KNEE OSTEOARTHRITIS

This study looks at whether walking to music or a metronome can help reduce pain and change how muscles work in people with chronic knee osteoarthritis. About 20 adults with knee pain will try three different walking conditions: with music, with a metronome, and without any sound…

This study compares two hands-on physical therapy techniques—Mulligan's mobilization with movement and Kaltenborn's sustained mobilization—both combined with eccentric exercises, to see which better reduces pain and improves daily function in people with knee osteoarthritis. Sixt…

This study tests whether tiny gold particles injected into the knee can reduce pain and the need for extra treatments in people with knee osteoarthritis. About 240 adults with long-term knee pain will receive either the gold injection or a placebo. The goal is to see if this simp…

This study compares two ways to do a total knee replacement: mechanical alignment (straightening the leg) and kinematic alignment (keeping the leg's natural angle). The goal is to see which method leads to less pain and better function after surgery. About 96 adults with knee ost…

This study will compare two types of total knee replacement surgery for people with knee osteoarthritis: one using a robotic device (VELYS) and the other done by hand. About 346 participants will be randomly assigned to one of the two methods. The goal is to see if the robotic ap…

This study compares three types of knee injections—steroids, dextrose prolotherapy, and platelet-rich plasma (PRP)—to see which provides the best pain relief for people with knee osteoarthritis. Researchers will enroll 72 adults aged 40 to 80 who have had knee pain for at least s…

This study tests whether a paste made from ejiao (donkey-hide gelatin) can ease knee pain in people with osteoarthritis who also have a pattern called Qi and Blood Deficiency. About 60 adults aged 40 to 75 will use the paste or a dummy paste for 12 weeks. The main goal is to see …

This study tests whether healthy lifestyle education and personalized physical activity counseling can reduce pain, improve physical function, and help people with knee osteoarthritis stick to exercise. About 26 adults aged 40 and older with knee osteoarthritis will be randomly a…

This study compares two methods to control pain after total knee replacement: a long-acting painkiller (Zynrelef) injected into the knee during surgery versus a standard nerve block. The goal is to see which approach reduces the need for opioid painkillers in the first 72 hours a…

This study tests whether applying bee venom gel to the skin with ultrasound (phonophoresis) can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40 to 75 with moderate to severe knee pain will receive either the bee venom treatment or a plac…

This study tests whether a surgeon can give a pain-relieving nerve block during knee replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one type of block on each knee. The goal is to see if the surgeon's metho…

This early-stage study tests whether an injection called NANOVAE, made from donated amniotic fluid, can safely reduce pain and improve function in people with knee osteoarthritis. About 24 adults aged 21–75 with moderate knee arthritis will receive either the injection or a place…

This study compares two types of steroid injections added to standard pain control during total knee replacement. The goal is to see which option reduces pain, limits opioid use, and improves knee movement. About 240 adults with severe knee arthritis will be randomly assigned to …

This study looks at whether a special two-bar knee brace, combined with exercises that don't put weight on the knee, can reduce pain and stiffness better than a standard brace in people with knee osteoarthritis. 18 adults aged 45-60 with moderate knee arthritis will be randomly a…

This study looks at whether a special gel containing etodolac, applied to the skin, can improve pain and function in people with knee osteoarthritis when used alongside standard physiotherapy. Thirty adults aged 45-60 with mild to moderate knee OA will be randomly assigned to rec…

This study compares two types of physical therapy—one in water and one on land—to see which better reduces pain and improves daily function in people with knee osteoarthritis. Researchers will enroll 66 adults aged 40 to 65 who have had knee osteoarthritis for at least a year. Pa…

This study tests whether inulin, a type of dietary fiber, can reduce inflammation and knee pain in older adults with osteoarthritis. About 84 participants will take either inulin or a placebo for 8 weeks. Researchers will measure changes in blood markers of inflammation and self-…

This study tests if using a heart rate monitor to personalize home exercise can reduce pain and improve daily function in people with knee osteoarthritis. 240 adults aged 45 and older will either follow a standard exercise program or one that adjusts intensity based on their dail…

This study tests whether adding trunk stabilization exercises to standard physical therapy can reduce knee pain and improve daily function in people with knee osteoarthritis who also have back pain (knee-spine syndrome). About 70 adults aged 40-60 with moderate knee arthritis wil…

This study looks at whether making small holes in a Baker's cyst (a fluid-filled lump behind the knee) during a standard drainage procedure can reduce pain and prevent the cyst from coming back. About 44 adults with knee osteoarthritis and a Baker's cyst will be randomly assigned…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises as effectively as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receiving standard in-person sessions, the other …

This study looks at two different ways to help overweight women with knee osteoarthritis feel better and move easier. One method uses a special treadmill that takes weight off the knees, while the other uses dietary supplements (alpha lipoic acid and omega-3s). The goal is to see…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get standard education, a…

This study tests whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. Researchers will enroll 52 adults aged 40-60 with moderate knee arthritis. Participants will be split into t…

This study looks at whether a procedure to fix varicose veins can also reduce knee pain in people aged 80 and older. Researchers will treat 50 participants with endovenous ablation and track their pain and knee function for a year. The goal is to see if improving blood flow in th…

This study looks at whether adding an iPACK nerve block to a standard adductor canal block can lower the body's inflammatory response and improve pain control after hip replacement surgery. It involves 60 older adults (ages 65-100) who are scheduled for hip replacement under spin…

This study looks at whether doing your own exercise at a local fitness center works as well as supervised sessions with a physiotherapist for knee osteoarthritis. About 300 adults aged 45 and older with knee pain will be assigned to either self-managed gym workouts or standard ph…

This study will follow 99 adults aged 50 to 80 who are having knee replacement surgery. It aims to see if giving the steroid dexamethasone (by mouth or IV) around the time of surgery helps reduce pain, improve mobility, and lessen nausea compared to not giving it. The drug is giv…

This study compares two physical therapy approaches for people with knee osteoarthritis: a positional release technique targeting specific leg muscles versus exercises to improve balance and joint awareness. The goal is to see which method better reduces pain, stiffness, and disa…

This study looks back at medical records from 3,500 adults who had a first-time knee replacement to compare different implant brands. The goal is to see which ones work best over the medium and long term in terms of knee function, safety, and cost. Results will help surgeons and …

This study looks at whether two proteins in the blood, called COMP and MMP-3, are linked to the severity of knee osteoarthritis. Researchers will measure these proteins in 60 people with and without knee arthritis and compare them to pain, function, and X-ray findings. The goal i…

This study follows 50 adults with varicose veins and knee pain to see if standard vein treatment also improves knee symptoms. Participants receive usual care (radiofrequency or laser ablation) and report changes in pain and function over time. The goal is to learn whether fixing …

This study looks at how lipedema, a condition where fat builds up in the legs, affects knee osteoarthritis. Researchers will compare 76 women with knee arthritis—some with lipedema and some without—using ultrasound to measure cartilage thickness and questionnaires to assess pain …

This study will use advanced PET/MRI scans to look at changes in knee metabolism after a procedure called genicular artery embolization (GAE) for knee osteoarthritis. The goal is to understand why some patients get significant pain relief while others do not. Researchers will enr…