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Robot-Assisted knee surgery: no cement may mean better recovery

NCT ID NCT06929871

Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of robotic-arm assisted knee replacement surgery in 120 people with knee osteoarthritis. One group gets cementless implants, the other gets cemented implants. The main goal is to see which approach helps patients 'forget' they have an artificial knee during daily activities.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mako robotic-arm assisted total knee arthroplasty with either cementless or cemented implants
What this could lead to
If successful, this could show that cementless robotic-assisted knee replacements lead to better long-term joint awareness and stability than cemented ones.
What could go wrong
This is a relatively small, early-stage trial (120 participants) comparing two surgical techniques. Results may not apply to all patients, and individual outcomes vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Aug 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient has symptomatic knee osteoarthritis requiring primary TKA 2. Patient and surgeon are in agreement that TKA is the most appropriate treatment 3. Patient is fit for surgical intervention following review by surgeon and anaesthetist 4. Patient is over 18 years old at time of surgery 5. Gender: male and female 6. Patient must be capable of giving informed consent and agree to comply with the postoperative review program 7. Patient must have sufficient postoperative mobility to attend follow-up clinics and allow for radiographs to be taken Exclusion Criteria: 1. Patient is not suitable for routine primary TKA e.g. patient has ligament deficiency that requires a constrained prosthesis 2. Patient has bone loss that requires augmentation 3. Patient is not medically fit for surgical intervention 4. Patient requires revision surgery following previously failed correctional osteotomy or ipsilateral TKA 5. Patient has a DEXA scan with T-score \< -2.5 at any point 6. Patient is immobile or has another neurological condition affecting musculoskeletal function 7. Patient is less than 18 years at time of surgery 8. Patient is unable or unwilling to sign the informed consent form specific to this study 9. Patient is unable to attend the follow-up programme 10. Previous pathological fracture

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis (OA) of the knee Total knee arthroplasty Total knee replacement Total knee replacement surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UCL Hospitals NHS Foundation Trust

    RECRUITING

    London, NW1 2PG, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.