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Zapping the brain to help stroke survivors walk better

NCT ID NCT04477330

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a mild brain stimulation technique called tDCS, combined with treadmill training, can improve walking in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months past their first stroke and have trouble walking. The goal is to see if this approach speeds up recovery and helps understand how the brain changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS)
What this could lead to
If it works, this could lead to a more effective gait rehabilitation protocol for people with chronic stroke, improving walking speed and quality of life.
What could go wrong
This is an early-stage study with no phase, so results are uncertain. The intervention combines several techniques, making it hard to know which part helps. Benefits may not apply to all stroke survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2020

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age greater than 18 years * First ever monohemispheric stroke \> 3 months since onset * Residual hemiparetic gait deficits (e.g. abnormal gait pattern) * Able to walk for 5 minutes at self-paced speed. Handheld assistive device is acceptable. * Walking speed lesser than 1.2 m/s * Lower limb Fugl-Meyer Motor score between 15-30 * At least 5 deg of ankle dorsiflexion necessary to perform the ankle-tracking task Exclusion Criteria: * General exclusion criteria * Severe osteoporosis * Contracture-limiting range of motion of lower limb * Score of more than 2 on the Modified Ashworth Scale (indicating increased muscle tone through ankle range of motion) * Uncontrolled anti-spasticity medications during the study period * Score less than 6 on the Fugl-Meyer Sensory Assessment Scale for the Lower Limb * Cardiorespiratory or metabolic diseases (e.g. cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema) * Unhealed decubiti, persistent infection * Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)\<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task. * Lesions involving the brainstem and cerebellum * Failure to pass the graded exercise stress test TMS exclusion criteria * Implanted cardiac pacemaker * Metal implants in the head or face * Unexplained, recurring headaches * History of seizures or epilepsy * Currently under medication that could increase motor excitability and lower seizure threshold * Skull abnormalities or fractures * Concussion within the last 6 months * Currently pregnant tDCS exclusion criteria * Skin hypersensitivity * History of contact dermatitits * History of allodynia and/or hyperalgesia * Any other skin or scalp condition that could be aggravated by tDCS

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Physical Therapy

    RECRUITING

    Chicago, Illinois, 60612, United States

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