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Can a Cannabis-Like drug cut opioid use after knee surgery?

NCT ID NCT04734080

Symptom relief Sponsor: Hospital for Special Surgery, New York Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether dronabinol, a drug similar to cannabis, can help reduce the need for opioid painkillers after total knee replacement. 114 adults scheduled for knee surgery were randomly given either dronabinol or a placebo before and after their operation. Researchers measured opioid use, pain levels, and recovery time to see if dronabinol made a difference.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

114 people

The number who actually took part.

Started

Mar 2021

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 18-70 years old with osteoarthrosis scheduled for primary unilateral knee arthroplasty with a participating surgeon * Planned use of regional anesthetic technique during surgery involving infiltration between the popliteal artery and the capsule of the posterior knee (IPACK), adductor canal block (ACB) and periarticular injection (PAI) * Ability to follow study protocol Exclusion Criteria: * Patients less than 18 years of age or older than 70 years of age * Contraindication to regional or neuraxial anesthetic * Intended use of general anesthesia * Revision surgery * Chronic opioid use (for \>3 months prior to surgery) * Cannabis/cannabinoid use within the last 3 months * ASA class of IV or greater * Active or history of major mental history (as defined by the Diagnostic and Statistical Manual of Mental Disorders-5 \[DSM-5\]; i.e. major depressive disorder, anxiety, bipolar disorder, schizophrenia) * History of seizures * Use of antidepressants * Use of anticonvulsants * Use of Coumadin * Use of Disulfuram * Use of Metronidazole * Non-English speakers * BMI ≥40 * Sleep Apnea

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Conditions

The condition(s) this trial relates to.

opioid abuse osteoarthritis susceptibility 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opioid use Total knee arthroplasty

Contacts and locations

Locations

  • Hospital for Special Surgery

    New York, New York, 10021, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.