POSTOPERATIVE PAIN

This study tested whether placing a mesh (a supportive screen) during stoma reversal surgery could prevent hernias better than standard closure. 62 patients who had a temporary stoma took part. The researchers measured hernia rates, infections, pain, and hospital stay length.

This study tested two methods of numbing the suprascapular nerve (a nerve in the shoulder) to control pain after arthroscopic shoulder surgery. Sixty adults scheduled for shoulder surgery received either an anterior or posterior nerve block. Researchers measured pain levels, diap…

This study looked at two types of ultrasound-guided nerve blocks for pain after hip replacement surgery in 62 patients aged 65 and older. One group got a PENG block plus a lateral femoral cutaneous nerve block, the other got a PENG block plus a lumbar erector spinae plane block. …

This study looked at whether adding a nerve block near the breastbone to a standard side-chest block can lower opioid painkiller use after breast reduction surgery. 90 women were split into three groups: no block, standard block alone, or standard plus extra block. The main goal …

This study tested whether aromatherapy foot massage can reduce pain, improve sleep, and speed recovery after laparoscopic gallbladder removal. 103 adults received either the massage or standard care. The massage was applied for 10 minutes shortly after surgery and again six hours…

This study looked at whether giving a single high dose of vitamin C along with nerve blocks before knee replacement surgery could reduce pain and help patients recover faster. 73 adults aged 50 to 80 took part. Half received vitamin C through an IV, and the other half got a place…

This study looked at whether applying ice packs for 10 minutes after hemorrhoid surgery can reduce pain and the need for strong painkillers. Researchers compared 429 patients who either received ice packing or standard care. The goal was to see if this simple, low-cost method imp…

This phase 2 trial tested two experimental drugs, HTX-011 and HTX-002, for pain relief after abdominoplasty (tummy tuck) surgery. 277 adults received an injection of the drug or a placebo. The main goal was to measure pain intensity over the first 24 hours. The study is now compl…

This study compared two pain relievers—gabapentin and diclofenac sodium—given before major abdominal surgery to see which one controls pain better afterward. 240 adults took a single dose of one drug an hour before surgery. The goal was to keep pain scores low without needing ext…

This study tested two different nerve block methods—M-TAPA and OSTAP—to see which provides better pain relief after laparoscopic inguinal hernia repair. 90 adults having surgery were randomly assigned to receive one of the blocks or standard painkillers. Researchers measured pain…

This study tested whether letting children play with sand before a tonsillectomy could lower their anxiety and pain. Sixty-eight kids aged 7 to 10 were split into two groups: one did sand play, the other got standard care. Researchers measured anxiety before surgery and pain afte…

This study looked at whether adding a TAP block (a type of nerve block) to standard pain relief after a cesarean section could improve wound healing and reduce stress on the body. 105 women having planned C-sections were randomly assigned to receive either standard pain medicatio…

This study compared two painkillers, nalbuphine and morphine, given through a patient-controlled pump to 80 women recovering from laparoscopic myomectomy (surgery to remove uterine fibroids). The goal was to see which one provides better pain relief and causes fewer side effects.…

This small pilot study tested whether two NSAIDs (ketorolac and diclofenac) work as well as a weak opioid (tramadol) for pain after minimally invasive surgery. Thirty adults received a single dose of one of the three drugs before surgery, and their pain levels were tracked afterw…

This study tested whether a short virtual reality session could help reduce pain and fatigue in patients who just had a liver transplant. 84 patients were split into two groups: one got a 20-minute VR experience, the other got standard care. Researchers measured pain, fatigue, an…

This study tested three different patient positions—lying on the side, on the belly, or sitting up—for giving a nerve block (ESP block) before gallbladder surgery. The goal was to see which position provides the best pain relief and patient satisfaction after the operation. 120 a…

This study tested two types of nerve blocks to see which provides better pain relief for children aged 1 to 6 after hypospadias surgery. Sixty kids received either a pudendal nerve block or a dorsal penile nerve block, both guided by ultrasound. Researchers measured pain levels a…

