MOVEMENT DISORDERS

This study follows 1,000 people with Parkinson's disease, essential tremor, or dystonia who receive an Abbott deep brain stimulation (DBS) system. Researchers will measure changes in movement symptoms and track any serious side effects over five years. The goal is to confirm the …

This study is a registry that will follow 60 people with advanced Parkinson's disease who are receiving a treatment called Exablate. The treatment uses focused ultrasound to target a small area in the brain to help control movement problems that medication no longer manages well.…

This study uses botulinum toxin (Botox) injections to treat movement disorders like dystonia, tremors, and spasms. It aims to improve symptoms and train doctors in injection techniques. Up to 2000 people aged 2 and older with these conditions can join. Treatment is ongoing and do…

This study looks at two different exercise routines for veterans with moderate Parkinson's disease. One group exercises a lot for one week, then rests for three weeks. The other group exercises every week without breaks. Researchers will measure walking speed, overall physical ac…

This study tests whether eight weeks of mindfulness training can improve emotional well-being and strengthen the relationship between people with Parkinson's disease and their family caregivers. About 200 Chinese patient-caregiver pairs will be randomly assigned to either the min…

This study tests a non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can reduce tremors and improve walking in people with Parkinson's disease. Researchers will compare real stimulation to a sham (fake) stimulation in 50 adults a…

This study is testing a portable, wearable exoskeleton that can stretch the legs and assist with walking for people who have muscle stiffness (spasticity) due to a spinal cord injury. Ten veterans will try the device during leg stretches, treadmill walking, and overground walking…

This study gathers information from 500 children worldwide who have both epilepsy and movement disorders. Researchers will review medical records and genetic data to find patterns linking these conditions. The goal is to better understand these rare diseases and guide more person…

This study aims to better understand the brain activity behind movement disorders like Parkinson's disease, essential tremor, dystonia, and ataxia. Researchers will record electrical signals from the brain using scalp electrodes or through existing deep brain stimulation devices.…

This study is creating a shared database of information from up to 100 children who have had or will have deep brain stimulation (DBS) for conditions like dystonia, epilepsy, or Tourette syndrome. By combining data from multiple hospitals, researchers hope to learn which children…

This study aims to develop algorithms that can help people with paralysis move again using assistive devices like robotic arms or wheelchairs. Researchers will record brain and muscle signals from 50 healthy volunteers as they perform, imagine, or attempt movements. The goal is t…

This study is creating a large collection of blood, spinal fluid, and urine samples from 800 people with ALS and 200 healthy volunteers. Researchers will also track symptoms and physical function over time. The goal is to provide this data to scientists worldwide to help them bet…

This study explores whether a brain-computer interface (BCI) can help people with motor disorders, like spinal cord injury or stroke, control assistive devices just by thinking about moving. Researchers will use electrical stimulation to train the brain and improve BCI accuracy. …

This study is collecting information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are scheduled to receive a standard radiofrequency (RF) ablation treatment. The goal is to see how the procedure affects patients' quality of…

This study aims to see if a new computer algorithm can accurately measure how many calories people with movement limitations burn each day. Researchers will compare readings from a wearable accelerometer against a precise water-based test. The study involves 125 adults who can wa…

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare nerve diseases that cause progressive muscle stiffness and disability. Researchers will analyze DNA from 200 children and adults with HSP to find gene variants linked to the cond…

This study looks at brain activity in people with Parkinson's disease or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to understand how the brain handles both movement problems and non-motor issues like memory or mood chang…