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Could cutting off blood flow for minutes relieve arthritis pain?

NCT ID NCT07003113

Symptom relief Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a technique called ischemic preconditioning, where blood flow to one thigh is briefly and repeatedly restricted using a device. Over two weeks, 24 adults with knee osteoarthritis and low back pain will receive either the full treatment or a sham (low pressure) version. Researchers will measure changes in walking speed, muscle strength, and pain to see if this simple approach can improve function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ischemic preconditioning (device-based blood flow restriction)
What this could lead to
If it works, this could offer a simple, drug-free way to improve walking and reduce pain for people with knee osteoarthritis and low back pain.
What could go wrong
This is a very small early study with only 24 participants, so results may not apply widely. The procedure involves temporary blood flow restriction, which carries a small risk of blood clots or discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Reported Knee Pain using ACR Criteria * Reported Back Pain using ODI Criteria \> 12 * Ability to walk for at least 3 minutes without the use of aids * Ability to provide written informed consent Exclusion Criteria: * Younger than 50 years old * History of Knee or Hip Replacements * History of steroid injection within the previous 6 months * Presence of neuromuscular joint condition that affects lower extremity function * History of blood clots in the leg or any condition in which compression of the thigh is contraindicated * History of heart failure or thrombosis * Allergic to ultrasound gel * History of spine surgery * Non-English speaker * Currently pregnant or intends to become pregnant during the study

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Conditions

The condition(s) this trial relates to.

Back Pain Low Back Pain osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis Low back pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Human and Sport Performance Lab

    RECRUITING

    Chicago, Illinois, 60608, United States

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