This study compared two types of nerve blocks (lumbar vs. sacral erector spinae plane block) for pain after single-level lumbar microdiscectomy surgery. 88 adults were enrolled to see which block reduced pain scores and the need for extra painkillers like tramadol. The goal is to…

This study tested a drug called HTX-011, which combines two pain relievers (bupivacaine and meloxicam), given as a nerve block before breast augmentation surgery. The goal was to see if it reduces pain and the need for opioid painkillers after the operation. The trial involved 24…

This study compared two types of nerve blocks—recto-intercostal and external oblique intercostal—for pain relief after laparoscopic gallbladder removal. Sixty adults having elective surgery received one of the two blocks. Researchers measured how much extra painkiller they needed…

This study tested a calcium-phosphate desensitizer applied under composite fillings to see if it reduces post-treatment tooth sensitivity. Fifty adults with cavities received either the desensitizer or no treatment. Pain was measured using a visual scale and a numerical rating. T…

This study tested whether injecting the numbing drug ropivacaine into the chest cavity can reduce severe pain after lung cancer surgery. 90 adults having a thoracotomy for cancer received either ropivacaine or a saltwater placebo every 6 hours for 2 days. The main goal was to see…

This study tested whether elastic therapeutic taping can reduce pain after open-heart surgery (CABG). 195 patients were randomly assigned to receive real tape, placebo tape, or another supportive treatment near the surgical site. Neither patients nor researchers knew who got whic…

This study tested whether a nerve block called an erector spinae plane (ESP) block can reduce pain after lumbar spine surgery. 102 adults were randomly assigned to receive either the ESP block or standard pain treatment. Researchers measured pain scores, opioid use, and how quick…

This study tested two different nerve blocks to control pain right after thyroid surgery. Forty adults received either a cervical erector spinae plane block or a cervical plexus block. Researchers measured how much morphine patients needed and how long until they first asked for …

This study looked at whether a special nerve block called PENG can help people who have partial hip replacement surgery feel less pain and need fewer painkillers. 48 adults having this surgery were split into two groups: one got the nerve block plus usual care, the other got usua…

This study compared two types of nerve blocks (Quadratus Lumborum block and Erector Spinal block) to see which one works better for pain after abdominal surgery. 100 adults having surgery for cancer or gallbladder issues took part. The goal was to measure how much strong pain med…

This study tested whether giving lidocaine through a vein during liver surgery helps reduce pain and the need for strong painkillers afterward. 124 adults having minor liver surgery were randomly assigned to receive either lidocaine or a placebo (salt water). The main goal was to…

This study tested whether a nerve block (suprazygomatic maxillary nerve block) can reduce pain and the need for strong painkillers in children after tonsil and adenoid removal. 114 children aged 6 months to 18 years took part. The block was given during surgery, and some children…

This study tested if adding a rectus sheath block (a nerve block) to general anesthesia helps control pain after abdominal surgery. 46 adults having a midline incision were randomly assigned to get either general anesthesia alone or with the block. Researchers measured pain score…

This study compared two methods for controlling pain after a planned C-section: a nerve block (quadratus lumborum block) and a spinal injection of morphine. 118 women who had a C-section under spinal anesthesia took part. The main goal was to see which method reduced the need for…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) improves pain control after heart surgery. 62 adults having elective heart surgery through a breastbone incision were randomly assigne…

This study looked at 60 adults having chest surgery to compare two types of nerve blocks for pain relief after the operation. One block is called Edge Laminar Block and the other is Serratus Posterior Superior Intercostal Plane Block. The goal was to see which one works better at…

This study looked at whether using a surgical drain after a knee replacement affects pain levels. 60 patients over age 60 were included. The goal was to see if drains, which are commonly used to prevent bleeding, also help with early post-surgery pain. The results help doctors de…

This study looked at 142 adults who needed a root canal on a single-rooted tooth. They were given either octenidine or chlorhexidine as a final rinse during the procedure. The goal was to see which rinse led to less pain in the first 48 hours after treatment. Participants rated t…

