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Could ozone be the key to easing knee arthritis pain?

NCT ID NCT07678996

Symptom relief Sponsor: Kayseri City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests whether injecting ozone gas into the knee joint, combined with exercise, can reduce pain and improve function in people aged 40-75 with moderate knee osteoarthritis. Participants receive three weekly ozone injections at different concentrations (10, 15, or 20 µg/mL) plus a home exercise program, or exercise alone. The goal is to find the most effective dose for symptom relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone
What this could lead to
If effective, ozone injections could offer a non-surgical option to reduce pain and improve mobility in people with knee osteoarthritis.
What could go wrong
This is a small, early-stage trial with 80 participants, so results may not apply widely. Ozone injections may cause discomfort or infection, and the benefit over exercise alone is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 40-75 years diagnosed with knee osteoarthritis according to the American College of Rheumatology 2019 criteria * Grade 2 or 3 knee osteoarthritis based on the Kellgren-Lawrence radiological classification system. * Presence of chronic knee pain lasting for more than 6 months. * Numerical Rating Scale score of 3 or higher during knee-loading activities Exclusion Criteria: * Presence or history of acute knee infection, major knee trauma, or inflammatory arthritis * History of knee fracture or surgical intervention involving the affected knee joint within the last 6 months. * History of intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) into the affected knee joint within the last 6 months. * History of physical therapy or rehabilitation in the knee region within the last 6 months * Presence of osteomyelitis adjacent to the knee joint, bacteremia, or hemarthrosis. * History of malignancy involving the lower extremity. * Known hypersensitivity or allergy to medical ozone. * Severe anemia, thrombocytopenia, active bleeding disorders, or ongoing anticoagulant therapy. * Pregnancy or lactation * Active infection * Severe systemic diseases (e.g., advanced cardiopulmonary disease, uncontrolled diabetes mellitus). * Hyperthyroidism or progressive neuromuscular disorders. * Cognitive impairment or inability to cooperate with the assessment tools and study protocol.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kayseri City Hospital

    RECRUITING

    Kayseri, 38080, Turkey (Türkiye)

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