletes or who had been treated with physiotherapy or medications during the previous 6 weeks. * Those who could not apply vibration and percussion stimuli. * Those who had varicose veins.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Physical Therapy faculty, Cairo University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.