This study tested two ways to manage pain in 70 children undergoing chest surgery. One method, the erector spinae plane block, was compared to the standard epidural block. The goal was to see which provides better pain relief and keeps the heart rate and blood pressure more stabl…

This study tested whether using a sonic device (EDDY) during root canal treatment on baby molars reduces pain afterward. Thirty children aged 5-8 with tooth infections received either sonic-activated cleaning or standard cleaning. Pain was measured using a face scale and an AI ap…

This study tested whether wearing noise-cancelling earphones during general anesthesia can lower the chance of moderate to severe pain after major abdominal surgery. Researchers enrolled 304 adults aged 18-70 undergoing elective surgery lasting at least 2 hours. The goal was to s…

This study tested whether giving ibuprofen before hernia surgery could prevent confusion and memory problems in older adults. 76 men aged 65-84 received either ibuprofen or a placebo before their operation. Researchers measured thinking skills, pain levels, and recovery quality f…

This study tested whether combining duloxetine and pregabalin before and after liposuction surgery can reduce pain and the need for strong opioid painkillers. 90 adults undergoing liposuction were given either the drug combo, pregabalin alone, or a placebo. The goal was to see if…

This study tested whether giving acetaminophen through an IV works better than taking it by mouth for pain after total knee replacement. 174 adults having knee surgery with spinal anesthesia were included. Researchers measured pain scores, how much opioid painkiller was needed, a…

This study tested whether using different modes on an electronic apex locator (a tool that measures tooth canal length) during root canal retreatment could reduce pain afterward. 144 adults with infected teeth were split into four groups: one used a standard locator, and three us…

This study tested whether spraying a mix of budesonide and lidocaine directly on the voice box during thyroid surgery could prevent the common problem of sore throat afterward. 96 adults having thyroid surgery with nerve monitoring were randomly assigned to get either the drug mi…

This study tested whether a brief psychiatric session one hour before surgery could help living kidney donors feel less anxious, have more stable vital signs during surgery, and experience less pain afterward. 123 donors took part, with some receiving the therapy and others stand…

This study looked at whether adding magnesium sulfate to a standard numbing medicine (bupivacaine) in a nerve block could improve pain control after a mastectomy. Seventy women having breast cancer surgery received either the standard nerve block or one with added magnesium. The …

This study tested whether applying ice packs over surgical incisions every 4 hours for up to 72 hours can improve patients' recovery after chest, abdomen, or groin surgery. 196 adults were randomly assigned to receive cryotherapy plus standard care or standard care alone. The mai…

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study tested whether a superficial cervical block—a local anesthetic injection in the neck—could lower the amount of opioids patients need after anterior cervical discectomy surgery. Sixty adults scheduled for this surgery were randomly assigned to receive the block or not. …

This study tested two types of nerve blocks (SAP and PECS II) to see if they can reduce pain after coronary artery bypass grafting. 243 adults having elective heart surgery received one of the blocks or standard care. Researchers measured pain scores, opioid use, and recovery tim…

This study compared two types of nerve blocks (ESPB and SPSIPB) to standard pain medicine for controlling pain after video-assisted lung surgery. 110 adults were randomly assigned to one of three groups. The goal was to see which method provides better pain relief and reduces the…

This study tested an experimental pain medication called HTX-011 in 430 adults recovering from bunion surgery. The goal was to see if it reduces pain better than standard treatments. Participants received the drug locally at the surgery site, and pain levels were tracked for 24 h…

This study looked at 93 adults having bladder tumor surgery under spinal anesthesia. It compared two intravenous drugs—magnesium sulfate and dexmedetomidine—to see which better controlled pain after surgery. Magnesium sulfate led to lower pain scores, delayed the need for extra p…

This study tested a special nerve block against standard numbing medicine for pain during port catheter implantation. 66 adults took part. The goal was to see which method works better for pain control.

