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Can nerve stimulation plus exercise ease knee pain in seniors?

NCT ID NCT07258693

Symptom relief Sponsor: University of Jaén Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study tests whether adding a type of nerve stimulation (NESA or TENS) to a supervised exercise program can better reduce pain, improve function, and boost mental health in people over 60 with knee osteoarthritis. Over 8 weeks, 110 participants will receive either exercise plus NESA or exercise plus TENS. Researchers will measure pain, mobility, strength, sleep, and mood to see which combination works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
therapeutic exercise combined with noninvasive neuromodulation (NESA) or transcutaneous electrical nerve stimulation (TENS)
What this could lead to
If this works, it could point toward a more effective, drug-free way to reduce pain and improve mobility and mental health for older adults with knee osteoarthritis.
What could go wrong
This is a small, early-stage study with no blinding, so results may be influenced by participant expectations. The treatments are noninvasive and low-risk, but the added benefit of NESA over TENS is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

110 people

The number who actually took part.

Started

Jan 2026

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals over 60 years of age. * Diagnosis of knee osteoarthritis in at least one knee according to the clinical criteria of the American College of Rheumatology. * Ability to walk independently without the need for assistive devices. * No medical contraindications to physical exercise or the application of noninvasive neuromodulation (NESA). * Ability to understand and sign the informed consent form to participate in the study. Exclusion Criteria: * Present medical contraindications to physical exercise or the application of noninvasive neuromodulation (NSA) (pacemaker, epilepsy, internal bleeding, acute febrile processes, acute thrombophlebitis, and/or phobia of electricity). * Present active oncological diseases or systemic autoimmune diseases. * Present severe psychiatric or neurological disorders that limit understanding and collaboration in treatment. * History of any surgery or fracture of the affected lower limb in the last 3 months. * Presence of severe gait or balance difficulties that impede the performance of the proposed exercises. * Simultaneous participation in other clinical trials.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteo arthritis knee

Contacts and locations

Locations

  • ICOT rehabilitation centers

    Las Palmas de Gran Canaria, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.