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Nerve block showdown: which eases gallbladder surgery pain best?

NCT ID NCT07241949

Symptom relief Sponsor: Cukurova University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study compares two types of nerve blocks (paravertebral block and external oblique intercostal block) to standard pain medicine for people having gallbladder removal surgery. About 147 adults will be randomly assigned to one of three groups to see which approach reduces pain and the need for opioids in the first 24 hours after surgery. The goal is to find a better way to manage pain and speed up recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine (a numbing medicine) and tramadol (a painkiller)
What this could lead to
If one block works better, it could mean less pain and fewer opioids after gallbladder surgery, helping patients recover faster.
What could go wrong
This is a small, early-stage trial, so results may not apply to everyone. Both blocks are procedures with rare risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 147 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 65 years * Scheduled for elective laparoscopic cholecystectomy under general anesthesia * ASA physical status I-III * Able to understand the study procedure and provide informed consent Exclusion Criteria: Patient refusal or inability to provide informed consent Allergy or contraindication to local anesthetics, tramadol, or study medications Coagulopathy or current anticoagulant therapy Local infection at the planned block injection site Severe hepatic or renal impairment Chronic opioid use or opioid dependence Neurological or psychiatric disorders affecting pain perception or communication Pregnancy or breastfeeding Body mass index (BMI) \> 35 kg/m² Conversion to open cholecystectomy during surgery

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Conditions

The condition(s) this trial relates to.

agnosia Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

External oblique intercostal plane block Laparoscopic cholecystectomy Paravertebral block Patient-controlled analgesia Postoperative pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cukurova University Faculty of Medicine

    RECRUITING

    Adana, Turkey (Türkiye)

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