This study tested whether a natural enzyme mouthwash (ORAL7) helps wounds heal better after removing impacted lower wisdom teeth. 58 adults used either ORAL7 or a standard antiseptic mouthwash for one week after surgery. Researchers measured pain, mouth opening, and wound healing…

This study tested two methods to control pain after major abdominal surgery: a spinal injection of morphine and a newer nerve block technique. The goal was to see which provides better pain relief with fewer side effects. 56 adults participated, and the study measured how much ex…

This study tested a nerve block called the erector spinae plane block to see if it reduces pain after breast cancer surgery with implant reconstruction. 100 women scheduled for this surgery took part. The goal was to measure pain levels and recovery quality after the operation.

This study tested whether a combination of low-dose ketamine and lidocaine works better than fentanyl for pain after gynecologic surgery. 70 adults were randomly assigned to receive either the combo or fentanyl during surgery. Researchers measured pain scores, nausea, vomiting, a…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This study looked at ways to improve pain control after laparoscopic colorectal surgery. Researchers added either ketamine or a fentanyl skin patch to a standard nerve block (erector spinae plane block) to see if it would extend pain relief. The trial involved 120 adults and meas…

This study tested whether giving a numbing injection around the eye before retinal surgery could lower pain, nausea, and a reflex that slows the heart during the operation. 184 adults having vitreoretinal surgery took part. Researchers compared three different numbing medicines t…

This study tested two types of ultrasound-guided nerve blocks to control pain after open hysterectomy. 42 adults received either a transversus abdominis plane (TAP) block or an ilioinguinal-iliohypogastric (IIH) block. The goal was to see which block delayed the need for extra pa…

This study looked at two types of nerve blocks (SAP and PECS) to control pain after coronary artery bypass surgery. 243 adults having open heart surgery were randomly assigned to receive one of these blocks or standard pain medicine. The main goal was to see if the blocks helped …

This study tested whether a numbing injection (nerve block) given before thyroid surgery could lower pain and reduce the need for strong painkillers. Forty adults having their thyroid removed under general anesthesia took part. Half received the nerve block plus standard care, th…

This study tested whether gargling with ketamine before tonsil surgery can reduce pain afterward in children. 420 kids aged 4-12 either gargled with ketamine or a placebo. The goal was to see if this simple step could lower pain scores and the need for extra painkillers.

This study looked at whether giving intravenous paracetamol (a common pain reliever) before a total abdominal hysterectomy could lower the amount of morphine needed after surgery. Forty women aged 30-50 took part. The goal was to see if this simple step could reduce pain and reli…

This study tested whether a nerve block (sphenopalatine ganglion block) could reduce pain after maxillofacial (face) surgery. 60 adults were split into two groups: one received numbing medicine via a gauze and injection in the nose, the other received salt water (placebo) the sam…

This study tested three simple distraction methods—virtual reality headset, a squishy squeeze toy, and poetry reading—to see if they could help control pain after total knee replacement surgery. 140 adults were split into four groups, with three trying one of the distractions and…

This study looked at two ways to help the socket heal after removing impacted wisdom teeth: using a patient's own platelet-rich fibrin (PRF) or an absorbable collagen sponge. Twenty-nine healthy adults with similar wisdom teeth on both sides of their jaw took part. The goal was t…

This study tested two different methods (paracoracoid vs. costoclavicular) for placing tiny catheters near nerves to deliver pain medicine after hand surgery. 140 adults having outpatient hand surgery took part. The goal was to see which approach provides better numbness and pain…

This study tested whether a nerve block called the serratus anterior plane (SAP) block can reduce pain after heart surgery. 50 adults having heart surgery through a chest incision were randomly assigned to receive either a numbing medicine or a placebo through small tubes placed …

This study tested two different ways to numb the arm and shoulder during shoulder surgery to see which provides better pain relief and less impact on breathing. Thirty adults having shoulder arthroscopy received either a combination of two nerve blocks or a single block. Research…

This study tested three different pain-relief drugs (HTX-011, HTX-002, HTX-009) in 463 adults after open hernia surgery. Participants rated their pain over 24 hours to see how well each drug worked. The goal was to find a safe and effective way to manage pain after this common su…

This study compared two types of nerve blocks (ESPB and Rhomboid) to see which one works better for pain and reduces the need for strong painkillers after lung surgery. 76 adults having lung surgery took part. The goal was to find a better way to manage pain after the operation.

