University Of Illinois At Chicago

This study is testing a stem cell transplant from a partially matched family donor as a potential cure for people with severe sickle cell disease. It aims to see if the donor cells successfully take hold in the patient's body by 60 days after the transplant. The trial is for pati…

This study is testing whether an injection of donor stem cells can help heal painful, non-healing sores on the surface of the eye (corneal ulcers). It will involve 38 adults whose eye sores have not improved after at least two weeks of standard treatments. Researchers will check …

This study is testing a 12-week lifestyle program designed for Black women who are breast cancer survivors and have high blood pressure or obesity. The program provides grocery deliveries, cooking classes, and nutrition education. Researchers want to see if this approach is pract…

This study is testing whether using a special phone app with health devices and receiving personalized text messages can help people with chronic heart failure take better care of themselves. The goal is to see if these tools can help patients stay healthier at home and reduce tr…

This study is testing whether a chemotherapy regimen taken entirely as pills (cyclophosphamide, methotrexate, and capecitabine) is a safe and effective option for patients with early-stage breast cancer after surgery. The goal is to control the disease and prevent its return. Res…

This study is testing whether adding a targeted form of radiation to a stem cell transplant helps kill more cancer cells in the bone marrow and lowers the chance of the disease coming back. Adults (18-75) with acute leukemia or myelodysplastic syndrome (MDS) who need a transplant…

This study is testing if a short, one-week course of two drugs (lenvatinib and pembrolizumab) given before surgery can help the patient's own immune system fight early-stage triple-negative breast cancer. It will enroll about 12 participants who have not yet had any cancer treatm…

This study is testing if a simple eating schedule, called time-restricted eating, can help pregnant women with severe obesity manage their weight and improve health outcomes for themselves and their babies. Researchers will compare 60 participants who follow a specific daily eati…

This study is testing whether adding the drug cabozantinib to pembrolizumab can help control advanced squamous non-small cell lung cancer for longer. It is for patients whose cancer has not worsened after an initial 4-cycle treatment. The main goal is to see how long patients can…

This study is testing a two-drug maintenance therapy for people with multiple myeloma who have had a stem cell transplant. It is specifically for patients who still have very small amounts of cancer detectable in their bone marrow after the transplant. The goal is to see if the d…

This study is testing if a compound from licorice root, called glycyrrhizin, can help control prostate cancer before surgery. Sixty men scheduled for prostate removal will take either a low dose, high dose, or no dose of the compound for about five weeks before their operation. R…

This study is testing whether eye drops made from substances released by stem cells can help heal persistent corneal wounds that haven't responded to standard treatments. The trial will involve 24 adults with non-healing corneal defects who will use the experimental drops or a pl…

This study is testing whether using a lab test called OncoChoice to help select chemotherapy drugs can better control advanced non-small cell lung cancer that has spread and stopped responding to prior treatments. About 29 patients whose cancer has progressed after at least one p…

This study is testing whether using a blood pressure cuff on the leg can help people who have had a leg amputation above the knee. Researchers want to see if this simple method can improve leg strength, walking ability, and overall activity levels. The study will involve 30 adult…

This early-stage study is testing whether adding targeted, high-dose radiation to standard immunotherapy can better control advanced solid tumors that have spread to multiple sites. It will enroll about 28 patients whose cancer has spread to 3-10 locations and who are already on …

This study is testing whether sending personalized text messages can help older adults with heart failure take better care of themselves. Researchers will enroll 30 participants aged 50+ and randomly assign half to receive about 5 text messages per week for 12 weeks, with reminde…

This study is testing whether slowly increasing the dose of the breast cancer drug abemaciclib over 2-3 weeks can help patients better tolerate the treatment. The goal is to reduce severe diarrhea, a common side effect, so more people can stay on the full, recommended dose. The t…

This study is testing whether multiple myeloma patients who show no detectable cancer after stem cell transplant can safely stop their long-term maintenance medications. Researchers will follow 50 patients who have been on maintenance therapy for at least two years and have undet…

This study is testing whether rinsing the sinuses with a probiotic (a type of 'good' bacteria) is more effective than a simple saltwater rinse for controlling chronic sinusitis. It will involve 60 adults who have had prior sinus surgery and are currently experiencing a flare-up o…

This study is testing if a short course of a low-dose drug called azacitidine, given before surgery, can help the body's own immune cells better attack high-risk, early-stage breast cancer tumors. Researchers will measure changes in immune cells within the tumor and see if the tr…

This study is testing whether providing free rideshare rides helps Medicaid patients with diabetic eye disease get to their scheduled eye doctor visits. Researchers designed the PRONTO-EYE program with patient input to address transportation as a key barrier to care. They will me…

This study is testing a new device called HIVEN® that aims to help surgeons remove more brain tumor tissue during surgery. The device analyzes the fluid and tissue that is suctioned away during the operation, checking it for a fluorescent dye that highlights cancer cells, and giv…

This study is testing whether a special treadmill training program before knee replacement surgery can help prevent falls during recovery. About 200 people scheduled for knee replacement will be split into two groups: one gets standard fall-prevention advice, and the other gets t…

