University Of Illinois At Chicago

This study tests whether injecting stem cells from a donor's bone marrow around the eye can help heal corneal ulcers that haven't improved with standard treatments. About 38 adults with persistent damage to the eye's surface will receive the injection and be monitored for up to 9…

This study looks at whether using smartphone apps and sensor devices, along with personalized text messages, can help people with chronic heart failure stick to their self-care routines and reduce time spent in the hospital or risk of death. About 360 adults with Stage C heart fa…

This study tests whether using a tool called OncoChoice to select chemotherapy can help people with advanced non-small cell lung cancer (NSCLC) that has spread. About 29 adults who have already tried at least one other treatment will receive chemotherapy chosen by OncoChoice. The…

This study looks at whether people with early-stage HR+HER2- breast cancer can stay on a higher, FDA-approved dose of abemaciclib (150mg twice daily) for longer. About 50 participants will take the drug alongside hormone therapy after surgery. The goal is to see if this approach …

This study aims to help Latina women who have a higher chance of getting breast cancer due to genetics or life challenges. Researchers will provide three phone sessions to guide participants toward recommended screening and genetic testing. The goal is to see if this support help…

This study tests whether a new therapy that combines rewards for staying sober with problem-solving skills can help young adults (ages 18-24) with alcohol use disorder quit drinking. About 104 participants will be split into two groups: one gets the new combined therapy, the othe…

This study tests a temporary magnetic device that sticks to the skin to help close the eyelids in people who cannot fully shut their eyes (lagophthalmos), which can lead to corneal damage. About 25 adults aged 18–80 with this condition will try the device to see if it provides ad…

This study tests a 6-month program called PROTECT that helps caregivers of young children improve tooth brushing and reduce sugar intake after dental surgery. The goal is to prevent cavities from coming back and avoid the need for more surgeries. About 420 caregivers and their ch…

This study tests whether a one-month meditation app can help 300 youth on probation (ages 13-20) reduce cannabis use and risky sexual behaviors. Participants use the app and researchers track changes in emotion regulation and substance use. The goal is to see if the app is both e…

This early-phase study tests whether giving targeted radiation to up to 10 tumor spots can improve the effects of immunotherapy in people with advanced solid tumors that have spread to 3-10 places in the body. About 28 adults will receive the combined treatment, and researchers w…

This study tests a stem cell transplant from a half-matched family donor for people with severe sickle cell disease. Participants receive low-dose radiation and chemotherapy before the transplant to help the new cells take hold. The main goal is to see if the donor cells successf…

This study tests a free rideshare service to help diabetic retinopathy patients with Medicaid get to their eye doctor appointments. The goal is to see if providing transportation helps patients attend visits more regularly, which can prevent vision loss. About 60 English-speaking…

This study tests whether eye drops made from stem cell secretions can heal persistent corneal defects that haven't improved with standard treatments. Twenty-four adults will receive either the active drops or a placebo for 8 weeks, with follow-up through day 70. The main goal is …

This study tests whether adding a precise form of radiation (IM-TMI) to the usual chemotherapy before a stem cell transplant can kill more cancer cells in the bone marrow and lower the chance of the disease coming back. It involves 27 adults aged 18-75 with acute leukemia or myel…

This study tests a program to help Black adults with chronic kidney disease (CKD) reduce their sitting time. Half of the 40 participants will get the program, while the other half receives general CKD education. The goal is to see if reducing sedentary time improves health and qu…

This study looks at whether limiting eating to a specific time window each day (time-restricted eating) is safe and doable for pregnant women with severe obesity. Researchers will enroll 60 women in their second and third trimesters to see if this approach helps control weight an…

This study tests a 12-week program for Black women who have had breast cancer and also have high blood pressure or obesity. The program includes grocery delivery, cooking classes, and nutrition education to help them eat better and control blood pressure. The goal is to see if th…

This study tests a natural compound from licorice root (glycyrrhizin) in 60 men with prostate cancer who are scheduled for surgery. Participants take the extract daily before their operation to see if it lowers PSA levels and is safe. The goal is to learn if this supplement can h…

This study is for people with early-stage triple-negative breast cancer who are scheduled for surgery. Before surgery, they will receive two drugs: lenvatinib (taken daily for 7 days) and one dose of pembrolizumab (given by IV). The goal is to see if this short treatment can incr…

This study aims to reduce opioid overdose deaths on Chicago's West side by training non-drug-using friends and family members of people who use opioids to become harm reduction champions. Participants will learn about harm reduction tools like naloxone and fentanyl test strips, a…