This study looked at whether giving a low dose of magnesium sulfate during lower back surgery can help reduce pain afterward. Sixty adults having lumbar spine surgery received either magnesium or a placebo. The goal was to see if magnesium could lower pain scores and the need for…

This study tested a pain-relief method called TENS-WAA, which uses mild electrical pulses on the skin based on acupuncture points, to see if it can ease pain after lung cancer surgery. 156 adults who had keyhole lung surgery received either the real treatment or a fake device. Th…

This study tested a new type of nerve block, called RISS, to see if it helps control pain after video-assisted chest surgery. 90 adults were randomly assigned to receive either the RISS block plus general anesthesia or general anesthesia alone. The goal was to see if the block re…

This study looked at 108 adults who needed a root canal on a back tooth. After standard cleaning, half got a final rinse with a traditional needle and half with an ultrasonic device. The goal was to see which method led to less pain after the procedure. Results will help dentists…

This study looked at whether listening to relaxing classical music could help new mothers feel less pain and anxiety after a cesarean delivery. 110 women who had just had their first baby by C-section took part. Starting 24 hours after birth, one group listened to music for 15 mi…

This study looked at 154 men having robot-assisted prostate removal. Researchers compared giving a combination of acetaminophen and ibuprofen either before surgery started or right after. The goal was to see if earlier dosing could lower the amount of strong opioid painkillers ne…

This study tested whether adding ketamine to general anesthesia helps reduce the need for morphine and lowers pain after breast cancer surgery. About 230 adults having mastectomy or lumpectomy took part. The goal was to see if ketamine could make recovery less painful and reduce …

This study looked at two types of nerve blocks—fascia iliaca block and femoral nerve block—to see which one works better for pain control in people having hip fracture surgery. 80 adults were randomly assigned to receive one of the two blocks before spinal anesthesia. The main go…

This study tested whether an ultrasound-guided nerve block (external oblique intercostal plane block) could reduce pain after kidney surgery. 25 adults were randomly assigned to receive either the nerve block or standard morphine. The goal was to see how long pain relief lasted a…

This study tested a new type of nerve block, called M-TAPA, to see how well it controls pain after a laparoscopic hysterectomy. Fifty women having the surgery received the block, and their pain was measured over 24 hours. The goal was to find a better way to manage pain after thi…

This study tested a long-acting painkiller called dinalbuphine sebacate in 634 adults having surgery. The goal was to see if better pain control could reduce complications like pneumonia and infections, and help patients heal faster. Researchers measured pain levels and painkille…

This study tested whether thread embedding acupuncture (placing a tiny thread under the skin at a specific back point) can reduce pain and improve quality of life after laparoscopic kidney donation surgery. 32 healthy kidney donors took part. Half received the real acupuncture pl…

This study tested two medicines, dexmedetomidine and lidocaine, given through an IV during mastectomy surgery to see which one controls pain better after the operation. Forty women having a modified radical mastectomy took part. The main goal was to see how long it took before th…

This study compared two ways of doing kidney stone surgery (PCNL). In the standard method, a tube is left in the kidney to drain urine, which can cause pain. In the tubeless method, no tube is placed. Researchers measured pain and painkiller use in 60 adults after surgery. The go…

This study looked at 40 infants under 1 year old having kidney surgery. They received a pain block with either bupivacaine alone or bupivacaine plus ketamine. The goal was to see if adding ketamine reduces pain and the need for extra pain medicine after surgery.

