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Can ultrasound reveal how knee ligaments change with osteoarthritis?

NCT ID NCT07744789

Knowledge-focused Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study uses a special ultrasound technique called shear wave elastography to measure the stiffness of knee ligaments in healthy adults and in people with knee osteoarthritis. The goal is to establish normal stiffness values across different ethnic groups and to see how ligament stiffness changes after clinically indicated injection therapy. Participants will undergo ultrasound exams and clinical assessments, with follow-up for those receiving injections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Shear wave elastography (ultrasound imaging) and ultrasound-guided injection therapy (corticosteroid, hypertonic dextrose, or platelet-rich plasma)
What this could lead to
If successful, this could establish normal knee ligament stiffness values across ethnicities and reveal how these change with osteoarthritis and treatment, potentially improving diagnosis and therapy monitoring.
What could go wrong
This is an observational and exploratory study, not a treatment trial. The findings may not directly change clinical practice, and the injection therapies are given based on routine care, not as part of a controlled experiment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 208 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy adult volunteers and adults with symptomatic radiographic knee osteoarthritis recruited from the outpatient Department of Physical Medicine and Rehabilitation at National Taiwan University Hospital, Bei-Hu Branch. Healthy participants are enrolled to establish normative knee ligament stiffness values, whereas patients with knee osteoarthritis undergo clinical assessment, shear wave elastography, and, when clinically indicated, follow-up evaluation after ultrasound-guided injection therapy.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Healthy volunteers: * Adults aged 20 years or older. * Able to understand the study procedures and provide written informed consent. * Able to ambulate independently without walking aids. * No pain in either knee during the previous 6 months. * Patients with symptomatic knee osteoarthritis: * Adults aged 20 years or older. * Able to understand the study procedures and provide written informed consent. * Pain in at least one knee during the previous year. * Knee pain, soreness, or stiffness documented within the previous month. * Radiographic knee osteoarthritis defined by at least one of the following: * Kellgren-Lawrence grade ≥2 on anteroposterior radiographs. * Kellgren-Lawrence grade ≥2 on skyline radiographs. * Superior or inferior patellar osteophytes or posterior tibial osteophytes on lateral radiographs. Exclusion Criteria * Healthy volunteers: * Previous knee surgery. * Rupture of any cruciate or collateral ligament. * Major knee or periarticular trauma. * Rheumatic or autoimmune disease. * Diagnosis of knee osteoarthritis within the previous 6 months. * Patients with symptomatic knee osteoarthritis: * Rheumatic or autoimmune disease. * Malignancy. * Previous major knee trauma or knee surgery. * Corticosteroid injection into the affected knee within the previous 3 months.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Taiwan University Hospital, Bei-Hu Branch

    RECRUITING

    Taipei, Taipei City, 108, Taiwan

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