University College, London

This study tests whether two heart failure medications, dapagliflozin and spironolactone, can help the heart recover more fully after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months after their valve surgery. …

This study looks at people who have TB-like changes on chest X-rays but test negative for TB bacteria in their spit. It aims to find the shortest effective treatment (8 to 24 weeks) and see if close monitoring without immediate treatment is safe. About 784 adults in high-TB areas…

This study explores whether measuring foot pressure while standing and walking can help detect adolescent idiopathic scoliosis earlier. Researchers will collect data from 500 teens aged 10-18, both with and without scoliosis, using a pressure mat. Machine learning will then analy…

This pilot study in Zimbabwe will test whether trained young mentor mothers (YMMs) can help pregnant and breastfeeding teens and young women (ages 15-24) use HIV prevention tools like PrEP and contraception. About 600 participants will be assigned to receive support from YMMs or …

This study tests whether an intensive 4-week communication program (100 hours of therapy) can improve quality of life for people with aphasia after a stroke. About 334 adults who had a stroke at least 3 months ago will be randomly assigned to the program or usual care. The goal i…

This study tests a headband-like device called Nettle that sends mild electrical pulses to brain areas involved in pain. Twenty adults with chronic migraine will use it at home for 20 minutes daily over three months. The main goal is to see if people can stick with the treatment …

This study tests a new program for young people aged 11-18 who are already getting therapy for emotional issues like anxiety or depression. The program pairs them with a trained worker who helps them find community activities (like sports, arts, or volunteering) that match their …

This study tests whether artificial intelligence can help surgical teams during pituitary tumor removal surgery performed through the nose. The AI watches live video of the operation and shows information about anatomy and surgical steps on tablets for residents and nurses, witho…

This study aims to find out if proteins in eye fluid and special eye scans can predict a scarring complication called PVR after retinal detachment surgery. 50 adults with a first-time retinal detachment will have extra imaging and donate a small fluid sample during their standard…

This study looks at whether people who had a stroke more than 6 months ago and cannot move their fingers can regain that ability. Researchers will use brain stimulation and electrical muscle therapy to see who improves. The goal is to understand which patients are most likely to …