This study tested whether putting ice packs on the belly after a planned C-section could lower pain and the need for strong painkillers like opioids. Eighty women who had a C-section under spinal anesthesia took part. Half got standard pain care plus ice packs, and the other half…

This study looked at 200 adults having day surgery with general anesthesia to see if giving pain medication prescriptions before surgery (during the anesthesia check-up) reduces pain at home compared to giving the prescription after surgery. The main goal was to see how many peop…

This study tested whether doing progressive relaxation exercises after emergency general surgery could help with pain, anxiety, and vital signs like heart rate and breathing. Seventy adults were randomly assigned to either do these exercises at specific times after surgery or rec…

This study tested a new long-acting painkiller called HTX-011 in 418 adults having hernia surgery. The goal was to see if it reduces pain and the need for opioid pain pills after the operation. Participants received either the study drug, a standard painkiller, or a placebo to co…

This study looked at 84 women having a diagnostic hysteroscopy, a procedure to look inside the uterus. Researchers compared spinal anesthesia (numbing the lower body) with general anesthesia (being fully asleep) to see which led to less pain and higher satisfaction. The goal was …

This study tested three ways to manage pain during inguinal hernia repair: local anesthetic injection, quadratus lumborum block (QLB), and transversus abdominis plane (TAP) block. 90 adults having surgery under general anesthesia took part. Researchers measured recovery quality a…

This study tested three different doses of spinal morphine (50, 150, or 250 micrograms) to see which provides the longest pain relief after a C-section. 72 healthy women participated, and researchers measured how long until they needed extra pain medication. The goal is to improv…

This study compared two types of nerve blocks (ESP and RIB) to see which one provides better pain relief after breast surgery. 84 patients received one of the blocks, and researchers measured how much morphine they needed and their pain scores. The goal was to find a more effecti…

This study looked at whether giving children a drug called dexmedetomidine during tonsillectomy and adenoidectomy surgery can prevent restlessness and reduce pain afterward. 85 children aged 2-10 years took part. Researchers measured pain and anxiety levels after the operation to…

This study looked at whether using absorbable tacks to fix mesh in laparoscopic hernia repair causes more pain than leaving the mesh unfixed. Sixty adults with a single inguinal hernia were randomly assigned to one of the two methods. Researchers measured pain, quality of life, a…

This study tested a new pain-relief drug called HTX 011 in 412 adults having bunion surgery. The drug was given as a shot into the surgical site to manage pain and reduce the need for opioid painkillers. Results showed it worked better than a placebo and a standard painkiller, he…

This study tested whether injecting a long-lasting numbing medicine (bupivacaine) into surgical sites just before waking up from anesthesia could reduce pain and the need for strong painkillers after jaw surgery. 102 adults having jaw surgery took part. Researchers measured pain …

This study tested two ways to manage pain after heart surgery: one using a single nerve block near the breastbone, and another adding a second block near the ribs. 72 adults having planned heart surgery took part. The goal was to see if the combined block reduced pain and helped …

This study tested if a single session of light therapy, applied to the cheek right after removing an impacted wisdom tooth, could reduce pain, swelling, and jaw stiffness. 70 healthy adults took part. The light therapy helped lower pain in the first few days but did not reduce sw…

This study tested a new pain medicine called HTX 011 in 63 adults having hernia surgery. The goal was to see if it could help control pain and reduce the need for strong opioid painkillers. Researchers measured how many people needed no opioids after surgery and how much pain the…

This study tested whether adding a special nerve block (called PENG block) to standard pain injections could better control pain after hip replacement surgery. 64 adults scheduled for hip replacement took part. The goal was to see if the nerve block reduces the need for morphine …

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were followed for 90 days to track serious problems like heart attack, stroke, bleeding, or kidney failure. The goal was to help doctors decide if ibuprof…

This study tested two types of nerve blocks to control pain after total knee replacement. 62 patients received either a new para-sartorial block or a standard femoral-sciatic block. The goal was to see which provides better pain relief with less muscle weakness. Results will help…

This study tested whether putting lignocaine (a numbing medicine) inside the abdomen during gynecologic open surgery can reduce pain afterward. 112 women having surgery like hysterectomy or cystectomy took part. The goal was to see if this approach lowers pain scores and the need…

This study tested a new medicine called HTX-034 to see if it can control pain after bunion surgery better than the standard local anesthetic. 78 adults having bunion surgery received either HTX-034 or the standard treatment. The goal was to measure pain levels and safety over the…

