Could air be as good as gas for fixing a detached retina?
NCT ID NCT07034469
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether using sterile air during eye surgery for a detached retina works as well as the standard gas bubble. About 150 patients from 10 UK centers will be randomly assigned to receive either air or a fluorinated gas. The main goal is to see if the retina stays reattached after a single surgery at 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- air or fluorinated gas (SF6, C2F6, C3F8) used as tamponade during eye surgery
- What this could lead to
- If air works as well as gas, it could simplify retinal detachment surgery, reduce side effects, and lower costs.
- What could go wrong
- This is a small, early-stage trial (150 patients) testing non-inferiority, so results may not be conclusive. Air might not hold the retina in place as effectively as gas.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2029
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Primary uncomplicated RRD undergoing vitrectomy. * Phakic and pseudophakic eyes * Retinal breaks superiorly between 3 and 9 o'clock, and that are separated by less than 4 clock hours. Exclusion Criteria: * Absence of PVD * Age 40 years or younger * PVR grade C or above * Aphakia or anterior chamber lens * Retinal breaks greater than 1 clock hour in size * Retinal breaks that exist below 3 and 9 o'clock on both the nasal and temporal sides. * Retinal breaks at or posterior to the vessel arcades * Current or previous -6D myopia or greater (or axial length \>26millimetres (mm)) * Chronic RRD judged by the presence of subretinal bands and other signs of -chronicity or by history of visual loss for \>28 days. * Significant inflammation, choroidal detachments, hypotony (\<6 millimetres of mercury (mmHg) preop) * Previous open-globe injury, or endophthalmitis * Current or previous posterior uveitis or choroiditis * Any intraocular surgical procedure within 4 weeks other than laser/cryotherapy * Any other condition that, in the opinion of the investigator, would prevent the participant from granting informed consent or complying with the protocol.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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