Can a home workout program help you move better after knee replacement?
NCT ID NCT06768762
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at which extra features added to an online exercise program help people who have had a knee replacement become more active. About 336 adults who had knee surgery at least a year ago and currently do little exercise will take part. Researchers will track changes in physical activity, pain, and function over 6 to 12 months to find the best approach.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 336 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Jul 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * had a knee replacement (including primary, staged or independent bilateral, or revision) at least 12 months ago * have a computer, tablet, or smartphone with active internet access * self-report engaging in less than 60 minutes/week of moderate-intensity physical activity * be English-speaking and able to read consent and study materials written in English * be willing to complete the 4 remote assessments, including physical activity monitoring * be willing to be randomized to receive 0-4 supplemental intervention components. Exclusion Criteria: * any contraindications to physical activity (e.g., chest pain) * have a scheduled surgery within the next 12 months (e.g., hip or knee replacement) * have a mobility limiting comorbidity unrelated to knee replacement * live outside of the continental U.S * do not currently have a physician or orthopedic surgeon whom they see regularly * are currently participating in physical therapy (for knee) * are participating in a structured weight loss or physical activity program * unable to provide proof of knee replacement surgery * have a BMI \>40kg/m2 * score \>30 on PROMIS cognitive function
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of South Carolina
RECRUITINGColumbia, South Carolina, 29208, United States
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