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Can eye scans and fluid predict who will develop a complication after retinal detachment repair?

NCT ID NCT07386678

Knowledge-focused Sponsor: University College, London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study will enroll 50 adults with a specific type of retinal detachment to look for clues in eye fluid and images that might predict a complication called PVR. Participants will receive standard surgery plus extra non-invasive eye scans and a sample of their eye fluid taken during surgery. The goal is to build a risk model and AI tools to better predict PVR.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a way to predict which patients are at risk of a serious complication called PVR after retinal detachment surgery.
What could go wrong
This is an early observational study with only 50 participants. It is not testing a treatment, so it may not directly lead to any new therapy or change in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

* Adults ≥18 years * Uncomplicated primary rhegmatogenous retinal detachment * Moorfields Eye Hospital

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥18 years * Uncomplicated primary rhegmatogenous retinal detachment * PVD present * No PVR-A/B/C * Phakic or pseudophakic. Exclusion Criteria: * Patients \<18 years * Patients lacking capacity * Previous vitrectomy * Previous cryopexy * Aphakia * No fundal view * Diabetic retinopathy of any severity * Retinal detachment secondary to infective causes e.g. acute retinal necrosis, toxoplasmosis scars * Retinal detachment secondary to congenital defects e.g. optic disc pit/coloboma * Exudative retinal detachment * Tractional retinal detachment * Ongoing involvement in another ocular trial.

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Conditions

The condition(s) this trial relates to.

proliferative vitreoretinopathy rhegmatogenous retinal detachment

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Proliferative vitreoretinopathy Proliferative vitreoretinopathy in rhegmatogenous retinal detachment Retinal detachment rhegmatogenous

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Moorfields Eye Hospital

    London, N17 9GZ, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.