Heartbeat clues may forecast sudden Post-Surgery pain
NCT ID NCT06977191
First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 2 times
Summary
This study looked at whether heart rate variability (HRV) can predict rebound pain after total knee replacement. Rebound pain is a sudden, intense pain that can occur when nerve blocks wear off. Researchers measured HRV before and after surgery in 110 patients and tracked their pain levels. The goal is to see if HRV can help doctors personalize pain management after knee surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors identify patients at risk for rebound pain after knee replacement and tailor pain treatments to each person.
- What could go wrong
- This is a small, completed observational study, not a treatment trial. The results may not apply to all patients or lead to a proven prediction tool.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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115 people
The number who actually took part.
- Started
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May 2025
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients aged 18 to 70 years scheduled for elective unilateral total knee arthroplasty under spinal anesthesia at a tertiary care hospital. All participants will receive multimodal analgesia including peripheral nerve blocks as part of standard care.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 18 and 70 years * American Society of Anesthesiologists (ASA) physical status I-III * Scheduled for elective, unilateral total knee arthroplasty under spinal anesthesia * Planned use of multimodal analgesia including peripheral nerve blocks * Ability to provide written informed consent * Ability to understand and complete pain diaries and questionnaires Exclusion Criteria: * Known allergy to local anesthetics * Contraindications to regional anesthesia * Contraindications to spinal anesthesia * ASA physical status IV or higher * Pregnancy or breastfeeding * Neurological or psychiatric disorders impairing ability to participate or report outcomes * Use of anticoagulant therapy or presence of coagulation disorders * Infection at the proposed injection site * Emergency (non-elective) surgical procedures
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Konya City Hospital
Konya, 42090, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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