Knee replacement patients get extra pain relief from bone injection of morphine?
NCT ID NCT06716749
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether adding morphine to a standard antibiotic injection into the shin bone during knee replacement surgery reduces pain afterward. About 100 adults having their first knee replacement took part. Half got morphine with the antibiotic, half got a placebo. Researchers measured pain scores and how much pain medication patients needed after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Morphine
- What this could lead to
- If it works, this could offer a simple way to reduce pain after knee replacement without extra pills.
- What could go wrong
- This is a small, early-phase study. The benefit may be small or not apply to all patients, and morphine can cause nausea or vomiting.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
100 people
The number who actually took part.
- Started
-
Dec 2024
- Finished
-
Jun 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 100 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. 18-100 years old 2. Primary total knee arthroplasty 3. Participants must be able to consent for themselves 4. Capable and comfortable with text messaging Exclusion Criteria: 1. Non-primary total knee arthroplasty 2. Intraoperative or postoperative deviation from standard of care 3. Post-traumatic surgical indication 4. Post-infectious surgical indication 5. Chronic narcotic use or history of narcotic addiction 6. Allergy to vancomycin 7. Allergy to morphine 8. Inability to receive spinal anesthesia 9. Inability to receive intraoperative adductor canal block 10. Inability to provide informed consent for the study 11. Inability to speak English fluently
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Intraosseous morphine injection are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Carilion Clinic
Roanoke, Virginia, 24014, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Custom knee guides put to the test in obese patients
- Can a shot of your own blood ease arthritic knees?
- 5,000 knee arthritis patients tracked to crack the treatment code
- Can a hydrogel injection ease knee arthritis pain?
- Weekly shot aims to melt away pounds in obesity fight
- Can shockwave plus injections quiet knee arthritis pain?