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Shake it off: vibration therapy may boost bone health after knee surgery

NCT ID NCT06988033

Disease control Sponsor: Istinye University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests whether whole-body vibration therapy, alone or combined with exercise, can improve bone health and physical function in women with low bone density who have had a total knee replacement. Forty-eight women will be randomly assigned to vibration only, vibration plus exercise, or standard rehab. Researchers will measure bone turnover markers, mobility, strength, and pain over 12 weeks after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Whole-body vibration therapy
What this could lead to
If it works, this could point toward a simple, drug-free way to help women regain strength and protect bone after knee replacement.
What could go wrong
This is a small, early-stage trial with only 48 participants. The vibration protocols are experimental, and results may not apply to all patients. There is also a risk that adding vibration does not improve outcomes over standard rehab.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

48 people

The number who actually took part.

Started

Aug 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 75 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled to undergo unilateral, primary, cemented total knee arthroplasty (TKA) using a posterior cruciate ligament-sacrificing technique and medial parapatellar approach due to knee osteoarthritis * Ability to speak and understand Turkish * Ability to comprehend both verbal and written information * A T-score between -2.5 and -1 (i.e., -2.5 \< T-score \< -1) measured by DXA in the lumbar spine, total hip, or femoral neck within the past year Exclusion Criteria: * Scheduled for revision TKA * American Society of Anesthesiologists (ASA) physical status classification score higher than 3 * History of major surgery on the limb to be operated * Presence of comorbid diseases such as rheumatoid arthritis or cancer * Presence of a neurological condition causing functional impairment * Diagnosed psychiatric disorder * Dementia * Disorders affecting the vestibular system * Having undergone anesthesia for any reason within the last month * Regular use of hypnotic or anxiolytic medications * Hearing or vision impairment not correctable by hearing aids or glasses * Presence of endocrine system disorders * Secondary osteoporosis or history of osteoporotic fracture * Metabolic bone diseases or chronic illnesses potentially affecting bone metabolism * Use of medications known to affect bone metabolism (e.g., menopausal hormone therapy, bisphosphonates, raloxifene, calcitonin, growth hormone, parathyroid hormones, corticosteroids) within 6 months prior to the start of the study

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Conditions

The condition(s) this trial relates to.

Bone Diseases, Metabolic osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteopenia Total knee arthroplasty

Contacts and locations

Locations

  • Sultan 2. Abdulhamid Han Training and Research Hospital

    Istanbul, Uskudar, 34668, Turkey (Türkiye)

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