This study tests a completely oral (pill-based) chemotherapy combination called CMC for people with early-stage breast cancer who have had surgery. The goal is to see if this all-oral regimen is as effective and safer than standard IV chemo. About 25 adults will take three differ…

This study tests whether a combination of two drugs, cabozantinib and pembrolizumab, can help keep advanced squamous non-small cell lung cancer from growing after initial treatment. About 36 adults whose cancer was controlled after standard chemotherapy plus pembrolizumab will re…

This study is testing whether a two-drug maintenance therapy can help control multiple myeloma in patients who still have small amounts of cancer cells after a stem cell transplant. The treatment involves regular infusions of one drug and daily pills of another, taken long-term t…

This study tests whether taking a probiotic called LP299V® twice daily can help pregnant women at risk of iron deficiency anemia absorb more iron from their diet. Researchers will enroll 250 women and follow them from early pregnancy through labor, measuring iron levels in blood …

This study tests if a special treadmill training program before total knee replacement surgery can help prevent falls afterward. People planning knee surgery will either get fall-prevention tips alone or tips plus two weeks of treadmill training that mimics tripping. Researchers …

This study aims to prevent unnecessary deaths from cervical cancer in Senegal by helping more women get screened early. Researchers will adapt a patient navigation program for both urban and rural areas, addressing barriers like stigma and misinformation. About 900 women and heal…

This study tests a program that teaches Black male caregivers how to talk to and support the Black girls in their lives to reduce their risk of HIV, other sexually transmitted infections, and sexual violence. About 612 pairs of caregivers and girls aged 14-18 will take part. The …

This study looks at whether time-restricted eating (eating all food within an 8-hour window each day) is practical and helpful for people starting chemotherapy for early-stage or advanced breast cancer. Researchers will test three different eating windows compared to a control gr…

This study tests whether combining progressive muscle relaxation with a walking program can help reduce fatigue in adults with end-stage kidney disease who are on dialysis. About 40 participants will try the program for 12 weeks. The goal is to see if the approach is practical an…

This study tests whether a specially designed, at-home exercise program can improve walking, reduce fatigue, and enhance quality of life for African-Americans with multiple sclerosis who live in rural areas. About 100 participants will be randomly assigned to either the exercise …

This study tests whether a gentle electrical stimulation applied to leg muscles can improve balance and walking in people who have had a stroke. Twenty participants with chronic stroke will walk on different surfaces and experience simulated slips or trips, with and without the s…

This study tests a 12-week mindful walking program for older South Asian family caregivers (age 45+) who care for someone with cognitive disabilities and feel stressed. Half of the 50 participants will learn mindful walking and use a Fitbit, while the other half continues usual c…

This study tests whether a skin patch (transdermal granisetron) works better than a standard pill (ondansetron) for preventing nausea and vomiting caused by chemotherapy in patients receiving a stem cell transplant. About 90 adults aged 18-75 will take part. The goal is to find a…

This study is testing whether a focused muscle contraction exercise program can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Participants will complete 90 exercise sessions and 4 testin…

This study looks at whether using a blood pressure cuff on the thigh can make leg muscles stronger and improve walking in people who have lost a leg. Researchers will measure strength, walking ability, and daily activity before and after the intervention. The study involves 30 ad…

This study looks at whether following a Mediterranean diet can help reduce chronic pain in people with sickle cell disease. Researchers will compare pain levels when participants eat a Mediterranean diet versus their usual diet. The study involves 30 adults with sickle cell disea…

This early study tests whether a type of talk therapy for insomnia (CBTi) can improve sleep, blood sugar control, and quality of life in adults with type 1 diabetes. Fifteen participants will either get 8 virtual therapy sessions or health education emails and calls. The study fo…

This study looks at whether a smartphone-based mindfulness program is practical and helpful for teens and young adults (ages 15-39) with sickle cell disease who have chronic pain and sleep problems. Participants use a guided mindfulness app for about 8 weeks. The goal is to see i…

This study tests a program that uses health coaching, motivational interviewing, and online wellness tools to help adults with serious mental illness return to active lives after major disruptions like the COVID-19 pandemic. The study will enroll 60 participants from community me…

This study tests a non-drug approach for people with knee osteoarthritis and low back pain. For two weeks, participants will have a cuff on one thigh that briefly stops blood flow for 5 minutes at a time, repeated over 50 minutes every other day. The goal is to see if this improv…

