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Beads that block blood flow could ease knee arthritis pain

NCT ID NCT05112926

Symptom relief Sponsor: University of Miami Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study tests whether injecting tiny beads into arteries around the knee can reduce pain in people with moderate to severe knee osteoarthritis. The beads block blood flow to the painful area. Nine adults aged 40 to 80 who have not gotten relief from standard treatments are taking part. Researchers will measure pain changes and watch for side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Embosphere Microspheres (tiny beads used to block blood flow)
What this could lead to
If it works, this could offer a new way to reduce knee pain without surgery or long-term medication.
What could go wrong
This is a very small, early study with only 9 people, so results may not apply widely. The procedure carries risks like pain, swelling, or damage to nearby tissue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

9 people

The number who actually took part.

Started

Dec 2022

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subject has signed informed consent * Subject is age 40-80 * Subject is able to have an MRI * Minimum of prior 12 weeks of failed response to conservative therapy for knee osteoarthritis, which may include one or more of: a) Oral or topical NSAIDS, opioid medications, intra-articular injection of glucocorticoids or hyaluronic acid, physical therapy. * Localized tenderness in anterior knee area * Kellgren-Lawrence grade 1, 2, or 3 as assessed by weight-bearing knee radiographs * Synovitis present as assessed by WORMS * VAS \>50 mm * WOMAC score \>30 Exclusion Criteria: * Rheumatoid arthritis * Local infection of the target knee(s) * Kellgren-Lawrence grade \>3 * Osteonecrosis evident by MRI * Prior knee arthroplasty * Allergy to iodinated contrast agents that cannot be managed by prophylaxis * Hypersensitivity to gelatin products * Any known condition that limits catheter-based intervention or is a contraindication to embolization * Active malignancy other than non-melanomatous skin cancer * Subject is pregnant, breastfeeding, or pre-menopausal and intending to become pregnant * Any other condition related to the subject's health and wellbeing deemed exclusionary in the opinion of the investigator

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • University of Miami

    Miami, Florida, 33136, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.