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New pain block may cut opioid use after knee surgery

NCT ID NCT05962970

Symptom relief Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a continuous nerve block (a small tube that delivers numbing medicine for days) can improve pain control and reduce opioid use after knee replacement surgery. Sixty adults having same-day knee replacement were enrolled. The goal was to see if this approach leads to less pain, fewer side effects, and a better recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Oct 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing unilateral primary TKA in the fast track setting. * Patients older than 21 years of age, with American Society of Anesthesiologists (ASA) * Physical status I-III * No alcohol or drug dependency * Sufficient understand and co-operation about the perineural catheter. Exclusion Criteria: * Perioperative complication or discharge delay leading to hospital admission. * Chronic opioid use of morphine 30mg equivalent per day for last 2 consecutive weeks. * Allergy to the study medications; * Coagulopathy and platelet count \< 105/μL; * Patients with contraindications to the insertion of an epidural or adductor canal catheter (severe anatomic abnormalities or history of previous surgery at the site of catheter placement).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Total knee arthroplasty

Contacts and locations

Locations

  • Mount Sinai Hospital, Toronto

    Toronto, Ontario, M5G 1X5, Canada

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