This study tests whether an internet-based physical activity program can improve cognitive processing speed (how quickly you think) in people with multiple sclerosis who have mild walking problems. Researchers will compare the exercise program to an active control group in 280 pa…

This study tests whether a 12-week home program using mild electrical pulses to leg muscles, combined with practice of daily tasks, can improve walking, balance, and mobility in adults who had a stroke at least 6 months ago. Thirty participants will use a device and tablet at hom…

This study explores whether fun activities like dance and video games can help people who have had a stroke improve their balance, movement, and daily function. Researchers will compare these alternative therapies to standard rehabilitation in 120 adults aged 18 to 90. The goal i…

This study tests whether rinsing the sinuses with a probiotic solution can reduce symptoms of chronic sinusitis better than a standard saltwater rinse. Researchers will enroll 60 adults who have had sinus surgery in the past. Participants will use the rinse daily and report chang…

This study looks at whether taking melatonin can improve sleep and daily body rhythms in people with diabetic retinopathy, an eye problem caused by diabetes. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65. The goal is to see if a simple supplemen…

This study tests whether personalized text messages can help older adults (age 50+) with heart failure improve their self-care, like taking medications correctly and following a heart-healthy diet. Participants will be randomly assigned to receive either usual care or usual care …

This study tests whether a home-based balance exercise program can improve both physical and cognitive symptoms in people with multiple sclerosis (MS). 75 adults with MS will be randomly assigned to either the balance program or a stretching routine for 4 months. All sessions are…

This study tests whether using mild brain stimulation before walking therapy can help people who have had a stroke walk better. About 100 adults who had a stroke at least 3 months ago and still have trouble walking will take part. The goal is to see if this approach improves walk…

This study looks at whether eating only during an 8-hour window each day (time-restricted eating) can help women with breast cancer have fewer side effects and better quality of life during chemotherapy. Some participants will also follow a Mediterranean diet. The study involves …

This study looks at two different methods of providing cancer genetic testing to patients in community health centers. One method lets primary care doctors order the test directly, while the other uses a standard approach with extra support from a patient navigator. Researchers w…

This study is testing whether an artificial intelligence (AI) tool called Sybil can better predict lung cancer risk than current methods. Researchers will also see if expanding screening guidelines to include more smokers can catch cancers earlier. About 2,500 people aged 50-80 w…

This study looks at why people who have had a stroke often have trouble coordinating their legs when walking. Researchers will measure brain and nerve signals in 50 adults with chronic stroke to find out what causes these coordination problems. The goal is to gather knowledge tha…

This study tests a new way to find undiagnosed HIV cases in South Africa by asking people who just learned they have HIV to recruit their friends and acquaintances for testing. The goal is to reach men and others who avoid testing due to stigma. Researchers will compare clinics u…

This study tests whether people with multiple myeloma who have no detectable cancer cells (called minimal residual disease negative) can safely stop their daily maintenance drugs after a stem cell transplant. Researchers will watch 50 participants for one year to see if the cance…

This study looks at how 400 adults (ages 50–80) who smoke or used to smoke feel about an artificial intelligence tool that estimates their risk of getting lung cancer in the next 3 years. Researchers will survey participants before and after they receive their risk results to mea…

This study is creating a digital program to help East Asian immigrants who have cancer start conversations with their family about future medical care. The program is designed to be culturally sensitive and build emotional strength. Researchers will test how easy and acceptable t…

This study is for people with high-risk early-stage breast cancer. It tests whether taking a low dose of the drug azacitidine before surgery can increase immune cells inside the tumor. The goal is to see if this approach can make the body's own defenses fight the cancer more effe…

This study tests a new method to detect leftover brain tumor cells during surgery by analyzing waste from the suction device. It includes 8 adults with suspected high-grade gliomas or other brain tumors. The goal is to see if this approach can find tumor cells that are missed by …

This study looks at how being obese changes your DNA and harms blood vessels. Researchers want to see if 12 weeks of aerobic exercise can reverse these changes. 80 adults scheduled for weight-loss surgery will take part. The goal is to understand the body's inner workings, not to…

This study looks at whether a program called Coffee and Family Education and Support (CAFES2) helps refugee families from Arabic-speaking countries feel less depressed, anxious, or stressed. About 74 families in Chicago will take part. The program is led by trained peers and focu…

This study collects spinal cord and brain tissues, along with MRI scans, from 40 adults with ALS after they pass away. The goal is to find biological markers that show how the disease progresses. By linking imaging data with genetic and tissue changes, researchers hope to better …