POSTOPERATIVE PAIN

This study tested whether using a mesh patch to reinforce the abdominal wall during stoma reversal surgery reduces the chance of developing a hernia at the surgical site. Sixty-two patients who had a temporary stoma were randomly assigned to receive either mesh reinforcement or s…

This study tested whether avoiding opioids during weight-loss surgery can reduce pain, nausea, and the need for extra painkillers afterward. Sixty adults with severe obesity were randomly assigned to receive either opioid-free or standard opioid anesthesia. The goal is to see if …

This study tested three ways to manage pain before groin hernia surgery: numbing the area with local anesthetic, a quadratus lumborum block, or a transversus abdominis plane block. Researchers measured recovery quality and pain levels in 90 adults. The goal was to find which meth…

This study compared two methods for controlling pain after major abdominal surgery: injecting morphine into the spinal fluid (intrathecal morphine) versus a newer nerve block technique (M-TAPA) that numbs the abdominal wall. 56 adults participated. The goal was to see which metho…

This study looked at whether using a special electronic device during a second root canal treatment can lower pain afterward. 144 adults with infected teeth were treated with different settings on the device. Pain was checked over a week. The goal was to see if the device's modes…

This study looked at whether giving a common painkiller (paracetamol) through an IV before a total abdominal hysterectomy could lower the amount of morphine needed after surgery. Forty women aged 30-50 took part. The goal was to see if this simple step could reduce pain and relia…

This study tested whether using different amounts of numbing medicine in a back muscle injection (erector spinae plane block) could reduce pain and the need for morphine after a hysterectomy. 80 adults having the surgery took part. The goal was to find the best volume for better …

This study tested a single dose of an experimental drug called HTX-011, given directly into the surgical site during bunionectomy, to see if it could control pain and reduce the need for opioid painkillers. 78 adults having foot surgery took part. The goal was to find a better wa…

This study looked at 93 adults having bladder tumor surgery under spinal anesthesia. They received either magnesium sulfate, dexmedetomidine, or a placebo during the operation. Magnesium sulfate worked best, lowering pain scores, delaying the need for extra painkillers, and reduc…

This study tested whether the position a patient is placed in—lying on their side, on their stomach, or sitting up—affects how well a nerve block (erector spinae plane block) controls pain after gallbladder removal. 120 adults having planned laparoscopic gallbladder surgery took …

This study compared two types of nerve blocks (ESPB and Rhomboid block) to see which one works better for pain after lung surgery. 76 adults having lung surgery with a small camera (VATS) were randomly assigned to receive one of the blocks. The researchers measured pain levels, h…

This study tested whether giving ibuprofen before hernia surgery helps older adults avoid short-term confusion and memory problems. 76 men aged 65-84 received either ibuprofen or a placebo before surgery. Researchers measured thinking skills, pain levels, and recovery quality. Th…

This study tested whether a special type of acupuncture, called thread embedding acupuncture, can reduce pain and improve quality of life for people donating a kidney through laparoscopic surgery. 32 healthy kidney donors were randomly assigned to receive either real acupuncture …

This study tested two different nerve blocks—the erector spinae block and the quadratus lumborum block—to see which one works better for pain after abdominal surgery. 100 adults having surgery for colorectal, prostate, kidney cancer, or gallbladder removal took part. The goal was…

This study looked at 118 adults having lung surgery to see if giving a mix of lidocaine, ketamine, and magnesium during the operation could lower pain and the need for morphine afterward. Researchers measured pain levels and morphine use in the first 24 hours, as well as complica…

This study tested whether giving the numbing drug lidocaine through a vein during and after liver surgery can lower pain and reduce the need for strong opioid painkillers. 124 adults having minor liver surgery were randomly assigned to receive either lidocaine or a placebo (salt …

This study looked at whether a special nerve block (erector spinae plane block) can help reduce pain after lower back surgery. 102 adults were randomly assigned to receive either the nerve block or standard pain treatment. The goal was to see if the block leads to less pain, less…

This study looked at whether letting children play with sand before a tonsillectomy can lower their anxiety and pain. 68 kids aged 7-10 were split into two groups: one played with sand, the other got standard care. Researchers measured anxiety before surgery and pain after. The g…

This study tested whether doing progressive relaxation exercises after emergency general surgery can help with pain, anxiety, and vital signs like heart rate and breathing. Seventy adults were split into two groups: one did relaxation exercises at 6 hours, 1 day, and 2 days after…

