Vitamin c shot may boost pain relief after knee surgery
NCT ID NCT05514197
First seen Nov 19, 2025 · Last updated Jun 23, 2026 · Updated 32 times
Summary
This study looked at whether giving a single high dose of vitamin C along with nerve blocks before knee replacement surgery could reduce pain and help patients recover faster. 73 adults aged 50 to 80 took part. Half received vitamin C through an IV, and the other half got a placebo. Researchers measured pain levels, soreness, and how much morphine patients needed after surgery.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Chi Mei Medical Center
Tainan, Tainan City, 701, Taiwan
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vitamin C (ascorbic acid)
What this could lead to
If it works, this could offer a simple, low-cost way to reduce pain and speed up recovery after knee replacement surgery.
What could go wrong
This was a small, single-center study with only 73 participants. The results may not apply to everyone, and high-dose vitamin C can cause side effects like nausea or kidney stones in some people.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.