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Knee pain relief showdown: Hyruan-One vs. synvisc in new study

NCT ID NCT03484091

Symptom relief Sponsor: Thammasat University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a single injection of Hyruan-One works better than Synvisc or a saline placebo for knee osteoarthritis pain. 276 adults with knee osteoarthritis who had not gotten relief from other treatments took part. The main goal was to measure pain changes over 6 months using a standard pain scale.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyaluronic acid (Hyruan-One and Hylan G-F 20/Synvisc)
What this could lead to
If it works, this could confirm that a single injection of Hyruan-One provides similar or better pain relief for knee osteoarthritis compared to an existing treatment.
What could go wrong
This is a completed Phase 4 trial, but results may not apply to all patients. The effect is temporary symptom relief, not a cure, and some people may not benefit or may have side effects like injection-site pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

276 people

The number who actually took part.

Started

Apr 2018

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Symptomatic primary knee osteoarthritis with failed conservative treatment for at least 3 months * Gave informed consent * Can do questionnaires Exclusion Criteria: * Severe deformity (varus or valgus from a mechanical axis more than 10 degrees * Allergy to hyaluronic acid * Pain in the hip or ankle * Post-traumatic or post surgery of lower extremity * Post-infection of the knee * Previous hyaluronic acid injection within 6 months * Pregnancy or lactation * Underlying Rheumatoid arthritis, stroke, malignancy, venous occlusion

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • Thammasat University

    Khlong Luang, Changwat Pathum Thani, 12120, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.