This study is testing a phone-based coaching program designed to help Latina women who are at high risk for breast cancer. The goal is to see if this support helps more women get recommended cancer screenings and genetic services. The program involves three weekly phone sessions …

This study aims to prevent fatal opioid overdoses on Chicago's West Side by training friends and family members who don't use drugs to become 'harm reduction champions.' These champions learn about life-saving tools like naloxone and are connected with their loved one who uses op…

This study tests a 6-month parent coaching program designed to prevent young children from needing repeat dental surgeries. It focuses on helping parents improve their child's daily tooth brushing and reduce sugary foods and drinks. Community health workers will support 420 famil…

This study is testing a home exercise program designed to improve balance, walking, and thinking skills in people with multiple sclerosis (MS). Participants will be randomly assigned to either a functional balance training group or a gentle stretching group, and all sessions will…

This study aims to find a better way to prevent severe nausea and vomiting caused by chemotherapy given before a stem cell transplant. It will compare two anti-nausea treatments: a skin patch worn for a week versus a standard intravenous (IV) drug. Researchers want to see which m…

This study is testing whether two dietary approaches can help women undergoing chemotherapy for breast cancer. Researchers want to see if eating only during an 8-hour window each day (time-restricted eating) or combining that with a Mediterranean-style diet reduces treatment side…

This study is testing a 12-week home rehabilitation program for adults who have had a stroke. The program combines functional electrical stimulation (FES), which uses gentle electrical pulses to activate leg muscles, with specific exercises aimed at improving walking and balance.…

This study is testing a non-drug method to see if it can help people with knee arthritis and chronic low back pain move better and feel better. Researchers will temporarily restrict blood flow to a participant's thigh for short periods over two weeks. The goal is to see if this i…

This study is testing whether using a meditation app for one month can help young people on probation in the Chicago area. Researchers want to see if the app improves their ability to manage emotions, reduce substance use problems, and make healthier choices. The study will enrol…

This study is testing whether helping Black adults with chronic kidney disease reduce their sitting time can improve their quality of life. Half of the 40 participants will receive support to sit less, while the other half will receive general kidney disease education. Researcher…

This study is testing if a 6-month, internet-delivered walking program can help improve slowed thinking speed and memory in people with multiple sclerosis (MS). Researchers will enroll 280 physically inactive adults with MS who have mild walking disability and self-reported 'brai…

This study is testing if a fun, virtual reality therapy using dance and video games can help people who have had a stroke improve their physical function, balance, and daily activity. It will compare this new approach to standard rehabilitation therapy to see which is more effect…

This study is testing whether a virtual sleep therapy program can help people with type 1 diabetes who also have insomnia. Researchers want to see if improving sleep leads to better blood sugar control and quality of life. They will compare 15 participants receiving sleep therapy…

This study is testing a health coaching program designed to help adults with mental illness improve their well-being and return to an active life after major disruptions like the COVID-19 pandemic. The program uses coaching, motivational techniques, and online tools to help parti…

This study is testing a home-based exercise program designed specifically for African-Americans with multiple sclerosis (MS) who live in rural areas. Researchers want to see if this tailored program can help improve walking problems, reduce symptoms like fatigue, and boost qualit…

This study is testing whether a simple program combining muscle relaxation exercises and walking is practical and helpful for reducing fatigue in adults with end-stage kidney disease who are on dialysis. Researchers will work with 40 participants to see if they can stick with the…

This study is testing whether a smartphone-based mindfulness program is practical and helpful for teens and young adults with sickle cell disease. Participants will use the app for about 8 weeks to try to manage their chronic pain and sleep problems. The main goal is to see if pe…

This study is testing a family support program designed to help refugee families cope with stress, trauma, and mental health challenges. The program brings families together in groups led by fellow refugees to build community support and improve family relationships. Researchers …

This study is testing whether a specific, long-term exercise program can help U.S. veterans feel better. It will see if the workouts improve body composition, physical strength, and reduce symptoms of pain, fatigue, depression, and PTSD. Over 18 months, 25 participants will atten…

This study aims to understand why people who have had a stroke have trouble coordinating their legs while walking. Researchers will measure brain and nerve activity in 50 participants with chronic stroke to see how it relates to walking problems. The goal is to gather information…

This study aims to better understand Amyotrophic Lateral Sclerosis (ALS) by collecting detailed information from patients. Researchers will gather medical data during life and, with consent, perform rapid autopsies after death to bank tissue. The goal is to identify reliable mark…

This study aims to find the best way to offer cancer genetic testing to patients at community health centers. Researchers will compare two different service models: one where the primary doctor handles testing directly, and another with extra patient support and navigation. The g…

This study is creating a digital program designed to help East Asian immigrants with cancer talk with their families about their future care wishes. Researchers will first interview religious leaders to understand cultural barriers, then develop and test the program with 27 patie…

This study tests a new way to find more people with undiagnosed HIV in South Africa, especially men who are often reluctant to get tested. It asks people who are newly diagnosed to invite friends and family members they think could benefit from an HIV test, creating a chain of pe…

This study aims to understand how obesity harms blood vessels and whether exercise or weight loss surgery can reverse this damage by affecting how genes are turned on or off. Researchers will study 80 obese adults approved for weight loss surgery, comparing them to non-obese peop…