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Less numbing medicine may work just as well for knee surgery pain

NCT ID NCT06908837

Symptom relief Sponsor: Regionshospitalet Silkeborg Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using 10 mL or 20 mL of numbing medicine around the knee after replacement surgery could reduce the need for strong painkillers. 120 adults having knee replacement took part. The goal was to see if the smaller dose works just as well, with less medication and similar pain control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

120 people

The number who actually took part.

Started

Apr 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled to undergo primary total knee arthroplasty in spinal anesthesia. * Ability to give their written informed consent after having fully understood the contents of the study. * American Society of Anesthesiologists (ASA) physical status 1, 2, or 3. Exclusion Criteria: * Patients who cannot read or speak Danish. * Patients who cannot operate or have access to a smartphone with internet connectivity (required for patient-reported outcome assessment). * Patients with allergies or intolerance to the medicines used in the study. * Patients with a consistent daily intake of opioids preoperatively. * Patients who are dependent on walking aid devices preoperatively. * Patients suffering from alcohol and/or drug abuse - based on the investigator's assessment. * BMI \> 40. * Diagnosed with chronic neurodegenerative disorders.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multimodal analgesic approach Postoperative opioid-related complications Regional anesthesia Total knee arthroplasty

Contacts and locations

Locations

  • Elective Surgery Centre at Silkeborg Regional Hospital

    Silkeborg, Denmark Central Region, 8600, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.