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10,000 knee pain patients enrolled in massive treatment registry

NCT ID NCT05495334

Knowledge-focused Sponsor: Pacira Pharmaceuticals, Inc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This registry will follow 10,000 people receiving various pain treatments for knee osteoarthritis, such as injections, nerve blocks, or knee replacement. Researchers will track pain levels, function, sleep, and side effects over time. The goal is to learn which approaches work best in everyday medical practice.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this registry could help doctors understand which pain treatments work best for knee osteoarthritis in real-world settings.
What could go wrong
This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by patient differences and treatment choices.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2021

Expected to finish

Dec 2033

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients who are planned to receive treatment within 60 days of screening for knee OA pain will be screened, and if eligible, will be approached for participation in the registry.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Planned to receive treatment for knee OA pain including, but not limited to, knee injections, nerve blocking procedures, or knee arthroplasty within 60 days of screening 2. Able to understand the informed consent and assessment questionnaires and have the ability to complete them in the opinion of the investigator 3. Have access to a smartphone or internet access with a computer/tablet to complete the questionnaires using the registry application Exclusion Criteria: 1. Actively enrolled in an investigational trial that would preclude patients from receiving the site's standard of care for knee OA pain or knee arthroplasty recovery protocol 2. Planning to have a surgery other than on the target knee

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    15 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Blue Nine Systems

    TERMINATED

    Asheville, North Carolina, 28801, United States

  • Campbell Clinic

    RECRUITING

    Germantown, Tennessee, 38138, United States

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • Florida Orthopaedic Associates

    RECRUITING

    DeLand, Florida, 32720, United States

  • Genesee Orthopedics and Plastic Surgery (St. Elizabeth Med Center/ Apex Surgical Center)

    COMPLETED

    New Hartford, New York, 13413, United States

  • Henry M Jackson Foundation for the Advancement of Military Medicine/Walter Reed National Military Medical Center

    TERMINATED

    Bethesda, Maryland, 20889, United States

  • Jersey City Medical Center

    TERMINATED

    Jersey City, New Jersey, 07302, United States

  • Louisiana State University /Ochsner

    RECRUITING

    New Orleans, Louisiana, 70112, United States

  • MidState Orthopedics and Sports Medicine

    RECRUITING

    Alexandria, Louisiana, 71301, United States

  • Northwell Health

    RECRUITING

    Garden City, New York, 11530, United States

  • Oklahoma Surgical Hospital

    RECRUITING

    Tulsa, Oklahoma, 74137, United States

  • OrthoNebraska Clinics

    RECRUITING

    Omaha, Nebraska, 68144, United States

  • Orthopaedic Surgical Associates

    RECRUITING

    North Chelmsford, Massachusetts, 01863, United States

  • Orthopedic Education and Research Institute of So Ca (Hoag)

    RECRUITING

    Irvine, California, 92618, United States

  • Penn Highlands DuBois

    RECRUITING

    DuBois, Pennsylvania, 15824, United States

  • Sinai Hospital of Baltimore

    RECRUITING

    Baltimore, Maryland, 21215, United States

  • The MORE Foundation

    RECRUITING

    Phoenix, Arizona, 85023, United States

  • University Orthopedics Center

    RECRUITING

    State College, Pennsylvania, 16801, United States

  • University of Utah

    RECRUITING

    Salt Lake City, Utah, 84108, United States

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Other studies related to the condition(s) this trial covers.