This study compared two types of nerve blocks (TAP and QLB) to see which one better controls pain and reduces the need for strong painkillers after laparoscopic gallbladder removal. 65 adults having this surgery received one of the two blocks. The goal was to find a safer way to …

This study tested whether avoiding opioids during weight-loss surgery can still control pain effectively. Sixty adults with severe obesity were randomly assigned to receive either opioid-free or standard opioid anesthesia. Researchers measured pain levels, need for extra pain med…

This study tested whether showing patients a short video about moving after hip replacement surgery could reduce their fear of movement and pain. 96 adults scheduled for hip replacement were split into two groups: one got the usual verbal instructions, and the other also watched …

This study looked at how much local anesthetic to use in a nerve block (called PENG block) to control pain after hip replacement surgery. 50 adults having hip surgery received different volumes of the block. The goal was to find the best dose to reduce pain, lower the need for pa…

This study looked at 60 women having planned C-sections to see whether a diclofenac shot in the muscle or a rectal suppository works better for pain relief. Both methods were given every 8 hours for the first day after surgery. The goal is to help doctors choose the most effectiv…

This study looked at whether adding a numbing injection into the wound and a steroid medication during a planned C-section could lower the number of women experiencing severe pain after surgery. The researchers compared pain scores before and after making this change in 100 women…

This study tested a single dose of an experimental painkiller called HTX-011 given directly into the surgical site during bunionectomy. 78 adults having foot surgery received the drug to see if it could control pain and reduce the need for opioid painkillers. The goal was to impr…

This study tested a nerve block (intertransverse process block) given before heart surgery to see if it reduces pain afterward. 76 adults having planned coronary artery bypass grafting took part. Half received the nerve block and half a placebo. The researchers measured pain scor…

This study tested a special stitching technique during C-sections to see if it reduces pain and helps women get out of bed sooner. 60 women having their first C-section took part. The new method aims to put less tension on the tissue, which may lead to less pain and faster recove…

This study tested whether placing a gel made from a patient's own blood (platelet-rich fibrin) into the tooth socket after wisdom tooth removal can reduce pain, swelling, and jaw stiffness. Thirty adults with two impacted wisdom teeth each had one socket treated with the gel and …

This study tested whether a single dose of S-ketamine, given during surgery, could lower the amount of morphine patients needed for pain in the first 24 hours after laparoscopic gynecologic surgery. 53 relatively healthy adults took part. The goal was to see if S-ketamine could i…

This study tested whether a short mindfulness lesson before inguinal hernia surgery helps adults feel less pain afterward. 68 people took part, and researchers measured their pain, fear of pain, and how much pain interfered with daily life. The goal was to see if this simple, dru…

This study tested whether using an EEG (brain-wave) monitor during general anesthesia could reduce confusion and pain after dental surgery in children. 92 kids aged 4-10 were split into two groups: one got standard anesthesia care, the other got extra EEG guidance. The goal was t…

This study tested whether using a combination of dexmedetomidine and lignocaine (opioid-free anesthesia) could control pain as well as standard fentanyl (opioid-based anesthesia) in 60 adults undergoing nasal surgeries like sinus surgery or septoplasty. The goal was to see if the…

This study tested whether a numbing injection (nerve block) given before thyroid surgery helps people feel better the day after. 160 adults having thyroid surgery were randomly assigned to get either the numbing medicine or a saltwater placebo. They filled out surveys about their…

This study looked at whether using a special laser (diode laser) after a common dental procedure called direct pulp capping can help reduce pain and tooth sensitivity. Fifty-six people with tooth decay that reached the nerve were treated. Half got standard care, and half got stan…

This study tested whether using different amounts of numbing medicine in a back muscle injection (erector spinae plane block) could reduce pain and the need for morphine after a hysterectomy. 80 women having the surgery took part. The goal was to find the best volume for safer, m…

