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New pain block could cut opioid use after abdominal surgery

NCT ID NCT07331441

Symptom relief Sponsor: Jun Zhang Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 2 times

Summary

This study tests a new nerve block called the External Oblique Intercostal Plane Block (EOIB) to see if it reduces pain and the need for opioids after major upper abdominal surgery. 78 adults having laparoscopic surgery on the stomach, liver, gallbladder, or pancreas will be randomly assigned to receive either the block plus standard pain care or standard care alone. The main goal is to measure total opioid use in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
External Oblique Intercostal Plane Block (EOIB) with ropivacaine
What this could lead to
If it works, this could provide a safer, more effective way to manage pain after major abdominal surgery, reducing opioid use and speeding recovery.
What could go wrong
This is a small, early-stage trial (78 participants). The block may not reduce pain significantly, and there is a risk of side effects like bleeding or infection at the injection site.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 78 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Obtain written informed consent from participants or their legal representatives * Age between 18 and 85 years * American Society of Anesthesiologists (ASA) physical status classification I-III * Scheduled for elective laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) * Expected surgical duration ≥ 2 hours * Ability to use the intravenous patient-controlled analgesia (IV PCA) system Exclusion Criteria: * Hepatic disease (liver enzyme levels ≥ 2× the upper limit of normal) * Renal disease (serum creatinine levels ≥ 2× the upper limit of normal) * Allergy to local anesthetics or known study-related drugs * Pregnancy or lactation * Low surgical incision site (not involving the upper abdominal wall innervated by T6-T10 nerves) * Coagulopathy or current use of anticoagulant medications * Opioid use for more than 2 weeks in the past 6 months

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Conditions

The condition(s) this trial relates to.

agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal surgery Postoperative pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fudan University Shanghai Cancer Center

    RECRUITING

    Shanghai, China

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