Zapping the brain to help stroke survivors walk better
NCT ID NCT04477330
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a mild brain stimulation technique called tDCS, combined with treadmill training, can improve walking in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months past their first stroke and have trouble walking. The goal is to see if this approach speeds up recovery and helps understand how the brain changes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial direct current stimulation (tDCS)
- What this could lead to
- If it works, this could lead to a more effective gait rehabilitation protocol for people with chronic stroke, improving walking speed and quality of life.
- What could go wrong
- This is an early-stage study with no phase, so results are uncertain. The intervention combines several techniques, making it hard to know which part helps. Benefits may not apply to all stroke survivors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2020
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age greater than 18 years * First ever monohemispheric stroke \> 3 months since onset * Residual hemiparetic gait deficits (e.g. abnormal gait pattern) * Able to walk for 5 minutes at self-paced speed. Handheld assistive device is acceptable. * Walking speed lesser than 1.2 m/s * Lower limb Fugl-Meyer Motor score between 15-30 * At least 5 deg of ankle dorsiflexion necessary to perform the ankle-tracking task Exclusion Criteria: * General exclusion criteria * Severe osteoporosis * Contracture-limiting range of motion of lower limb * Score of more than 2 on the Modified Ashworth Scale (indicating increased muscle tone through ankle range of motion) * Uncontrolled anti-spasticity medications during the study period * Score less than 6 on the Fugl-Meyer Sensory Assessment Scale for the Lower Limb * Cardiorespiratory or metabolic diseases (e.g. cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema) * Unhealed decubiti, persistent infection * Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)\<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task. * Lesions involving the brainstem and cerebellum * Failure to pass the graded exercise stress test TMS exclusion criteria * Implanted cardiac pacemaker * Metal implants in the head or face * Unexplained, recurring headaches * History of seizures or epilepsy * Currently under medication that could increase motor excitability and lower seizure threshold * Skull abnormalities or fractures * Concussion within the last 6 months * Currently pregnant tDCS exclusion criteria * Skin hypersensitivity * History of contact dermatitits * History of allodynia and/or hyperalgesia * Any other skin or scalp condition that could be aggravated by tDCS
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Physical Therapy
RECRUITINGChicago, Illinois, 60612, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Robot could let stroke patients rehab their hands at home without a therapist
- Moving patterns may help stroke survivors read faster
- Vibrating wearables put stroke walking to the test
- Robot plus electrical stimulation aims to rebuild arm movement after stroke
- Can a checklist and heart monitor stop repeat strokes?
- Heart hole or stroke trigger? global registry tracks who gets closure and what happens next