Zapping the brain to steady Parkinson's tremors and steps
NCT ID NCT07384442
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation can improve tremor and walking difficulties in people with Parkinson's disease. Fifty participants will be randomly assigned to receive either real or sham stimulation daily for 19 days. Researchers will measure changes in tremor intensity and gait quality using specialized devices.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- temporal interference stimulation (a non-invasive brain stimulation device)
- What this could lead to
- If it works, this could offer a new, non-drug way to reduce tremor and improve walking in people with Parkinson's disease.
- What could go wrong
- This is an early-stage trial with only 50 people, so results may not apply to everyone. The stimulation is non-invasive, but it may not work better than a sham (placebo) treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1.Aged 50 years or older; * 2.Confirmed diagnosis of idiopathic Parkinson's disease (IPD) according to the 2015 MDS diagnostic criteria, with tremor and gait disturbance; * 3.Disease duration ≥2 years after diagnosis, stable condition, and ability to cooperate with study assessment and intervention; * 4.Stable medication dosage for at least 4 weeks prior to the trial; * 5.Good response to Levodopa therapy; * 6.Capable of independent walking (without assistive devices) for at least 5 minutes and able to complete gait testing independently. * 7.Signed informed consent form, with the participant or their legal guardian able to understand and willing to participate in this study. Exclusion Criteria: * 1.History or confirmed diagnosis of severe mental disorders, such as depression, anxiety disorders, schizophrenia spectrum disorders, and bipolar disorder; * 2.The subject has clinically defined neurological conditions (assessed through self-report), including but not limited to: any disease potentially associated with increased intracranial pressure, space-occupying lesions, stroke history, transient ischemic attack (TIA) within the past two years, cerebral aneurysm, dementia, multiple sclerosis; * 3.Severe cognitive impairment, Mini-Mental State Examination (MMSE) score \<22, or inability to independently complete questionnaires; * 4.Inability to read or understand Chinese; * 5.Use of other neuromodulatory therapies within the past 3 months; * 6.Presence of musculoskeletal or orthopedic conditions (e.g., severe arthritis, recent fractures) that significantly interfere with gait or balance; * 7.Presence of metal implants (e.g., Deep Brain Stimulation, cardiac pacemakers) or contraindications for MRI/TIS; * 8.Current use of medications that affect dopamine levels (e.g., antipsychotics); * 9.Severe cardiovascular disease or other unstable medical conditions that preclude physical exertion or study participation;
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Zhongnan hospital
Wuhan, Hubei, 430000, China
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Other studies related to the condition(s) this trial covers.
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