KNEE OSTEOARTHRITIS

This study is testing whether injecting tiny gold particles into the knee joint can help people with knee osteoarthritis. Researchers want to see if this treatment reduces pain and delays the need for additional treatments like injections or surgery over one year. The trial will …

This study is testing whether a gentle, non-invasive brain stimulation technique can reduce pain and improve daily function for people with knee osteoarthritis. Researchers will compare real stimulation to a placebo in 102 participants over three weeks. The goal is to see if this…

This study is testing whether adding a topical anti-inflammatory gel to standard physical therapy provides better relief for knee osteoarthritis. Thirty adults aged 45-60 with mild to moderate knee arthritis will receive either physical therapy alone or physical therapy plus the …

This study aims to find the best way to set up group physical therapy programs for Veterans with knee osteoarthritis. Researchers will compare two different implementation approaches across 20 VA facilities to see which helps more Veterans access care. The goal is to improve pain…

This study compares two ways to give pain-blocking injections during double knee replacement surgery. Patients will receive one type of injection from their surgeon on one knee and a different type from an anesthesiologist on the other knee. Researchers want to see if the surgeon…

This study aims to see if self-managed exercise at a local fitness center works as well as supervised physical therapy for reducing knee osteoarthritis pain and improving function. Researchers will compare these two approaches in 300 adults with knee arthritis to determine which …

This study will compare two types of physical therapy for people with knee osteoarthritis: one done in a pool (aquatic) and one done on land. Researchers want to see if exercising in water helps reduce pain and improve daily movement more effectively than similar exercises on sol…

This study is testing if a specific combination of nerve blocks can better control pain and reduce the body's inflammatory response after hip replacement surgery. It will involve 60 elderly patients undergoing the procedure. Researchers will compare the real nerve blocks to a sha…

This study aims to see which of two common injection treatments works better for reducing pain and improving movement in people with knee osteoarthritis. Doctors will follow 86 adult patients for six months after they receive either a dextrose (sugar water) injection or a standar…

This study is testing whether an AI-powered smartphone app can help people with knee osteoarthritis manage their pain as effectively as seeing a physiotherapist in person. Researchers will compare three groups: one using only the app, one having only in-person sessions, and one u…

This study is testing whether using ultrasound to deliver bee venom through the skin can help manage pain and improve mobility in people with knee osteoarthritis. Thirty adults with knee arthritis will be randomly assigned to receive either the bee venom treatment or a placebo ge…

This study aims to find the best pain-control injection for adults having total knee replacement surgery. Researchers will compare a standard pain injection to the same injection with two different steroids added. The goal is to see which option best reduces pain, limits opioid m…

This study aims to see if specific exercise programs can help people with knee osteoarthritis feel less pain and move more easily. Researchers will compare a supervised exercise program, a home-based program, and usual care over 12 weeks. The goal is to find the best way to help …

This study aims to find out which of two physical therapy approaches works better for people with moderate knee osteoarthritis. Researchers will compare two different hands-on joint mobilization techniques, both combined with special strengthening exercises, in 68 participants. T…

This study aims to find out which of three common knee injections works best for long-term pain relief in people with knee osteoarthritis. It will directly compare steroid shots, dextrose prolotherapy, and platelet-rich plasma (PRP) injections in 72 patients. The goal is to see w…

This study is testing whether a smartphone app that uses artificial intelligence (AI) to guide home exercises works better than standard paper instructions for reducing pain and improving function in people with knee osteoarthritis. About 84 adults with knee pain will be randomly…

This study is testing if adding a small extra step to a common knee cyst treatment works better. The treatment drains a painful fluid-filled cyst behind the knee and injects medication. The extra step, called fenestration, involves making tiny holes in the cyst wall to help it dr…

This study aims to find which approach works better for overweight women with knee osteoarthritis: using a special treadmill that reduces body weight pressure during walking, or taking a combination of two dietary supplements. Researchers will compare how much each method reduces…

This study is testing whether adding trunk (core) stabilization exercises to standard physical therapy helps people with both knee osteoarthritis and back pain. It will involve 70 adults aged 40-60. The goal is to see if improving core strength can reduce knee pain and make daily…

This study will compare two different surgical approaches for total knee replacement in patients with severe arthritis. Researchers want to see if one method leads to better pain relief, improved knee function, and higher patient satisfaction after surgery. Participants will be r…

This study aims to see which of two physical therapy methods works better for people with knee osteoarthritis. Researchers will compare a hands-on manual therapy technique with specific balance and coordination exercises. The goal is to find out which approach is more effective a…

This study is testing a new way to guide home exercises for people with knee osteoarthritis. It uses a smartphone app that measures daily heart rate patterns to personalize exercise intensity, aiming to reduce pain and improve function better than a standard exercise program. Res…

This study will observe 50 adults with varicose veins and knee pain to see if standard vein treatment improves their knee discomfort and function. Participants will receive their planned vein procedure and be followed for changes in pain, mobility, and quality of life. The resear…

This study compares two different approaches to managing pain after knee replacement surgery. Researchers want to see whether a long-acting numbing medication injected around the knee joint works better than a nerve block in the thigh at reducing the need for opioid painkillers. …

This study is testing whether a daily fiber supplement called inulin can reduce knee pain and inflammation in older adults with osteoarthritis. For 8 weeks, 84 participants will take either inulin or a placebo powder to see if it improves gut health and lowers a blood marker link…

This study is testing whether taking collagen peptide supplements before and after total knee replacement surgery helps the body heal better. Researchers will enroll 44 adults aged 50-75 with knee osteoarthritis who are scheduled for the surgery. They will compare outcomes like w…

This study will test whether a specific leg muscle strengthening program can help people with knee osteoarthritis walk better, feel less pain, and sleep more soundly. It will involve 52 adults aged 40-60 with moderate knee arthritis. Participants will be randomly assigned to eith…

This study aims to see if the way a common steroid (dexamethasone) is given—by mouth or through an IV—affects pain and recovery right after knee replacement surgery. It will observe 99 patients who are already scheduled for surgery, following their normal doctor's plan without ch…

This study is investigating whether a minimally invasive procedure to treat varicose veins can also relieve knee pain in people aged 80 and older. Researchers will follow 50 elderly patients who have both varicose veins and knee pain for one year after they receive the standard v…

This study aims to create a new scoring system to predict how satisfied patients will be after knee replacement surgery. Researchers will use a smartphone app to collect long-term movement data and survey responses from 450 patients before and after their procedure. The goal is t…

This study aims to understand the link between knee pain and the physical structure of the kneecap joint. Researchers will use special weight-bearing CT scans on 36 adults with knee pain from conditions like osteoarthritis or 'runner's knee'. The goal is to see if specific measur…