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Could air be as good as gas for fixing a detached retina?

NCT ID NCT07034469

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using sterile air during eye surgery for a detached retina works as well as the standard gas bubble. About 150 patients from 10 UK centers will be randomly assigned to receive either air or a fluorinated gas. The main goal is to see if the retina stays reattached after a single surgery at 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
air or fluorinated gas (SF6, C2F6, C3F8) used as tamponade during eye surgery
What this could lead to
If air works as well as gas, it could simplify retinal detachment surgery, reduce side effects, and lower costs.
What could go wrong
This is a small, early-stage trial (150 patients) testing non-inferiority, so results may not be conclusive. Air might not hold the retina in place as effectively as gas.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Primary uncomplicated RRD undergoing vitrectomy. * Phakic and pseudophakic eyes * Retinal breaks superiorly between 3 and 9 o'clock, and that are separated by less than 4 clock hours. Exclusion Criteria: * Absence of PVD * Age 40 years or younger * PVR grade C or above * Aphakia or anterior chamber lens * Retinal breaks greater than 1 clock hour in size * Retinal breaks that exist below 3 and 9 o'clock on both the nasal and temporal sides. * Retinal breaks at or posterior to the vessel arcades * Current or previous -6D myopia or greater (or axial length \>26millimetres (mm)) * Chronic RRD judged by the presence of subretinal bands and other signs of -chronicity or by history of visual loss for \>28 days. * Significant inflammation, choroidal detachments, hypotony (\<6 millimetres of mercury (mmHg) preop) * Previous open-globe injury, or endophthalmitis * Current or previous posterior uveitis or choroiditis * Any intraocular surgical procedure within 4 weeks other than laser/cryotherapy * Any other condition that, in the opinion of the investigator, would prevent the participant from granting informed consent or complying with the protocol.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The official record

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