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Proton therapy takes on rare chest cancer in major trial

NCT ID NCT05655078

Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether proton beam therapy can help people with a rare cancer called malignant pleural mesothelioma. It involves 148 adults whose cancer is on one side of the chest. The goal is to see if this treatment can slow the cancer and help people live longer with fewer side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 148 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Patients ≥18 years of age, with biopsy confirmed MPM and histological subtyping (epithelioid or non-epithelioid) * N0 or N1 and M0 disease * Written informed consent * Patient and local/regional MDT opt for active surveillance and deferral of SACT until clinical or radiological progression * WHO Performance Status 0-1 * Disease confined to one hemithorax based on CT assessment * Adequate pulmonary function * ≥ 40% predicted post-FEV1; * ≥ 40% predicted DLCO/TLCO * Agreement to travel to either proton beam therapy centres (i.e. UCLH or The Christie) if randomised to arm 2 * Agreement to be followed up at a local HIT-Meso trial site * Patient likely able to complete PBT planning based on local assessment Exclusion criteria: * Presence of metastatic or contralateral disease * Cytological diagnosis and/or undetermined histological subtype * Prior thoracic radiotherapy, chemotherapy, immunotherapy for MPM * Prior radical surgery for MPM (extrapleural pneumonectomy or extended pleurectomy decortication or pleurectomy decortication) * Initial systemic therapy or surgery is required and the patient and local/regional MDT do not opt for active surveillance * Involvement of contralateral or supraclavicular lymph nodes * T4 disease with invasion of the myocardium * N2 and/or M1 disease * Presence of new effusion that is not amenable to drainage * WHO Performance Status ≥ 2 * Women who are pregnant or breast feeding * Current or previous malignant disease which may impact on the patient's life expectancy * Patient fitted with a pacemaker or implantable cardioverter-defibrillator (ICD)\\ * Diagnosis of clinically significant interstitial lung disease (ILD), excluding mild fibrosis or incidental findings * Chronic non-malignant disease with an estimated three-year survival rate of less than 20% * Patient with prior thoracic / abdominal radiotherapy for malignancy who was not discussed with sponsor before recruitment

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Conditions

The condition(s) this trial relates to.

malignant pleural mesothelioma Mesothelioma, Malignant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Malignant pleural mesothelioma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    24 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Addenbrooke's Hospital

    RECRUITING

    Cambridge, CB20QQ, United Kingdom

  • Betsi Cadwaladr University Health Board -Glan Clwyd Hospital

    RECRUITING

    Bodelwyddan, LL18 5UJ, United Kingdom

  • Broomfield Hospital

    RECRUITING

    Chelmsford, CM1 7ET, United Kingdom

  • Christie Hospital

    ACTIVE_NOT_RECRUITING

    Manchester, M20 4BX, United Kingdom

  • Clatterbridge Cancer Centre

    RECRUITING

    Liverpool, L78YA, United Kingdom

  • East Sussex Healthcare NHS Trust - Conquest Hospital

    RECRUITING

    Saint Leonards-on-Sea, East Sussex, United Kingdom

  • East Sussex Healthcare NHS Trust - Eastbourne Hospital

    RECRUITING

    Eastbourne, East Sussex, United Kingdom

  • Freeman Hospital

    RECRUITING

    Newcastle upon Tyne, NE77DN, United Kingdom

  • Furness General Hospital

    RECRUITING

    Barrow in Furness, LA14 4LF, United Kingdom

  • Leicester Royal Infirmary

    RECRUITING

    Leicester, LE1 5WW, United Kingdom

  • Maidstone Hospital

    RECRUITING

    Maidstone, ME169QQ, United Kingdom

  • Queen Alexandra Hospital

    RECRUITING

    Portsmouth, Hampshire, United Kingdom

  • Queen Elizabeth Hospital, King's Lynn

    RECRUITING

    Kings Lynn, Norfolk, PE30 4ET, United Kingdom

  • Queens Centre, Castle Hill Hospital

    RECRUITING

    Hull, HU165JQ, United Kingdom

  • Royal Berkshire Hospital

    RECRUITING

    Reading, England, RG15AN, United Kingdom

  • Royal Lancaster Hospital

    RECRUITING

    Lancaster, LA1 4RP, United Kingdom

  • Southend University Hospital

    RECRUITING

    Southend, Essex, SS0 0RY, United Kingdom

  • Southmead Hospital

    RECRUITING

    Bristol, BS105NB, United Kingdom

  • St Bartholomew's Hospital

    RECRUITING

    London, EC1A 7BE, United Kingdom

  • St James University Hospital

    RECRUITING

    Leeds, LS97TF, United Kingdom

  • Torbay Hospital

    RECRUITING

    Torquay, TQ2 7AA, United Kingdom

  • University College London Hospital

    RECRUITING

    London, United Kingdom

  • Velindre Cancer Centre

    RECRUITING

    Cardiff, United Kingdom

  • Weston Park Cancer Centre

    RECRUITING

    Sheffield, S102SJ, United Kingdom

  • Wythenshawe Hospital

    RECRUITING

    Manchester, M23 9LT, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.