This study tested if using sound waves to activate a cleaning solution during root canals on baby molars reduces children's pain afterward. Thirty children aged 5-8 with infected teeth took part. Researchers compared pain reports from a standard face scale with an AI app that rea…

This study tested whether a specific ultrasound-guided nerve block (external oblique intercostal plane block) could provide better pain relief after kidney surgery compared to standard morphine. Twenty-five adults undergoing subcostal nephrectomy were randomly assigned to receive…

This study looked at whether using an EEG (brain wave monitor) during general anesthesia can reduce confusion and pain after dental surgery in children. 92 kids aged 4-10 were split into two groups: one with standard monitoring and one with added EEG guidance. The goal was to see…

This study tested a new long-acting painkiller called HTX-011 in 418 adults having hernia surgery. The goal was to see if it could control pain and reduce the need for opioid painkillers after the operation. Participants received either HTX-011, a standard painkiller, or a placeb…

This study tested whether giving two pain medications—duloxetine and pregabalin—together before and after liposuction surgery could better control pain and reduce the need for stronger opioids. 90 adults aged 18 to 40 with a BMI up to 50 took part. The goal was to see if this com…

This study tested whether putting the numbing medicine lignocaine into the abdomen during open gynecologic surgery (like hysterectomy) reduces pain and the need for morphine afterward. 112 women took part. The goal was to see if this approach provides better pain control with few…

This study tested whether a mix of low-dose ketamine and lidocaine works better than fentanyl for pain after gynecologic surgery. 70 adults having elective surgery under general anesthesia took part. The goal was to see if the combo reduces pain and side effects like nausea, help…

This study looked at whether a special nerve block called PENG can help people who have partial hip replacement surgery feel less pain and need fewer painkillers. 48 adults having hip surgery were split into two groups: one got the nerve block plus standard care, the other got st…

This study looked at 84 women undergoing a diagnostic hysteroscopy, a common procedure to examine the uterus. Researchers compared spinal anesthesia with general anesthesia to see which one caused less pain after the procedure and led to higher patient satisfaction. The goal was …

This study tested whether injecting a long-acting numbing medicine (bupivacaine) into surgical sites just before patients woke up from anesthesia could lower pain and the need for strong painkillers after jaw surgery. 102 adults having jaw surgery were randomly assigned to receiv…

This study looked at whether giving a single high dose of vitamin C through a vein, along with nerve blocks, could help reduce pain and soreness after total knee replacement surgery. 73 adults aged 50 to 80 took part. The goal was to see if this combination improves early recover…

This study looked at whether showing patients a short educational video before hip replacement surgery could reduce their fear of moving after the operation. 96 adults scheduled for hip replacement were split into two groups: one got the usual verbal instructions plus a video, th…

This study tested whether a short mindfulness lesson before inguinal hernia surgery helps adults feel less pain afterward. 68 participants had their pain, fear of pain, and how much pain interfered with daily life measured before and after surgery. The goal was to see if mindfuln…

This study tested a new pain medicine called HTX 011 in 63 adults having hernia surgery. The goal was to see if it could help control pain and reduce the need for strong opioid painkillers. Participants received the drug during surgery, and researchers tracked how many needed no …

This study tested whether giving a single dose of S-ketamine during surgery could lower the amount of morphine patients need for pain in the first 24 hours after laparoscopic gynecologic surgery. Fifty-three relatively healthy adults took part. The goal was to see if S-ketamine c…

This study looked at 29 people who needed both lower wisdom teeth removed. It compared two materials placed in the empty tooth socket to see which helped healing better: a natural blood product called PRF or a collagen sponge. The goal was to reduce pain, swelling, and improve bo…

This study tested whether a calcium-phosphate desensitizer applied under a filling can reduce tooth sensitivity after the procedure. Fifty adults with cavities received either the desensitizer or no treatment, and rated their pain over 6 weeks. The goal was to see if the gel make…

This study tested whether adding a second nerve block (rectus sheath block) to a standard one (pectointercostal fascial plane block) could better control pain after heart surgery. 62 adults having planned heart surgery through a chest incision were randomly assigned to receive ei…

This study tested a special type of electrical nerve stimulation (TENS) based on wrist-ankle acupuncture points to see if it could reduce pain after lung surgery. 156 adults who had a lung lobe removed for cancer were randomly assigned to receive either the real TENS or a sham (f…

