Could the 'Love Hormone' ease surgery pain and cut opioid use?
NCT ID NCT06483659
First seen Jan 11, 2026 · Last updated Jun 23, 2026 · Updated 25 times
Summary
This study tests whether giving oxytocin (the 'love hormone') through an IV during surgery can reduce pain and the need for opioid painkillers after a minimally invasive hysterectomy. Researchers will compare oxytocin to a placebo in 152 adults aged 18-65. The goal is to find a safer way to manage post-operative pain.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02215, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Oxytocin (Pitocin)
What this could lead to
If it works, this could offer a new way to manage post-surgery pain and reduce reliance on opioids.
What could go wrong
This is an early phase 2 trial with only 152 participants, so results may not apply broadly. Oxytocin may not outperform placebo for pain relief.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.