This study tested two doses of morphine given during spinal anesthesia for planned C-sections to see which provides better pain relief with fewer side effects. 240 women were randomly assigned to receive either 75 or 100 micrograms of morphine. Researchers measured pain levels an…

This study tested a new pain-relieving medicine called HTX-011 in 285 people having knee replacement surgery. The medicine was injected into the surgical area to see if it could reduce pain and the need for strong opioid painkillers. The goal was to find a safer, more effective w…

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

This study looked at 114 boys aged 2 to 7 having urogenital surgery to see if being anxious before the operation leads to more pain or confusion after waking up. Researchers measured anxiety before surgery and then tracked pain, delirium, and recovery speed in the recovery room. …

This completed study followed 1000 children aged 1-17 in southern Sweden who had common surgeries like hernia repair or tonsillectomy. Researchers wanted to see how many children develop long-lasting pain after surgery and whether doctors follow recommended pain treatment guideli…

This study examined whether giving lidocaine, ketamine, and magnesium during lung surgery helps reduce pain and the need for morphine afterward. Researchers followed 118 adults who had lung surgery and recorded their pain levels and opioid use. The goal was to see if this drug co…

This study surveyed 77 people who had a free gingival graft—a gum surgery to improve gum health—at least one year earlier. Researchers asked about pain, complications, appearance, and whether they would do it again. The goal is to better understand patient experiences and satisfa…

This study looked at how psychological factors like self-esteem and personality traits influence pain after cosmetic breast surgery. Researchers followed 52 adults to see if these traits could help predict pain levels and recovery. The goal is to create more personalized pain man…

This study looked at 120 adults having shoulder surgery. Researchers wanted to see if a tingling or electric shock feeling (called paresthesia) during a nerve block injection leads to nerve symptoms like numbness or weakness after the block wears off. They tracked what happened d…

This study tracked 582 children aged 6 to 18 who had surgery to see how many still had pain 3 months later. Researchers used a pain questionnaire to measure pain levels and identify risk factors. The goal was to better understand chronic post-operative pain in kids, not to test a…

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat (ENT) procedures. Researchers compared those who received opioid pain medication to those who received non-opioid alternatives. 160 adults participated, and the main go…

This completed study looked at 200 patients who had a sternotomy (chest bone cut open during heart surgery) to find out how many develop chronic pain three months later. Researchers asked about pain levels, sensations like burning or numbness, and how pain affected daily life. Th…

This study looked at 489 patients who had Achilles tendon surgery to find out what factors lead to moderate-to-severe pain in the first 24 hours. Researchers created a prediction tool (nomogram) based on these risk factors. The goal is to help doctors identify high-risk patients …

This study looked at how patients view the routine pain checks they receive after planned surgery. Researchers surveyed and interviewed 312 adults to understand whether these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain.…

This study followed 294 knee replacement patients to see how often they experienced sudden, severe pain after their nerve block wore off. Researchers tracked pain levels, sleep quality, and patient satisfaction. The goal was to better understand this 'rebound pain' and improve pa…

This study looked at how well standard pain treatments work for children after surgery. Researchers watched 219 kids aged 0-18 during their first hour after surgery and used special pain scales to measure their pain. The goal was to see if current methods are working well, not to…

This study looked at 120 women having mastectomy for breast cancer to see if the gender of their anesthesiologist affected their pain and need for painkillers after surgery. Researchers compared pain scores and medication use between patients treated by male versus female anesthe…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study looked at whether parents' confidence in letting their child be independent affects how much pain children feel after minor surgery. About 150 children aged 3 to 18 and their parents took part at a hospital in Turkey. Parents filled out questionnaires, and children's p…

This study looked at 72 adults with infected tooth roots to see if the type of filler used during root canal treatment changes how much pain they feel and how well the bone heals. Patients got one of three common fillers, and their pain was checked right after, at 24 hours, and a…

This study looked at how ketorolac, a non-steroidal anti-inflammatory drug (NSAID) used for pain after cesarean delivery, affects platelet function and blood clotting. Researchers measured clotting in 40 women undergoing scheduled C-sections using special blood tests. The goal wa…