Gentle moves may ease knee pain: new study shows promise
NCT ID NCT06527313
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a movement therapy called Mulligan mobilization in 36 people with knee osteoarthritis. The goal was to see if it could reduce pain and improve how muscles work. Participants were aged 50 to 70 with moderate knee pain. The therapy involves gentle, repeated movements guided by a therapist.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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36 people
The number who actually took part.
- Started
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Jul 2024
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosing knee OA according to the American College of Rheumatology (ACR) criteria (Primary knee OA diagnosis) * Stage 2 or 3 patients according to Kellgren-Lawrence radiological staging criteria * Patients with a disease duration of 6 months or longer * Participants aged between 50 and 70 * Being able to walk without using assistive devices * Body mass index is below 35 kg/m² * Pain intensity must be between 3 and 7 according to the Numerical Pain Rating Scale * Not having received physiotherapy in the last year. Exclusion Criteria: * Infiltration with steroids or local anesthetics in the year before the patient entered the study or during follow-up * Obtaining the indication for surgery * Severe hearing, vision and speech impairment * Having serious systemic and cardiovascular diseases that prevent exercise * Having a neurological disease * Having a lower extremity deformity (severe varus or valgus deformity, significant joint instability and other orthopedic problems requiring surgical intervention) * Patients with acute knee inflammation * Having any disorder, syndrome or disease that may cause myofascial or neuropathic pain in the lower extremities, such as lumbar radiculopathy, meralgia paresthetica or Saphenous nerve compression. * Cognitive deficit (Alzheimer's, dementia) revealed in the clinical history.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Istinye University
Istanbul, Istanbul, 34010, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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