This study tested two different nerve block techniques to manage pain after shoulder arthroscopy. Thirty adults having shoulder surgery received either a combination of two blocks or a single block. Researchers measured pain levels and checked for temporary breathing muscle paral…

This study tested whether adding a numbing injection (wound infiltration and nerve block) plus an anti-inflammatory drug (dexamethasone) during a planned C-section could lower severe pain after surgery. About 100 women who had planned C-sections took part. The goal was to see if …

This study tested whether adding ketamine to general anesthesia could reduce the need for morphine and lessen pain after breast cancer surgery. About 230 adults having a mastectomy or lumpectomy took part. The goal was to see if ketamine helps control post-operative pain and lowe…

This study looked at whether a short counseling session before surgery could help people donating a kidney feel less anxious, have more stable vital signs during the operation, and experience less pain afterward. Researchers studied 123 adult kidney donors. The goal was to see if…

This study tested a new long-acting painkiller called HTX 011 in 412 adults having bunion surgery. The drug was given as a single shot into the surgical site. The goal was to see if it reduces pain and the need for opioid pain pills for three days after surgery, compared to a pla…

This study looked at whether applying ice packs to surgical cuts every 4 hours for 3 days helps adults recover after chest, belly, or groin surgery. 196 patients took part, and the main goal was to see if a larger study is possible. The researchers measured pain, recovery quality…

This study tested three experimental pain medicines (HTX-011, HTX-002, HTX-009) given locally during bunionectomy to control pain after surgery. 430 adults took part. The main goal was to measure how well they reduced pain over the first 24 hours. This is a phase 2 trial, meaning…

This study looked at 200 adults having day surgery with general anesthesia. It compared giving pain medication prescriptions before surgery versus after surgery. The goal was to see if getting the prescription earlier reduces moderate-to-severe pain at home within the first 24 ho…

This study tested whether a new type of nerve block (RISS) can reduce pain and the need for strong painkillers after chest surgery. 90 adults having chest surgery were randomly assigned to get the nerve block plus standard anesthesia or standard anesthesia alone. The researchers …

This study tested whether a nerve block in the cheek can reduce pain and the need for strong painkillers in children after tonsil and adenoid removal. About 114 children aged 6 months to 18 years took part. Researchers added a medicine called dexmedetomidine to the block to see i…

This study looked at whether applying ice packs after hemorrhoid surgery can reduce pain and the need for strong painkillers. Researchers compared 429 patients who either used ice packs or received standard care. The goal was to see if this simple, low-cost method could improve r…

This study tested whether a single session of light therapy (photobiomodulation) applied to the cheek right after wisdom tooth removal could reduce pain, swelling, and jaw stiffness. 70 healthy adults participated. The results showed that the light therapy helped lower pain and i…

This study looked at how often people have long-term pain 3 months after a sternotomy (a cut through the breastbone for heart or lung surgery). Researchers followed 200 adults and checked their pain levels and quality of life. The goal was to find out how common this chronic pain…

This study looked at 120 women having mastectomy for breast cancer to see if the gender of their anesthesiologist affected their pain and how much pain medicine they needed. Researchers also checked if having a male or female anesthesiologist changed the risk of complications. Th…

This study looked at how psychological factors like self-esteem and personality traits influence pain after cosmetic breast surgery. Researchers followed 52 adults to see if these factors could help predict who might need more pain relief. The goal is to create personalized pain …

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat surgery. Researchers compared those who received opioid painkillers to those who received non-opioid options. The goal was to see if non-opioid medicines could provide …

This study followed 294 knee replacement patients to see how often they experience sudden, severe pain after their nerve block wears off. Researchers tracked pain levels, sleep quality, and satisfaction with pain control. The goal is to help doctors better manage pain after surge…

This study followed 1,000 children aged 1-17 in southern Sweden who had common surgeries like hernia repair or tonsil removal. The goal was to see how many develop long-lasting pain and whether doctors follow European pain treatment guidelines. By identifying factors that lead to…

This study watched 114 children aged 2 to 7 years having urogenital surgery to see if being more anxious before the operation leads to more pain and confusion after waking up. Researchers measured anxiety right before anesthesia and then tracked pain, delirium, and recovery in th…

This study compared two ways to block the suprascapular nerve (a nerve in the shoulder) to control pain after arthroscopic shoulder surgery. Sixty adults having shoulder surgery received either an anterior (front) or posterior (back) nerve block. Researchers measured pain levels …