University Of Illinois At Chicago

This phase 2 trial is testing whether a new drug called RiMO-301, given alongside radiation and the immunotherapy pembrolizumab (Keytruda), can shrink tumors before surgery in people with resectable, locally advanced head and neck cancer. The study will measure how many patients'…

This trial tests whether a 7-day course of antibiotics after draining a first-time perianal abscess can stop an anal fistula from forming. Adults with a first abscess are randomly assigned to receive antibiotics or not, then followed for up to 12 months. The goal is to see if ant…

Researchers are testing whether adding atrasentan to standard supportive care improves kidney structure and function in adults with IgA nephropathy, a condition where the immune system damages the kidneys. About 20 participants will take atrasentan 0.75 mg once daily for 52 weeks…

This trial tests whether giving hydrocortisone during and right after pancreatic surgery can lower the risk of a postoperative pancreatic fistula, a serious leak of digestive fluids. About 20 adults with pancreatic, duodenal, or bile duct cancer will be randomly assigned to recei…

This study tests whether adding mobile health tools—like smartphone apps, connected scales, blood pressure monitors, and activity trackers—to standard cardiac rehab helps heart patients monitor their health and stick to healthy habits at home. The trial enrolls adults who have ha…

This trial tests whether an anatomical prefabricated healing abutment (AHA) — a healing cap shaped like a natural tooth — preserves soft tissue and bone better than a standard cylindrical one after immediate implant placement. Adults needing a hopeless molar extracted and an impl…

This study tests whether the drug elranatamab can help keep plasmablastic lymphoma, a rare and aggressive blood cancer, from returning after initial chemotherapy. About 17 adults with or without HIV who have already responded to first treatment will receive elranatamab injections…

This study tests a program called On Track for Wellness, which combines Fitbit activity trackers with health education and goal setting. The goal is to help 365 people recently diagnosed with psychosis improve their sleep and increase physical activity. Researchers want to see if…

This study tests whether combining minimally invasive surgery with a drug called deferoxamine helps people recover better after a brain hemorrhage. The surgery removes the blood clot, while the drug may protect brain cells. About 240 adults with moderate to severe bleeding will b…

This study tests a new cognitive-motor training program for older adults with mild cognitive impairment (MCI), an early stage of dementia. The program combines brain games with balance exercises using computer vision. Researchers want to see if it improves thinking, walking, phys…

This study tests whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults aged 60 to 79 who are at higher risk for Alzheimer's disease. Participants will be randomly assigned to either the exercise program or their usu…

This trial tests whether a smartphone-based mindfulness program can help adolescents and young adults with sickle cell disease manage chronic pain and sleep problems. Participants are randomly assigned to either use the mindfulness app for about 8 weeks or receive usual care. The…

This trial tests whether giving patients a prescription for haloperidol to use as needed at home can help control symptoms of cannabinoid hyperemesis syndrome — a condition marked by severe nausea, vomiting, and abdominal pain from heavy cannabis use. The goal is to see if having…

This trial tests whether personalizing content or adding human support increases how much healthcare workers use a digital mental health program. The program teaches cognitive behavioral skills like activity scheduling and mood tracking. Researchers will compare a standard versio…

This study looks at whether adding the drug bupropion (Wellbutrin) to standard hormone therapy can help women with early-stage breast cancer who have lost interest in sex. About 100 women will be randomly assigned to receive either their usual hormone therapy alone or with buprop…

This study tests whether a low dose of olanzapine, a drug often used for nausea, can help gastric cancer patients avoid weight loss and keep their appetite during chemotherapy before surgery. About 26 adults with stomach cancer will be randomly assigned to receive olanzapine or s…

This trial tests whether a 16-week remote physical activity program, including online newsletters and video coaching, can improve motivation and behavior in people newly diagnosed with multiple sclerosis (within the last 2 years). Participants will wear a Fitbit and log steps whi…

This study tests whether acupuncture can help breast cancer survivors who are on hormone therapy and still dealing with pain, fatigue, and poor sleep. Researchers will give a standardized acupuncture treatment and measure changes in these symptoms. The goal is to find out if acup…

This study tests two non-invasive treatments—ischemic conditioning (using a blood pressure cuff to briefly restrict blood flow) and neuromuscular electrical stimulation (mild electrical pulses to trigger muscle contractions)—in 24 adults with above- or below-knee amputation. Part…

This study tests a 16-week home-based exercise program for people with Parkinson's disease. Fifty participants will either do aerobic and resistance training or just stretching. The goal is to see if the program increases daily physical activity, improves thinking, and enhances q…

This study looks at whether a 6-week program that combines problem-solving therapy with small rewards can help new mothers feel less depressed and drink less alcohol. About 30 mothers who gave birth in the last year will take part. Half will get the program, and the other half wi…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens aged 13-24 who use Chicago Park District programs. About 268 participants will either get access to this program or a digital CBT workbook. The goal is to see if the program help…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study looks at whether community health workers (CHWs) can effectively provide a mental health program to Spanish-speaking Latine parents who have symptoms of depression, anxiety, or traumatic stress. About 52 parents will either get the program right away or after a 5-month…

This study tests a new education program for parents of children who just got a feeding tube (like a G-tube or NG-tube). The program teaches parents how to care for the tube, get supplies, and handle problems. Researchers want to see if this helps parents feel more confident and …

This study explores what helps young deaf or hard-of-hearing children, who primarily use spoken language, learn grammar. It compares whether visual speech cues (like watching a face) or nonlinguistic cues (like colored shapes) better support grammar learning, and whether shorter …

This study will have 10 dental students wear Apple Watches to monitor their heart rate while treating both special-needs and non-special-needs patients. Researchers want to see if stress levels differ between the two types of care. The goal is to better understand occupational st…

This study will have about 12 endodontists (dental specialists) wear an Apple Watch during routine root canal procedures to track their heart rate changes. A researcher will note the different stages of treatment to see which parts are most stressful. The goal is to better unders…

This study will test custom smartphone apps and thinking tests to see if they can accurately measure when a patient is ready to leave the hospital alone after anesthesia. Researchers will enroll 1,000 adults having surgery and compare their test results before and after the proce…

This study tests a new care system for people with opioid use disorder across the University of Illinois Hospital and Clinics. Researchers want to see if it increases screening, helps patients stay in care, boosts use of addiction medications, and reduces opioid-related deaths. O…

This study will test whether tiny particles released during cooking (like frying and grilling) can temporarily affect memory and lung function. Fifteen healthy adults will spend two separate 6-hour sessions in a special room: one with clean air and one with typical cooking fumes.…

This study tests a culturally tailored communication tool to help dentists discuss oral and pharyngeal cancers with Black men. Researchers will train dental providers and then pilot the tool in community settings with 50 Black men. The goal is to see if the tool improves comfort,…

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This early-phase study will give 144 healthy young adults (ages 18-21) a single dose of THC (7.5 mg) or a placebo in a capsule, then use brain scans and behavioral tasks to measure how THC affects mood, reward processing, and learning. The goal is to understand why some people re…