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New therapy may ease knee pain without surgery

NCT ID NCT05801510

Symptom relief Sponsor: University of Salford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested Cognitive Muscular Therapy (CMT) for people with knee osteoarthritis waiting for joint replacement. CMT uses biofeedback to reduce muscle overactivity and improve posture, helping people change how they react to pain. The goal was to see if it could provide pain relief during the wait for surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cognitive Muscular Therapy (a type of physiotherapy with biofeedback)
What this could lead to
If it works, this could provide a way to manage knee pain without surgery while people wait for joint replacement.
What could go wrong
This was a small, early study with only 36 people, so results may not apply to everyone. The therapy is behavioral, so it may not work for all types of knee pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Mar 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion: 1. Above 40 years old 2. Speak and understand English sufficient to read the information sheet and sign the consent form 3. Ability to walk without any assistive device for at 20m (to ensure sufficient mobility to complete the intervention) 4. Radiological diagnosis of knee OA 5. On orthopaedic waiting but currently expected to wait at least 6 months for surgery (this will ensure that that the patient's care pathway is not affected) Exclusion: 1. Dementia or other major cognitive impairment. 2. BMI \>30 (as increased subcutaneous fat prevents collection of surface EMG signals) 3. Previous knee replacement 4. Any active systemic inflammatory disorders, such as rheumatoid arthritis with patient taking immunosuppressant drugs or steroids 5. Any balance disorders which may increase the risk of a fall 6. A history of rupture to the anterior cruciate ligament/ posterior cruciate ligament/ medial collateral ligament/ lateral collateral ligament 7. A diagnosis of psoriatic arthritis 8. A diagnosis of post traumatic arthritis for example after a previous tibial plateau/ patella fracture 9. A diagnosis of septic arthritis

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • University of Salford

    Manchester, Greater Manchester, M6 6PU, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.