University College, London

This study tests whether using a high-efficiency air filter in the bedroom overnight can reduce inflammation in adult cancer survivors who have high levels of a blood marker called C-reactive protein (CRP). Ten participants in Valencia, Spain, will alternate between a real filter…

This early-phase study tests whether giving the immunotherapy drug ipilimumab before standard surgery and chemoradiation is safe and helps control glioblastoma, a fast-growing brain cancer. About 16 adults with newly diagnosed glioblastoma will receive up to 2 doses of ipilimumab…

This large clinical trial is testing several potential treatments at once to see if they can slow the progression of Parkinson's disease. About 1,200 people with Parkinson's will take part, and most visits can be done from home. The goal is to find treatments that help people sta…

This study looks at whether removing only half of the thyroid gland (hemithyroidectomy) works as well as removing the whole gland (total thyroidectomy) for people with low-risk thyroid cancer. About 456 adults with early-stage thyroid cancer will be randomly assigned to one of th…

This early-stage study tests whether a drug called NIO752 can reduce the brain's production of tau, a protein that forms harmful tangles in Alzheimer's disease. Ten adults with mild to moderate Alzheimer's will receive either the drug or a placebo via spinal injection. The main g…

This early-phase trial tests a new type of CAR T cell therapy for people with multiple myeloma that has come back or stopped responding to treatment. The therapy uses immune cells engineered to recognize and attack myeloma cells, either targeting BCMA alone or both BCMA and CD19.…

This early-phase trial is testing whether a new type of CAR T-cell therapy, made from a patient's own blood cells, is safe for children and adults with T-cell leukemia or lymphoma that has come back or not responded to standard treatments. The therapy targets a protein called CCR…

This study tests new drug combinations to treat pulmonary tuberculosis (TB) faster than the standard 24-week regimen. About 2,500 adults with TB will receive one of 11 combinations, including two new drugs (BTZ-043 and GSK3036656), for 8 to 16 weeks. The goal is to find a treatme…

This study tests a new injectable radioactive drug, Actinium-225 rhPSMA-10.1, in 60 men with advanced prostate cancer that has spread and stopped responding to standard treatments. The drug aims to find and destroy cancer cells with radiation. Researchers will check safety and tu…

This study looks at 1,200 people with atrial fibrillation (an irregular heartbeat) and heart failure. It compares two treatments: catheter ablation (a procedure to fix the heart's rhythm) plus standard medications, versus medications alone. The goal is to see if ablation reduces …

This study tests if longer, higher-dose antibiotics combined with a urinary antiseptic can better control chronic urinary tract infections (UTI) than standard care. Chronic UTI causes daily symptoms like pain and frequent urination, and standard treatments often fail. The trial w…

This study tests whether proton beam therapy can help people with a type of lung cancer called malignant pleural mesothelioma. About 148 adults with early-stage disease will receive radiation to one side of the chest. The goal is to see if this treatment slows cancer growth and i…

This large phase 3 trial tests two new treatments for prostate cancer that has spread. One uses targeted radiation (SABR) to kill cancer spots, the other uses a radioactive drug (PSMA-Lutetium) that seeks out prostate cancer cells. About 3,360 people will take part, and all conti…

This study compares two chemotherapy regimens (ABVD and A2VD) for people with newly diagnosed, early-stage Hodgkin lymphoma. Participants receive 3-4 cycles of chemotherapy, and a PET scan after 2 cycles helps doctors decide if further treatment or radiation is needed. The goal i…

This study tests whether giving the immunotherapy drug pembrolizumab before surgery can safely improve outcomes for people with a specific type of colorectal cancer (MMR-deficient). About 88 participants with high-risk stage 2 or stage 3 disease will receive up to 9 weeks of pemb…

This trial tests whether deep brain stimulation (DBS) can safely reduce seizure frequency in 22 children aged 5-14 with Lennox-Gastaut syndrome, a severe form of epilepsy. Participants receive an implanted device that sends electrical pulses to the brain. The study is double-blin…

This study tests whether a digital home monitoring system called CirrhoCare can reduce unplanned hospital visits for people with decompensated cirrhosis. About 214 adults with cirrhosis will be randomly assigned to use the CirrhoCare system at home or receive standard care. The m…

This study tests a new method called LaserSAFE that uses a special microscope to scan the removed prostate during surgery. The goal is to see if it can quickly find cancer at the edges of the prostate, helping surgeons decide whether to save or remove nearby nerves. About 693 men…

About 60% of newborns get jaundice, which can cause brain damage if untreated. This study tests a smartphone app that uses a photo of the baby's eye to check jaundice levels, potentially reducing unnecessary blood tests. Researchers will enroll 405 babies to see if the app is as …

This study looks at whether finding and protecting an extra artery to the penis (called the accessory pudendal artery) during robotic prostate surgery can help men recover erections. About 40 men with good sexual function before surgery will have their MRI scans checked for this …

This study compares two types of robotic-assisted total knee replacement surgery for people with knee osteoarthritis. One method uses cement to fix the new joint in place, while the other does not. The goal is to see which approach helps patients feel more like their knee is natu…

This study looks at 80 adults to compare the physical and mental health of people with NTM lung disease (a chronic lung infection) and those with bronchiectasis alone. Participants fill out questionnaires and do simple tests on exercise, strength, and nutrition in one visit. The …

This study aims to collect spinal fluid and blood samples from 2,500 people at various stages of Huntington's disease. Researchers will analyze these samples to find biological markers that can help develop new treatments. The study does not test any drug, but focuses on gatherin…

This study tests a 21-day self-guided digital program designed to prepare healthy adults for a supervised psychedelic session with psilocybin. Forty volunteers will be randomly assigned to either a daily meditation or music-listening routine before taking a 25 mg dose of psilocyb…

This study looks at how physical activity fights depression by affecting the brain's reward system, inflammation, and motivation. Researchers will compare aerobic exercise to stretching in 250 adults with moderate depression. The goal is to understand why exercise works, so progr…

This study looks at whether special bladder tests (urodynamics or video-urodynamics) help improve surgical results for women whose incontinence came back after a previous surgery. Thirty women will be randomly assigned to get one of the tests before their treatment. The goal is t…