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Shock and serenity: new combo therapy targets knee pain without pills

NCT ID NCT04375072

Symptom relief Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a two-week home treatment combining gentle brain stimulation (tDCS) with mindfulness meditation in 208 older adults with knee osteoarthritis. The goal was to see if this drug-free approach could reduce pain and improve daily function. Results focused on changes in pain scores and joint stiffness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

208 people

The number who actually took part.

Started

Aug 2020

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * have symptomatic knee OA based on American College of Rheumatology clinical criteria * have had knee OA pain in the past 3 months with an average of at least 30 on a 0-100 NRS for pain, * can speak and read English * have no plan to change medication regimens for pain throughout the trial Exclusion Criteria: * history of brain surgery, brain tumor, seizure, stroke, or intracranial metal implantation * systemic rheumatic disorders, including rheumatoid arthritis,systemic lupus erythematosus, and fibromyalgia * alcohol/substance abuse * diminished cognitive function that would interfere with understanding study procedures (i.e., Mini-Mental Status Exam score ≤ 23) * pregnancy or lactation * prosthetic knee replacement or non-arthroscopic surgery to the affected knee * hospitalization within the preceding year for psychiatric illness * no access to a device that can be used for secure videoconferencing for real-time remote supervision.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteo arthritis knee

Contacts and locations

Locations

  • University of Arizona

    Tucson, Arizona, 85721, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.