Knee surgery pain relief: does IV acetaminophen beat pills?
NCT ID NCT02216682
First seen Jun 20, 2026 · Last updated Jun 20, 2026
Summary
This study tested whether giving acetaminophen through an IV works better than taking it by mouth for pain after total knee replacement. 174 adults having knee surgery with spinal anesthesia were included. Researchers measured pain scores, how much opioid painkiller was needed, and time to recovery. The goal was to see if the IV form provides better pain control and reduces opioid use.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
acetaminophen
What this could lead to
If IV acetaminophen works better, it could reduce the need for stronger painkillers like opioids after surgery.
What could go wrong
This is a small, completed study. The difference between IV and oral forms may be small, and results may not apply to other surgeries or patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.