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Simple cuff trick may boost leg strength after amputation

NCT ID NCT05929508

Symptom relief Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether using a blood pressure cuff on the thigh can make leg muscles stronger and improve walking in people who have lost a leg above the knee. Researchers will measure strength, walking ability, and daily activity before and after the intervention. The goal is to find a simple, non-drug way to help people move better after a traumatic amputation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least 18 years old * History of lower limb unilateral transfemoral amputation. * At least two years post lower limb amputation * Able to ambulate independently without the use of aids (i.e., walking cane). * Able to walk at least 10 minutes continuously without stopping. * Has a safe residuum with no open wounds on either the residual or intact limb. * Has a prosthetic limb with materials that are sound and safe to withstand the mobility requirements of the study. Exclusion Criteria: * Younger than 18 years old. * Inability to give informed consent. * Neurological disorder that affects gait. * Participants with significant metal (greater than one orthopaedic screw) in either the residual limb or the sound/intact limb * Participants who begin taking medications or change dosage of medications that could affect gait, balance, and cardiovascular function during the course of the study. * Currently pregnant (or intend to become pregnant while participating in study). * History of any condition where fatiguing contractions or resisted leg contractions are contraindicated. * Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. open wounds in the leg). * History of uncontrolled hypertension. * History of heart failure. * Head injury within the previous 6 months. * Seizure disorder. * History of vascular disease. * History of thrombosis. * History of sickle cell trait. * History of genetic disease

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Traumatic amputation of lower extremity

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • UIC Physical Therapy Faculty Practice

    RECRUITING

    Chicago, Illinois, 60608, United States

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